Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 456364..457130 Replicon chromosome
Accession NZ_CP013310
Organism Vibrio cholerae strain E1162

Toxin (Protein)


Gene name - Uniprot ID A0A233HKB4
Locus tag ASZ87_RS16425 Protein ID WP_000982256.1
Coordinates 456364..456861 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag ASZ87_RS16430 Protein ID WP_000246254.1
Coordinates 456858..457130 (-) Length 91 a.a.

Genomic Context

ASZ87_RS16390ASZ87_RS16395ASZ87_RS21055ASZ87_RS16400ASZ87_RS21155ASZ87_RS16410ASZ87_RS20515ASZ87_RS16420ASZ87_RS16435ASZ87_RS16440ASZ87_RS16450ASZ87_RS16455ASZ87_RS16460ASZ87_RS16465ASZ87_RS16470ASZ87_RS16480ASZ87_RS16425ASZ87_RS16430
Location: 451764..452303 (540 bp)
Type: Others
Protein ID: WP_053035032.1
Location: 452438..452863 (426 bp)
Type: Others
Protein ID: WP_000693748.1
Location: 452920..453030 (111 bp)
Type: Others
Protein ID: WP_106746893.1
Location: 453017..453376 (360 bp)
Type: Others
Protein ID: WP_001071527.1
Location: 453518..453951 (434 bp)
Type: Others
Protein ID: Protein_393
Location: 454088..455014 (927 bp)
Type: Others
Protein ID: WP_000377813.1
Location: 455337..455490 (154 bp)
Type: Others
Protein ID: Protein_395
Location: 455719..456222 (504 bp)
Type: Others
Protein ID: WP_001158950.1
Location: 457518..457685 (168 bp)
Type: Others
Protein ID: WP_053035038.1
Location: 457893..458240 (348 bp)
Type: Others
Protein ID: WP_000933413.1
Location: 458925..459107 (183 bp)
Type: Others
Protein ID: WP_000923340.1
Location: 459322..459861 (540 bp)
Type: Others
Protein ID: WP_000099372.1
Location: 459984..460499 (516 bp)
Type: Others
Protein ID: WP_000090011.1
Location: 460634..461170 (537 bp)
Type: Others
Protein ID: WP_000644491.1
Location: 461639..461749 (111 bp)
Type: Others
Protein ID: WP_071908335.1
Location: 461962..462114 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 456364..456861 (498 bp)
Type: Toxin
Protein ID: WP_000982256.1
Location: 456858..457130 (273 bp)
Type: Antitoxin
Protein ID: WP_000246254.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ87_RS16390451764..452303+540WP_053035032.1phosphoglycerate mutase family protein-
ASZ87_RS16395452438..452863+426WP_000693748.1hypothetical protein-
ASZ87_RS21055452920..453030+111WP_106746893.1iron transporter-
ASZ87_RS16400453017..453376+360WP_001071527.1VOC family protein-
ASZ87_RS21155453518..453951+434Protein_393GNAT family N-acetyltransferase-
ASZ87_RS16410454088..455014+927WP_000377813.1hypothetical protein-
ASZ87_RS20515455337..455490+154Protein_395DUF645 family protein-
ASZ87_RS16420455719..456222+504WP_001158950.1DinB family protein-
ASZ87_RS16425456364..456861-498WP_000982256.1GNAT family N-acetyltransferaseToxin
ASZ87_RS16430456858..457130-273WP_000246254.1DUF1778 domain-containing proteinAntitoxin
ASZ87_RS16435457518..457685+168WP_053035038.1DUF645 family protein-
ASZ87_RS16440457893..458240+348WP_000933413.1hypothetical protein-
ASZ87_RS16450458925..459107+183WP_000923340.1DUF645 family protein-
ASZ87_RS16455459322..459861+540WP_000099372.1hypothetical protein-
ASZ87_RS16460459984..460499+516WP_000090011.1hypothetical protein-
ASZ87_RS16465460634..461170+537WP_000644491.1nucleotidyltransferase family protein-
ASZ87_RS16470461639..461749+111WP_071908335.1DUF3265 domain-containing protein-
ASZ87_RS16480461962..462114+153WP_001884520.1DUF645 family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-435534..596659161125
insideIntegron--440614..596283155669


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(2-89)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18539.23 Da        Isoelectric Point: 8.7753

>T58301 WP_000982256.1 NZ_CP013310:c456861-456364 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGIEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T58301 NZ_CP013310:c456861-456364 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCATTGAAGCCCTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACACCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCTTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCGCTCAGAAAGCTACTCGCAGCCAGTGACAGCGTAGCGTTCCCTGTTGTGATCGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCTGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9685.19 Da        Isoelectric Point: 6.2988

>AT58301 WP_000246254.1 NZ_CP013310:c457130-456858 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLTKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVANAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT58301 NZ_CP013310:c457130-456858 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCACTAAGGCTGCTGCTCTTGC
TGGCATGTCTAGTATTAACTCATTTGTTTTGAATGCGGCAATTGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCGGTAGCAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A233HKB4

Antitoxin

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Source
ID
Structure
No matching records found

References