Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 116728..117361 Replicon chromosome
Accession NZ_CP007635
Organism Vibrio cholerae strain 2012EL-2176

Toxin (Protein)


Gene name higB Uniprot ID Q9KMA6
Locus tag EN18_RS14905 Protein ID WP_000843587.1
Coordinates 116728..117060 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EN18_RS14910 Protein ID WP_000071008.1
Coordinates 117047..117361 (+) Length 105 a.a.

Genomic Context

EN18_RS21390EN18_RS21210EN18_RS14880EN18_RS20690EN18_RS14885EN18_RS14890EN18_RS14895EN18_RS21575EN18_RS20695EN18_RS20710EN18_RS20715EN18_RS14905EN18_RS14910EN18_RS14915EN18_RS21395EN18_RS14930EN18_RS14935EN18_RS14940EN18_RS21220EN18_RS14945EN18_RS14950EN18_RS14955EN18_RS14925
Location: 112169..112372 (204 bp)
Type: Others
Protein ID: WP_001911745.1
Location: 112653..112826 (174 bp)
Type: Others
Protein ID: WP_001882305.1
Location: 113186..113455 (270 bp)
Type: Others
Protein ID: WP_001198131.1
Location: 113773..113944 (172 bp)
Type: Others
Protein ID: Protein_170
Location: 114153..114539 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 114741..114983 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 115154..115531 (378 bp)
Type: Others
Protein ID: WP_000411109.1
Location: 115588..115702 (115 bp)
Type: Others
Protein ID: Protein_174
Location: 115651..115932 (282 bp)
Type: Others
Protein ID: WP_001894453.1
Location: 116098..116211 (114 bp)
Type: Others
Protein ID: WP_001889158.1
Location: 116160..116387 (228 bp)
Type: Others
Protein ID: WP_073426587.1
Location: 116728..117060 (333 bp)
Type: Toxin
Protein ID: WP_000843587.1
Location: 117047..117361 (315 bp)
Type: Antitoxin
Protein ID: WP_000071008.1
Location: 117498..117932 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 118100..118255 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 119428..119734 (307 bp)
Type: Others
Protein ID: Protein_183
Location: 119871..120563 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 120563..120964 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 120934..121077 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 121152..121565 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 121779..122030 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 122020..122307 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 118380..119360 (981 bp)
Type: Others
Protein ID: WP_000019370.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EN18_RS21390112169..112372+204WP_001911745.1hypothetical protein-
EN18_RS21210112653..112826+174WP_001882305.1DUF3709 domain-containing protein-
EN18_RS14880113186..113455+270WP_001198131.1hypothetical protein-
EN18_RS20690113773..113944+172Protein_170DUF645 family protein-
EN18_RS14885114153..114539+387WP_000703163.1VOC family protein-
EN18_RS14890114741..114983+243WP_000107461.1hypothetical protein-
EN18_RS14895115154..115531+378WP_000411109.1hypothetical protein-
EN18_RS21575115588..115702+115Protein_174acetyltransferase-
EN18_RS20695115651..115932+282WP_001894453.1DUF1289 domain-containing protein-
EN18_RS20710116098..116211+114WP_001889158.1hypothetical protein-
EN18_RS20715116160..116387+228WP_073426587.1DUF1289 domain-containing protein-
EN18_RS14905116728..117060+333WP_000843587.1type II toxin-antitoxin system RelE/ParE family toxinToxin
EN18_RS14910117047..117361+315WP_000071008.1DNA-binding transcriptional regulatorAntitoxin
EN18_RS14915117498..117932+435WP_000256036.1GNAT family N-acetyltransferase-
EN18_RS21395118100..118255+156WP_000751734.1hypothetical protein-
EN18_RS14925118380..119360-981WP_000019370.1IS5-like element ISVch5 family transposase-
EN18_RS14930119428..119734+307Protein_183CatB-related O-acetyltransferase-
EN18_RS14935119871..120563+693WP_001047169.1GNAT family N-acetyltransferase-
EN18_RS14940120563..120964+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
EN18_RS21220120934..121077+144WP_071908341.1DUF3265 domain-containing protein-
EN18_RS14945121152..121565+414WP_000049417.1VOC family protein-
EN18_RS14950121779..122030+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
EN18_RS14955122020..122307+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-31037..137542106505
insideIntegron--36117..137166101049
flankIS/Tn--118380..119360980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 13005.95 Da        Isoelectric Point: 9.9244

>T46758 WP_000843587.1 NZ_CP007635:116728-117060 [Vibrio cholerae]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS

Download         Length: 333 bp

>T46758 NZ_CP007635:116728-117060 [Vibrio cholerae]
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAATATCTCAGTGATGAGGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAACCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTTGCGA
GTAAAGGCAAGGGAAAGCGTGGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGGCGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCTGACTTGAATGCAAATCAAAGGAAACAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11696.20 Da        Isoelectric Point: 6.7600

>AT46758 WP_000071008.1 NZ_CP007635:117047-117361 [Vibrio cholerae]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL

Download         Length: 315 bp

>AT46758 NZ_CP007635:117047-117361 [Vibrio cholerae]
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAGCAGCATTCAGAAGGTAAGCTTACTCT
GAAAACACATCATGTGAATGATGTGGGTGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTCAATA
TGTCCCGCGGAGTCTTCGCGCGGTTACTTCATACGTCTTCGCGCACATTAGAAAACTGGGAACAAGGTCGTAGTGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCCGAGCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB5JA9
PDB8A0X
PDB5MJE
PDB5JA8
PDB5JAA

Antitoxin

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Source
ID
Structure
No matching records found

References