Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 431996..432524 Replicon chromosome
Accession NZ_CP013314
Organism Vibrio cholerae strain E9120

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag ASZ79_RS16700 Protein ID WP_000221352.1
Coordinates 431996..432286 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag ASZ79_RS16705 Protein ID WP_000213183.1
Coordinates 432276..432524 (-) Length 83 a.a.

Genomic Context

ASZ79_RS21030ASZ79_RS21035ASZ79_RS16670ASZ79_RS16675ASZ79_RS16680ASZ79_RS20710ASZ79_RS16690ASZ79_RS16695ASZ79_RS16715ASZ79_RS16720ASZ79_RS16725ASZ79_RS16730ASZ79_RS16735ASZ79_RS16740ASZ79_RS16700ASZ79_RS16705ASZ79_RS16745
Location: 427553..427678 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 427694..427732 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 427945..428949 (1005 bp)
Type: Others
Protein ID: WP_000964925.1
Location: 429102..429548 (447 bp)
Type: Others
Protein ID: WP_000128977.1
Location: 429668..430597 (930 bp)
Type: Others
Protein ID: WP_000335802.1
Location: 430594..430704 (111 bp)
Type: Others
Protein ID: WP_071917832.1
Location: 430732..431208 (477 bp)
Type: Others
Protein ID: WP_001047180.1
Location: 431345..431860 (516 bp)
Type: Others
Protein ID: WP_001201528.1
Location: 433095..433748 (654 bp)
Type: Others
Protein ID: WP_000036957.1
Location: 434020..434445 (426 bp)
Type: Others
Protein ID: WP_000415748.1
Location: 434653..435048 (396 bp)
Type: Others
Protein ID: WP_000649527.1
Location: 435199..435729 (531 bp)
Type: Others
Protein ID: WP_000415563.1
Location: 435867..436367 (501 bp)
Type: Others
Protein ID: WP_000789723.1
Location: 436523..436921 (399 bp)
Type: Others
Protein ID: WP_001882293.1
Location: 431996..432286 (291 bp)
Type: Toxin
Protein ID: WP_000221352.1
Location: 432276..432524 (249 bp)
Type: Antitoxin
Protein ID: WP_000213183.1
Location: 437021..437485 (465 bp)
Type: Others
Protein ID: WP_000140244.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ79_RS21030427553..427678+126WP_001944767.1DUF645 family protein-
ASZ79_RS21035427694..427732+39WP_106019119.1hypothetical protein-
ASZ79_RS16670427945..428949+1005WP_000964925.1LD-carboxypeptidase-
ASZ79_RS16675429102..429548+447WP_000128977.1hypothetical protein-
ASZ79_RS16680429668..430597+930WP_000335802.1hypothetical protein-
ASZ79_RS20710430594..430704+111WP_071917832.1DUF3265 domain-containing protein-
ASZ79_RS16690430732..431208+477WP_001047180.1GNAT family N-acetyltransferase-
ASZ79_RS16695431345..431860+516WP_001201528.1lipocalin family protein-
ASZ79_RS16700431996..432286-291WP_000221352.1type II toxin-antitoxin system RelE/ParE family toxinToxin
ASZ79_RS16705432276..432524-249WP_000213183.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
ASZ79_RS16715433095..433748+654WP_000036957.1site-specific DNA-methyltransferase-
ASZ79_RS16720434020..434445+426WP_000415748.1hypothetical protein-
ASZ79_RS16725434653..435048+396WP_000649527.1DUF3465 domain-containing protein-
ASZ79_RS16730435199..435729+531WP_000415563.1hypothetical protein-
ASZ79_RS16735435867..436367+501WP_000789723.1hypothetical protein-
ASZ79_RS16740436523..436921+399WP_001882293.1hypothetical protein-
ASZ79_RS16745437021..437485-465WP_000140244.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304700..468464163764
insideIntegron--309780..468088158308


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T58361 WP_000221352.1 NZ_CP013314:c432286-431996 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T58361 NZ_CP013314:c432286-431996 [Vibrio cholerae]
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAGTTAGCCGTTCCACTCCAACAGCAGTTCAA
GAAGAAACTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCCAAACTGTCTGGCGCTGAGAACATTTATAAAATAA
AACTTCGGCAGTCTGGTTATCGCTTAGTCTATCAAGTTGAAAATGACATCATCGTAGTTACTGTTTTAGCTGTCGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT58361 WP_000213183.1 NZ_CP013314:c432524-432276 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT58361 NZ_CP013314:c432524-432276 [Vibrio cholerae]
ATGACCACTAGAATCCTAGCTGATGTTGCAGCAAGCATTACCGAATTTAAAGCAAACCCAATGAAAGTTGCAACTAGTGC
CTTCGGTGCTCCTGTTGCTGTACTCAACCGAAATGAGCCGGCTTTCTACTGCGTCCCTGCAAGCACCTACGAGATCATGA
TGGATAAGCTTGAAGATCTTGAGCTACTGGCTATTGCCAAAGAACGCTTAAGTGAAGACAGCGTATCGGTAAATATCGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBH9L4R3

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A366A3W8

References