Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 432854..433413 Replicon chromosome II
Accession NC_016945
Organism Vibrio cholerae IEC224

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag O3Y_RS16285 Protein ID WP_000578476.1
Coordinates 432854..433132 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag O3Y_RS16290 Protein ID WP_000381183.1
Coordinates 433129..433413 (-) Length 95 a.a.

Genomic Context

O3Y_RS16250O3Y_RS16255O3Y_RS16260O3Y_RS16265O3Y_RS20350O3Y_RS16270O3Y_RS16275O3Y_RS20355O3Y_RS16280O3Y_RS16295O3Y_RS16300O3Y_RS16310O3Y_RS16285O3Y_RS16290
Location: 428154..428591 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 428655..428873 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 429048..429920 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 430070..430669 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 430726..430830 (105 bp)
Type: Others
Protein ID: WP_099607150.1
Location: 430861..431130 (270 bp)
Type: Others
Protein ID: WP_001114075.1
Location: 431124..431645 (522 bp)
Type: Others
Protein ID: WP_000921691.1
Location: 431944..432069 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 432320..432715 (396 bp)
Type: Others
Protein ID: WP_001000867.1
Location: 433607..434122 (516 bp)
Type: Others
Protein ID: WP_000343779.1
Location: 434306..434719 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 435274..436451 (1178 bp)
Type: Others
Protein ID: WP_086010879.1
Location: 432854..433132 (279 bp)
Type: Toxin
Protein ID: WP_000578476.1
Location: 433129..433413 (285 bp)
Type: Antitoxin
Protein ID: WP_000381183.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
O3Y_RS16250428154..428591+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
O3Y_RS16255428655..428873+219WP_071908318.1GNAT family N-acetyltransferase-
O3Y_RS16260429048..429920+873WP_000254716.1DUF3800 domain-containing protein-
O3Y_RS16265430070..430669+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
O3Y_RS20350430726..430830+105WP_099607150.1acetyltransferase-
O3Y_RS16270430861..431130+270WP_001114075.1DUF4160 domain-containing protein-
O3Y_RS16275431124..431645+522WP_000921691.1DUF2442 domain-containing protein-
O3Y_RS20355431944..432069+126WP_001905700.1DUF645 family protein-
O3Y_RS16280432320..432715+396WP_001000867.1hypothetical protein-
O3Y_RS16285432854..433132-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
O3Y_RS16290433129..433413-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
O3Y_RS16295433607..434122+516WP_000343779.1GNAT family N-acetyltransferase-
O3Y_RS16300434306..434719+414WP_000049420.1VOC family protein-
O3Y_RS16310435274..436451+1178WP_086010879.1IS3-like element ISVch4 family transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304637..435582130945
insideIntegron--309717..435206125489
flankIS/Tn--428154..428591437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T26160 WP_000578476.1 NC_016945:c433132-432854 [Vibrio cholerae IEC224]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T26160 NC_016945:c433132-432854 [Vibrio cholerae IEC224]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT26160 WP_000381183.1 NC_016945:c433413-433129 [Vibrio cholerae IEC224]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT26160 NC_016945:c433413-433129 [Vibrio cholerae IEC224]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9K2M8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A067BL33

References