Detailed information of TA system TA058392

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /DUF1778(antitoxin)
• Location: 356759..357609
• Replicon: chromosome
• Accession: NZ_CP013318
• Organism: Vibrio cholerae strain NCTC5395

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q9KM94
• Locus tag: ASZ85_RS15835
• Protein ID: WP_000118351.1
• Coordinates: 357076..357609 (+)
• Length: 178 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: ASZ85_RS15830
• Protein ID: WP_001909340.1
• Coordinates: 356759..357079 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ASZ85_RS15790	352095..352577	+	483	WP_000422940.1	GNAT family N-acetyltransferase	-
ASZ85_RS15800	353385..353654	+	270	WP_001114075.1	DUF4160 domain-containing protein	-
ASZ85_RS15805	353648..354169	+	522	WP_000921692.1	DUF2442 domain-containing protein	-
ASZ85_RS20925	354226..354339	+	114	WP_001894981.1	hypothetical protein	-
ASZ85_RS15810	354308..355144	+	837	WP_000242986.1	hypothetical protein	-
ASZ85_RS15815	355309..355947	+	639	WP_000230118.1	HD domain-containing protein	-
ASZ85_RS20930	356037..356197	+	161	Protein_318	DUF3709 domain-containing protein	-
ASZ85_RS15820	356218..356439	+	222	WP_012705854.1	DUF3709 domain-containing protein	-
ASZ85_RS15830	356759..357079	+	321	WP_001909340.1	DUF1778 domain-containing protein	Antitoxin
ASZ85_RS15835	357076..357609	+	534	WP_000118351.1	GNAT family N-acetyltransferase	Toxin
ASZ85_RS15840	357847..358125	+	279	WP_000280324.1	DUF3709 domain-containing protein	-
ASZ85_RS15845	358526..358750	+	225	WP_001894423.1	DUF3709 domain-containing protein	-
ASZ85_RS15855	359488..359877	+	390	WP_000491263.1	VOC family protein	-
ASZ85_RS15860	360010..360525	+	516	WP_000090008.1	hypothetical protein	-
ASZ85_RS15865	360666..361103	+	438	WP_001202554.1	NUDIX pyrophosphatase	-
ASZ85_RS15870	361264..361611	+	348	WP_000933409.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	338285..496833	158548
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 Integron TA000164, TA000169, TA000166, TA000167, TA000179, TA000170, TA000171, TA000172, TA000173, TA000174, TA000175, TA000176, TA000177, TA000178, TA000168, TA000165, TA010030, TA010035 309750..435387 0.009	inside	Integron	-	-	343365..496457	153092

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (97-153)

Antitoxin

• Vibrio phage ICP1, Orf50 (22-98)

Sequences

Toxin

Protein

• Length: 178 a.a.
• Molecular weight: 20171.46 Da
• Isoelectric Point: 9.1432

>T58392 WP_000118351.1 NZ_CP013318:357076-357609 [Vibrio cholerae]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ

Nucleotide

• Length: 534 bp

>T58392 NZ_CP013318:357076-357609 [Vibrio cholerae]
GTGAGTTGGGGCAAAGAGTTTGTAGAACTTAGTAAATCAAAGCATGACCGCGACTCATTTGACTGTGGTGAGCAAGAGCT
AAACACATTTATCAAAACTCAAGCTGCAAAGCACATGCAAGCAGGTATTAGTCGAACAATGGTTTTACCTAGTGCTCACC
CACTGTTAAATCAAAAATTCGCTATTTGTGCCTTTTATAGTGTTGCACCGAGCTCAATCAGCCGAGAAACATTACCGGCA
CAATTAGCAAAGAAACTACCGAGGTATCCAATCCCTGTTTTTCTGTTGGCTCAGTTAGCTGTGCACAAAGAATTTCACGG
TTCTGGACTTGGAAAGGTCAGTCTAATCCGTGCGCTGAAGTACTTGTGGGAAGTGAATCATCACATGAGAGCATATGCAA
TAGTTGTGGATTGTCTGACAGATTCCGCTCAAGCGTTCTATACGAAGTTCGGCTTTGAAGTATTGTGCGAACATAATGAG
CGTATTCGTATGTTCTTACCGATGAAAACGGTAGAACAACTTTTTAATCAATAG

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 11759.53 Da
• Isoelectric Point: 4.9309

>AT58392 WP_001909340.1 NZ_CP013318:356759-357079 [Vibrio cholerae]
MAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFM
AACNKVKAPNQALLEAVKFTEKSGIK

Nucleotide

• Length: 321 bp

>AT58392 NZ_CP013318:356759-357079 [Vibrio cholerae]
TTGGCCTATAATCGCTCAACTGACGGAATGTATCCGTACGCAGGAGGGGTTATGGCAACGGCACGTTTAGATATCCGCCT
TGATGAAGAGATCAAGGCAAAAGCCGAAAAGGCATCGGCTTTACTTGGTTTAAAAAGTCTCACTGAATATGTGGTGAGAC
TTATGGACGAAGATGCGACTCATGTTATTGAGGAGCATGAAAGTATTATGGTTAAAGACAGTGTTTTTGACGAGTTTATG
GCTGCGTGTAATAAAGTAAAAGCACCGAATCAAGCTTTGCTTGAAGCTGTTAAATTTACAGAGAAGAGCGGTATCAAGTG
A

Structures

Toxin

• AlphaFold DB: Q9KM94