88988

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 324561..325327 Replicon chromosome
Accession NZ_CP024868
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag VCA1552_RS15755 Protein ID WP_000982260.1
Coordinates 324561..325058 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag VCA1552_RS15760 Protein ID WP_000246253.1
Coordinates 325055..325327 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VCA1552_RS15695 320003..320707 + 705 WP_000087610.1 HNH endonuclease -
VCA1552_RS15700 320865..321203 + 339 WP_000713853.1 hypothetical protein -
VCA1552_RS15710 321357..321674 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin -
VCA1552_RS15715 321693..321935 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
VCA1552_RS15720 322179..322565 + 387 WP_001015867.1 NUDIX hydrolase -
VCA1552_RS15725 322622..322735 + 114 WP_001900214.1 hypothetical protein -
VCA1552_RS15730 322684..322965 + 282 WP_001894429.1 DUF1289 domain-containing protein -
VCA1552_RS15745 323223..323759 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
VCA1552_RS15750 323896..324411 + 516 WP_001201509.1 lipocalin family protein -
VCA1552_RS15755 324561..325058 - 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
VCA1552_RS15760 325055..325327 - 273 WP_000246253.1 DUF1778 domain-containing protein Antitoxin
VCA1552_RS15765 325720..325845 + 126 WP_001900195.1 DUF645 family protein -
VCA1552_RS15770 325861..325899 + 39 WP_106019118.1 hypothetical protein -
VCA1552_RS15780 326095..326541 + 447 WP_000006157.1 hypothetical protein -
VCA1552_RS15785 326689..326958 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin -
VCA1552_RS15790 326951..327229 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
VCA1552_RS15800 327515..327793 + 279 WP_001921601.1 DUF3709 domain-containing protein -
VCA1552_RS15805 328045..328251 + 207 Protein_290 DUF3709 domain-containing protein -
VCA1552_RS15810 328451..328552 + 102 WP_001921603.1 hypothetical protein -
VCA1552_RS15815 328542..328928 + 387 WP_000703163.1 VOC family protein -
VCA1552_RS15820 329123..329374 + 252 WP_001890111.1 TIGR03643 family protein -
VCA1552_RS15825 329347..329496 + 150 WP_071908333.1 DUF3265 domain-containing protein -
VCA1552_RS15830 329588..329830 + 243 WP_000107461.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304717..433978 129261
inside Integron - - 309797..433602 123805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T88988 WP_000982260.1 NZ_CP024868:c325058-324561 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T88988 NZ_CP024868:c325058-324561 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT88988 WP_000246253.1 NZ_CP024868:c325327-325055 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT88988 NZ_CP024868:c325327-325055 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2IC79

References