230649

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 918323..918863 Replicon chromosome
Accession NZ_CP090400
Organism Vibrio cholerae strain PanChol

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag LZM82_RS18050 Protein ID WP_000277238.1
Coordinates 918594..918863 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag LZM82_RS18045 Protein ID WP_001258569.1
Coordinates 918323..918601 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZM82_RS17990 (LZM82_17990) 913903..914370 - 468 WP_001289288.1 OsmC family protein -
LZM82_RS17995 (LZM82_17995) 914542..914673 - 132 WP_001883067.1 hypothetical protein -
LZM82_RS18000 (LZM82_18000) 915192..915470 - 279 WP_000280324.1 DUF3709 domain-containing protein -
LZM82_RS18005 (LZM82_18005) 915722..915964 - 243 WP_000107461.1 hypothetical protein -
LZM82_RS18010 (LZM82_18010) 916056..916205 - 150 WP_071908333.1 DUF3265 domain-containing protein -
LZM82_RS18015 (LZM82_18015) 916178..916429 - 252 WP_001890111.1 TIGR03643 family protein -
LZM82_RS18020 (LZM82_18020) 916624..917010 - 387 WP_000703163.1 VOC family protein -
LZM82_RS18025 (LZM82_18025) 917000..917101 - 102 WP_001921603.1 hypothetical protein -
LZM82_RS18030 (LZM82_18030) 917301..917399 - 99 WP_223225486.1 DUF3709 domain-containing protein -
LZM82_RS18035 (LZM82_18035) 917759..918037 - 279 WP_001921601.1 DUF3709 domain-containing protein -
LZM82_RS18040 (LZM82_18040) 918155..918272 - 118 Protein_876 DUF3265 domain-containing protein -
LZM82_RS18045 (LZM82_18045) 918323..918601 + 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LZM82_RS18050 (LZM82_18050) 918594..918863 + 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin Toxin
LZM82_RS18055 (LZM82_18055) 919050..920261 - 1212 WP_001122813.1 IS256 family transposase -
LZM82_RS18060 (LZM82_18060) 920324..920770 - 447 WP_000006157.1 hypothetical protein -
LZM82_RS18065 (LZM82_18065) 921020..921145 - 126 WP_001900195.1 DUF645 family protein -
LZM82_RS18070 (LZM82_18070) 921538..921810 + 273 WP_000246253.1 DUF1778 domain-containing protein -
LZM82_RS18075 (LZM82_18075) 921807..922304 + 498 WP_000982260.1 GNAT family N-acetyltransferase -
LZM82_RS18080 (LZM82_18080) 922321..922389 - 69 Protein_884 acetyltransferase -
LZM82_RS18085 (LZM82_18085) 922454..922915 - 462 WP_001903091.1 lipocalin family protein -
LZM82_RS18090 (LZM82_18090) 923106..923642 - 537 WP_000469482.1 GNAT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 835643..943910 108267
inside Integron - - 836019..937068 101049
- flank IS/Tn - - 919050..920261 1211


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T230649 WP_000277238.1 NZ_CP090400:918594-918863 [Vibrio cholerae]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T230649 NZ_CP125227:c75622-75233 [Acinetobacter pittii]
TTGATAAAAGAATTAAATTTTGAGCTGAAATATAGTCGTGTCTCGGTAGTATTTCAGCTTTTTGTTGGTTTGGGTTTAGC
AATTCTGCTTTATCAATTATTAACACCCATGTGGTGGCTATGCGCTGTCATTCTTCTATTTATTGGTTTTATTTTCTTTT
TAAAGCAAGTACAAATATCTCAAATTGAATATTTAGATCAAAAATTATGGTCGGTTGCATATTTCTCGGAAAAAGAAATT
TACCGTGCAGAAATTACTAAAATAATTGATTATCAGCTATTTGTAGTTATTTATTTTGAAGAGACTCCTACGAATATAGC
TATTGTTTGGTTCGATCAGCTTCCTATTCAGCAGTGGAAAAGATTAAAAGTTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT230649 WP_001258569.1 NZ_CP090400:918323-918601 [Vibrio cholerae]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp

>AT230649 NZ_CP125227:c75886-75629 [Acinetobacter pittii]
ATGTCTGACGAAATGACCTTGGAAGAACGTAAAGTAATTTATCGAGCACGCCGCGGCTTAAAAGAAATTGACGTCTATTT
TGACCCGTATGTAAAAAACTATTATTTAAAAGCTGATCCAGCAGAAAAAGCATTATTTGCAGAGTTAGTCGATCAAGAAG
ATCCGGATTTATTAGATTGGTTCATGGAAGTTTCTGAACCTCCACGTACTGAGTTACGTGAATTTATTTATAAACTAAAA
CAGTATGTACATGGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A151JGK8

Antitoxin

Source ID Structure
AlphaFold DB A0A151KTP9

References