95379

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 68239..68798 Replicon chromosome
Accession NZ_CP026648
Organism Vibrio cholerae O1 biovar El Tor strain HC1037

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag C4E16_RS14625 Protein ID WP_000578476.1
Coordinates 68239..68517 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag C4E16_RS14630 Protein ID WP_000381183.1
Coordinates 68514..68798 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4E16_RS14575 63317..63823 + 507 WP_000393074.1 hypothetical protein -
C4E16_RS14580 63980..64366 + 387 WP_000703163.1 VOC family protein -
C4E16_RS14585 64623..64826 + 204 WP_001911580.1 hypothetical protein -
C4E16_RS14590 65021..65272 + 252 WP_104855997.1 TIGR03643 family protein -
C4E16_RS14595 65245..65394 + 150 WP_071908333.1 DUF3265 domain-containing protein -
C4E16_RS14600 65541..65966 + 426 WP_000415750.1 hypothetical protein -
C4E16_RS14605 66172..66795 + 624 WP_000247070.1 DUF1349 domain-containing protein -
C4E16_RS14610 67008..67487 + 480 WP_000009888.1 lecithin retinol acyltransferase family protein -
C4E16_RS14620 67675..68088 + 414 WP_000049420.1 VOC family protein -
C4E16_RS14625 68239..68517 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
C4E16_RS14630 68514..68798 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
C4E16_RS14635 68993..69508 + 516 WP_001201520.1 lipocalin family protein -
C4E16_RS14640 69573..70169 + 597 WP_000255434.1 hypothetical protein -
C4E16_RS14650 70561..70743 + 183 WP_000923182.1 DUF645 family protein -
C4E16_RS14655 70943..71416 + 474 WP_001161076.1 GrpB family protein -
C4E16_RS14660 71431..71523 + 93 WP_014378730.1 DUF3265 domain-containing protein -
C4E16_RS14665 71565..72191 + 627 WP_000365424.1 LysE family translocator -
C4E16_RS14670 72314..73012 + 699 WP_001890502.1 hypothetical protein -
C4E16_RS14675 73022..73132 + 111 WP_079857360.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 31043..136234 105191
inside Integron - - 36123..135858 99735


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T95379 WP_000578476.1 NZ_CP026648:c68517-68239 [Vibrio cholerae O1 biovar El Tor]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T95379 NZ_CP026648:c68517-68239 [Vibrio cholerae O1 biovar El Tor]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT95379 WP_000381183.1 NZ_CP026648:c68798-68514 [Vibrio cholerae O1 biovar El Tor]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT95379 NZ_CP026648:c68798-68514 [Vibrio cholerae O1 biovar El Tor]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9K2M8

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References