Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 68239..68798 Replicon chromosome
Accession NZ_CP026648
Organism Vibrio cholerae O1 biovar El Tor strain HC1037

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag C4E16_RS14625 Protein ID WP_000578476.1
Coordinates 68239..68517 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag C4E16_RS14630 Protein ID WP_000381183.1
Coordinates 68514..68798 (-) Length 95 a.a.

Genomic Context

C4E16_RS14575C4E16_RS14580C4E16_RS14585C4E16_RS14590C4E16_RS14595C4E16_RS14600C4E16_RS14605C4E16_RS14610C4E16_RS14620C4E16_RS14635C4E16_RS14640C4E16_RS14650C4E16_RS14655C4E16_RS14660C4E16_RS14665C4E16_RS14670C4E16_RS14675C4E16_RS14625C4E16_RS14630
Location: 63317..63823 (507 bp)
Type: Others
Protein ID: WP_000393074.1
Location: 63980..64366 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 64623..64826 (204 bp)
Type: Others
Protein ID: WP_001911580.1
Location: 65021..65272 (252 bp)
Type: Others
Protein ID: WP_104855997.1
Location: 65245..65394 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 65541..65966 (426 bp)
Type: Others
Protein ID: WP_000415750.1
Location: 66172..66795 (624 bp)
Type: Others
Protein ID: WP_000247070.1
Location: 67008..67487 (480 bp)
Type: Others
Protein ID: WP_000009888.1
Location: 67675..68088 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 68993..69508 (516 bp)
Type: Others
Protein ID: WP_001201520.1
Location: 69573..70169 (597 bp)
Type: Others
Protein ID: WP_000255434.1
Location: 70561..70743 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 70943..71416 (474 bp)
Type: Others
Protein ID: WP_001161076.1
Location: 71431..71523 (93 bp)
Type: Others
Protein ID: WP_014378730.1
Location: 71565..72191 (627 bp)
Type: Others
Protein ID: WP_000365424.1
Location: 72314..73012 (699 bp)
Type: Others
Protein ID: WP_001890502.1
Location: 73022..73132 (111 bp)
Type: Others
Protein ID: WP_079857360.1
Location: 68239..68517 (279 bp)
Type: Toxin
Protein ID: WP_000578476.1
Location: 68514..68798 (285 bp)
Type: Antitoxin
Protein ID: WP_000381183.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
C4E16_RS1457563317..63823+507WP_000393074.1hypothetical protein-
C4E16_RS1458063980..64366+387WP_000703163.1VOC family protein-
C4E16_RS1458564623..64826+204WP_001911580.1hypothetical protein-
C4E16_RS1459065021..65272+252WP_104855997.1TIGR03643 family protein-
C4E16_RS1459565245..65394+150WP_071908333.1DUF3265 domain-containing protein-
C4E16_RS1460065541..65966+426WP_000415750.1hypothetical protein-
C4E16_RS1460566172..66795+624WP_000247070.1DUF1349 domain-containing protein-
C4E16_RS1461067008..67487+480WP_000009888.1lecithin retinol acyltransferase family protein-
C4E16_RS1462067675..68088+414WP_000049420.1VOC family protein-
C4E16_RS1462568239..68517-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
C4E16_RS1463068514..68798-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
C4E16_RS1463568993..69508+516WP_001201520.1lipocalin family protein-
C4E16_RS1464069573..70169+597WP_000255434.1hypothetical protein-
C4E16_RS1465070561..70743+183WP_000923182.1DUF645 family protein-
C4E16_RS1465570943..71416+474WP_001161076.1GrpB family protein-
C4E16_RS1466071431..71523+93WP_014378730.1DUF3265 domain-containing protein-
C4E16_RS1466571565..72191+627WP_000365424.1LysE family translocator-
C4E16_RS1467072314..73012+699WP_001890502.1hypothetical protein-
C4E16_RS1467573022..73132+111WP_079857360.1DUF3265 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-31043..136234105191
insideIntegron--36123..13585899735


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T95379 WP_000578476.1 NZ_CP026648:c68517-68239 [Vibrio cholerae O1 biovar El Tor]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T95379 NZ_CP026648:c68517-68239 [Vibrio cholerae O1 biovar El Tor]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT95379 WP_000381183.1 NZ_CP026648:c68798-68514 [Vibrio cholerae O1 biovar El Tor]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT95379 NZ_CP026648:c68798-68514 [Vibrio cholerae O1 biovar El Tor]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9K2M8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A067BL33

References