58219

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 359410..360176 Replicon chromosome
Accession NZ_CP013302
Organism Vibrio cholerae strain C5

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag ASZ80_RS16040 Protein ID WP_000982260.1
Coordinates 359410..359907 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag ASZ80_RS16045 Protein ID WP_000246253.1
Coordinates 359904..360176 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ80_RS15990 354852..355556 + 705 WP_000087610.1 HNH endonuclease -
ASZ80_RS15995 355714..356052 + 339 WP_000713853.1 hypothetical protein -
ASZ80_RS16000 356206..356523 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin -
ASZ80_RS16005 356542..356784 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
ASZ80_RS16010 357028..357414 + 387 WP_001015867.1 NUDIX hydrolase -
ASZ80_RS16015 357471..357584 + 114 WP_001900214.1 hypothetical protein -
ASZ80_RS16020 357533..357814 + 282 WP_001894429.1 DUF1289 domain-containing protein -
ASZ80_RS16030 358072..358608 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
ASZ80_RS16035 358745..359260 + 516 WP_001201509.1 lipocalin family protein -
ASZ80_RS16040 359410..359907 - 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
ASZ80_RS16045 359904..360176 - 273 WP_000246253.1 DUF1778 domain-containing protein Antitoxin
ASZ80_RS20495 360569..360694 + 126 WP_001900195.1 DUF645 family protein -
ASZ80_RS20500 360710..360748 + 39 WP_106019118.1 hypothetical protein -
ASZ80_RS16055 360944..361390 + 447 WP_000006157.1 hypothetical protein -
ASZ80_RS16060 361538..361807 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin -
ASZ80_RS16065 361800..362078 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
ASZ80_RS16070 362364..362642 + 279 WP_001921601.1 DUF3709 domain-containing protein -
ASZ80_RS20515 362894..363100 + 207 Protein_348 DUF3709 domain-containing protein -
ASZ80_RS20520 363300..363401 + 102 WP_001921603.1 hypothetical protein -
ASZ80_RS16075 363391..363777 + 387 WP_000703163.1 VOC family protein -
ASZ80_RS16080 363972..364223 + 252 WP_001890111.1 TIGR03643 family protein -
ASZ80_RS16085 364196..364345 + 150 WP_071908333.1 DUF3265 domain-containing protein -
ASZ80_RS16090 364437..364679 + 243 WP_000107461.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304694..469286 164592
inside Integron - - 309774..468910 159136


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T58219 WP_000982260.1 NZ_CP013302:c359907-359410 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T58219 NZ_CP013302:c359907-359410 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT58219 WP_000246253.1 NZ_CP013302:c360176-359904 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT58219 NZ_CP013302:c360176-359904 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2IC79

References