Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 207994..208760 Replicon chromosome
Accession NZ_CP013316
Organism Vibrio cholerae strain M2140

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag ASZ83_RS15505 Protein ID WP_000982260.1
Coordinates 207994..208491 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag ASZ83_RS15510 Protein ID WP_000246253.1
Coordinates 208488..208760 (-) Length 91 a.a.

Genomic Context

ASZ83_RS15450ASZ83_RS20210ASZ83_RS15460ASZ83_RS15465ASZ83_RS20215ASZ83_RS15475ASZ83_RS15480ASZ83_RS15485ASZ83_RS15490ASZ83_RS15500ASZ83_RS15515ASZ83_RS15520ASZ83_RS15525ASZ83_RS15530ASZ83_RS15535ASZ83_RS15540ASZ83_RS15545ASZ83_RS15550ASZ83_RS15505ASZ83_RS15510
Location: 203235..204164 (930 bp)
Type: Others
Protein ID: WP_000335802.1
Location: 204161..204271 (111 bp)
Type: Others
Protein ID: WP_071917832.1
Location: 204299..204991 (693 bp)
Type: Others
Protein ID: WP_001047177.1
Location: 204991..205392 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 205362..205505 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 205580..205993 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 206207..206458 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 206448..206735 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 206863..207318 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 207640..207792 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 208991..209659 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 209811..210098 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 210239..210610 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 210677..211102 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 211099..211632 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 211834..212091 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 212079..212381 (303 bp)
Type: Others
Protein ID: WP_000229317.1
Location: 212615..213532 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 207994..208491 (498 bp)
Type: Toxin
Protein ID: WP_000982260.1
Location: 208488..208760 (273 bp)
Type: Antitoxin
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ83_RS15450203235..204164+930WP_000335802.1hypothetical protein-
ASZ83_RS20210204161..204271+111WP_071917832.1DUF3265 domain-containing protein-
ASZ83_RS15460204299..204991+693WP_001047177.1GNAT family N-acetyltransferase-
ASZ83_RS15465204991..205392+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
ASZ83_RS20215205362..205505+144WP_071908341.1DUF3265 domain-containing protein-
ASZ83_RS15475205580..205993+414WP_000049417.1VOC family protein-
ASZ83_RS15480206207..206458+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
ASZ83_RS15485206448..206735+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
ASZ83_RS15490206863..207318+456WP_001245327.1GNAT family N-acetyltransferase-
ASZ83_RS15500207640..207792+153WP_001884520.1DUF645 family protein-
ASZ83_RS15505207994..208491-498WP_000982260.1GNAT family N-acetyltransferaseToxin
ASZ83_RS15510208488..208760-273WP_000246253.1DUF1778 domain-containing proteinAntitoxin
ASZ83_RS15515208991..209659+669WP_000043871.1hypothetical protein-
ASZ83_RS15520209811..210098+288WP_000426470.1hypothetical protein-
ASZ83_RS15525210239..210610+372WP_001164080.1nucleotide pyrophosphohydrolase-
ASZ83_RS15530210677..211102+426WP_001882332.1DUF1778 domain-containing protein-
ASZ83_RS15535211099..211632+534WP_000118351.1GNAT family N-acetyltransferase-
ASZ83_RS15540211834..212091+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
ASZ83_RS15545212079..212381+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxin-
ASZ83_RS15550212615..213532+918WP_000186333.1alpha/beta hydrolase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--87981..224211136230
insideIntegron--93061..221594128533


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T58384 WP_000982260.1 NZ_CP013316:c208491-207994 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T58384 NZ_CP013316:c208491-207994 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT58384 WP_000246253.1 NZ_CP013316:c208760-208488 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT58384 NZ_CP013316:c208760-208488 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0KGB1

Antitoxin

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Source
ID
Structure
PDB1Y9B
AlphaFold DBA0A0F2IC79

References