Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 918323..918863 Replicon chromosome
Accession NZ_CP090400
Organism Vibrio cholerae strain PanChol

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag LZM82_RS18050 Protein ID WP_000277238.1
Coordinates 918594..918863 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag LZM82_RS18045 Protein ID WP_001258569.1
Coordinates 918323..918601 (+) Length 93 a.a.

Genomic Context

LZM82_RS18045LZM82_RS18050LZM82_RS18070LZM82_RS18075LZM82_RS17990LZM82_RS17995LZM82_RS18000LZM82_RS18005LZM82_RS18010LZM82_RS18015LZM82_RS18020LZM82_RS18025LZM82_RS18030LZM82_RS18035LZM82_RS18040LZM82_RS18055LZM82_RS18060LZM82_RS18065LZM82_RS18080LZM82_RS18085LZM82_RS18090
Location: 918323..918601 (279 bp)
Type: Antitoxin
Protein ID: WP_001258569.1
Location: 918594..918863 (270 bp)
Type: Toxin
Protein ID: WP_000277238.1
Location: 921538..921810 (273 bp)
Type: Others
Protein ID: WP_000246253.1
Location: 921807..922304 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 913903..914370 (468 bp)
Type: Others
Protein ID: WP_001289288.1
Location: 914542..914673 (132 bp)
Type: Others
Protein ID: WP_001883067.1
Location: 915192..915470 (279 bp)
Type: Others
Protein ID: WP_000280324.1
Location: 915722..915964 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 916056..916205 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 916178..916429 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 916624..917010 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 917000..917101 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 917301..917399 (99 bp)
Type: Others
Protein ID: WP_223225486.1
Location: 917759..918037 (279 bp)
Type: Others
Protein ID: WP_001921601.1
Location: 918155..918272 (118 bp)
Type: Others
Protein ID: Protein_876
Location: 919050..920261 (1212 bp)
Type: Others
Protein ID: WP_001122813.1
Location: 920324..920770 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 921020..921145 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 922321..922389 (69 bp)
Type: Others
Protein ID: Protein_884
Location: 922454..922915 (462 bp)
Type: Others
Protein ID: WP_001903091.1
Location: 923106..923642 (537 bp)
Type: Others
Protein ID: WP_000469482.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LZM82_RS17990 (LZM82_17990)913903..914370-468WP_001289288.1OsmC family protein-
LZM82_RS17995 (LZM82_17995)914542..914673-132WP_001883067.1hypothetical protein-
LZM82_RS18000 (LZM82_18000)915192..915470-279WP_000280324.1DUF3709 domain-containing protein-
LZM82_RS18005 (LZM82_18005)915722..915964-243WP_000107461.1hypothetical protein-
LZM82_RS18010 (LZM82_18010)916056..916205-150WP_071908333.1DUF3265 domain-containing protein-
LZM82_RS18015 (LZM82_18015)916178..916429-252WP_001890111.1TIGR03643 family protein-
LZM82_RS18020 (LZM82_18020)916624..917010-387WP_000703163.1VOC family protein-
LZM82_RS18025 (LZM82_18025)917000..917101-102WP_001921603.1hypothetical protein-
LZM82_RS18030 (LZM82_18030)917301..917399-99WP_223225486.1DUF3709 domain-containing protein-
LZM82_RS18035 (LZM82_18035)917759..918037-279WP_001921601.1DUF3709 domain-containing protein-
LZM82_RS18040 (LZM82_18040)918155..918272-118Protein_876DUF3265 domain-containing protein-
LZM82_RS18045 (LZM82_18045)918323..918601+279WP_001258569.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
LZM82_RS18050 (LZM82_18050)918594..918863+270WP_000277238.1type II toxin-antitoxin system YafQ family toxinToxin
LZM82_RS18055 (LZM82_18055)919050..920261-1212WP_001122813.1IS256 family transposase-
LZM82_RS18060 (LZM82_18060)920324..920770-447WP_000006157.1hypothetical protein-
LZM82_RS18065 (LZM82_18065)921020..921145-126WP_001900195.1DUF645 family protein-
LZM82_RS18070 (LZM82_18070)921538..921810+273WP_000246253.1DUF1778 domain-containing protein-
LZM82_RS18075 (LZM82_18075)921807..922304+498WP_000982260.1GNAT family N-acetyltransferase-
LZM82_RS18080 (LZM82_18080)922321..922389-69Protein_884acetyltransferase-
LZM82_RS18085 (LZM82_18085)922454..922915-462WP_001903091.1lipocalin family protein-
LZM82_RS18090 (LZM82_18090)923106..923642-537WP_000469482.1GNAT family protein-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-835643..943910108267
insideIntegron--836019..937068101049
-flankIS/Tn--919050..9202611211


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T230649 WP_000277238.1 NZ_CP090400:918594-918863 [Vibrio cholerae]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T230649 NZ_CP125227:c75622-75233 [Acinetobacter pittii]
TTGATAAAAGAATTAAATTTTGAGCTGAAATATAGTCGTGTCTCGGTAGTATTTCAGCTTTTTGTTGGTTTGGGTTTAGC
AATTCTGCTTTATCAATTATTAACACCCATGTGGTGGCTATGCGCTGTCATTCTTCTATTTATTGGTTTTATTTTCTTTT
TAAAGCAAGTACAAATATCTCAAATTGAATATTTAGATCAAAAATTATGGTCGGTTGCATATTTCTCGGAAAAAGAAATT
TACCGTGCAGAAATTACTAAAATAATTGATTATCAGCTATTTGTAGTTATTTATTTTGAAGAGACTCCTACGAATATAGC
TATTGTTTGGTTCGATCAGCTTCCTATTCAGCAGTGGAAAAGATTAAAAGTTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT230649 WP_001258569.1 NZ_CP090400:918323-918601 [Vibrio cholerae]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp

>AT230649 NZ_CP125227:c75886-75629 [Acinetobacter pittii]
ATGTCTGACGAAATGACCTTGGAAGAACGTAAAGTAATTTATCGAGCACGCCGCGGCTTAAAAGAAATTGACGTCTATTT
TGACCCGTATGTAAAAAACTATTATTTAAAAGCTGATCCAGCAGAAAAAGCATTATTTGCAGAGTTAGTCGATCAAGAAG
ATCCGGATTTATTAGATTGGTTCATGGAAGTTTCTGAACCTCCACGTACTGAGTTACGTGAATTTATTTATAAACTAAAA
CAGTATGTACATGGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A151JGK8

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A151KTP9

References