Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 324561..325327 Replicon chromosome
Accession NZ_CP024868
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag VCA1552_RS15755 Protein ID WP_000982260.1
Coordinates 324561..325058 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag VCA1552_RS15760 Protein ID WP_000246253.1
Coordinates 325055..325327 (-) Length 91 a.a.

Genomic Context

VCA1552_RS15695VCA1552_RS15700VCA1552_RS15720VCA1552_RS15725VCA1552_RS15730VCA1552_RS15745VCA1552_RS15750VCA1552_RS15765VCA1552_RS15770VCA1552_RS15780VCA1552_RS15800VCA1552_RS15805VCA1552_RS15810VCA1552_RS15815VCA1552_RS15820VCA1552_RS15825VCA1552_RS15830VCA1552_RS15710VCA1552_RS15715VCA1552_RS15755VCA1552_RS15760VCA1552_RS15785VCA1552_RS15790
Location: 320003..320707 (705 bp)
Type: Others
Protein ID: WP_000087610.1
Location: 320865..321203 (339 bp)
Type: Others
Protein ID: WP_000713853.1
Location: 322179..322565 (387 bp)
Type: Others
Protein ID: WP_001015867.1
Location: 322622..322735 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 322684..322965 (282 bp)
Type: Others
Protein ID: WP_001894429.1
Location: 323223..323759 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 323896..324411 (516 bp)
Type: Others
Protein ID: WP_001201509.1
Location: 325720..325845 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 325861..325899 (39 bp)
Type: Others
Protein ID: WP_106019118.1
Location: 326095..326541 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 327515..327793 (279 bp)
Type: Others
Protein ID: WP_001921601.1
Location: 328045..328251 (207 bp)
Type: Others
Protein ID: Protein_290
Location: 328451..328552 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 328542..328928 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 329123..329374 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 329347..329496 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 329588..329830 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 321357..321674 (318 bp)
Type: Others
Protein ID: WP_001180243.1
Location: 321693..321935 (243 bp)
Type: Others
Protein ID: WP_000557292.1
Location: 324561..325058 (498 bp)
Type: Toxin
Protein ID: WP_000982260.1
Location: 325055..325327 (273 bp)
Type: Antitoxin
Protein ID: WP_000246253.1
Location: 326689..326958 (270 bp)
Type: Others
Protein ID: WP_000277238.1
Location: 326951..327229 (279 bp)
Type: Others
Protein ID: WP_001258569.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
VCA1552_RS15695320003..320707+705WP_000087610.1HNH endonuclease-
VCA1552_RS15700320865..321203+339WP_000713853.1hypothetical protein-
VCA1552_RS15710321357..321674-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxin-
VCA1552_RS15715321693..321935-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
VCA1552_RS15720322179..322565+387WP_001015867.1NUDIX hydrolase-
VCA1552_RS15725322622..322735+114WP_001900214.1hypothetical protein-
VCA1552_RS15730322684..322965+282WP_001894429.1DUF1289 domain-containing protein-
VCA1552_RS15745323223..323759+537WP_000469482.1GNAT family N-acetyltransferase-
VCA1552_RS15750323896..324411+516WP_001201509.1lipocalin family protein-
VCA1552_RS15755324561..325058-498WP_000982260.1GNAT family N-acetyltransferaseToxin
VCA1552_RS15760325055..325327-273WP_000246253.1DUF1778 domain-containing proteinAntitoxin
VCA1552_RS15765325720..325845+126WP_001900195.1DUF645 family protein-
VCA1552_RS15770325861..325899+39WP_106019118.1hypothetical protein-
VCA1552_RS15780326095..326541+447WP_000006157.1hypothetical protein-
VCA1552_RS15785326689..326958-270WP_000277238.1type II toxin-antitoxin system YafQ family toxin-
VCA1552_RS15790326951..327229-279WP_001258569.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
VCA1552_RS15800327515..327793+279WP_001921601.1DUF3709 domain-containing protein-
VCA1552_RS15805328045..328251+207Protein_290DUF3709 domain-containing protein-
VCA1552_RS15810328451..328552+102WP_001921603.1hypothetical protein-
VCA1552_RS15815328542..328928+387WP_000703163.1VOC family protein-
VCA1552_RS15820329123..329374+252WP_001890111.1TIGR03643 family protein-
VCA1552_RS15825329347..329496+150WP_071908333.1DUF3265 domain-containing protein-
VCA1552_RS15830329588..329830+243WP_000107461.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304717..433978129261
insideIntegron--309797..433602123805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T88988 WP_000982260.1 NZ_CP024868:c325058-324561 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T88988 NZ_CP024868:c325058-324561 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT88988 WP_000246253.1 NZ_CP024868:c325327-325055 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT88988 NZ_CP024868:c325327-325055 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0KGB1

Antitoxin

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Source
ID
Structure
PDB1Y9B
AlphaFold DBA0A0F2IC79

References