211917

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 993750..994288 Replicon chromosome
Accession NZ_CP080466
Organism Vibrio cholerae strain ICDC-VC3741

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag K1T75_RS18290 Protein ID WP_000802136.1
Coordinates 993989..994288 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag K1T75_RS18285 Protein ID WP_001107719.1
Coordinates 993750..993992 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K1T75_RS18250 989166..989306 - 141 WP_001883049.1 DUF3265 domain-containing protein -
K1T75_RS18255 989272..990207 - 936 WP_000051985.1 restriction endonuclease -
K1T75_RS18260 990488..991087 - 600 WP_000429495.1 DUF6338 family protein -
K1T75_RS18265 991242..991508 - 267 WP_000937852.1 hypothetical protein -
K1T75_RS18270 991722..992405 - 684 WP_000877436.1 hypothetical protein -
K1T75_RS18275 992829..992921 - 93 WP_014164112.1 DUF3265 domain-containing protein -
K1T75_RS18280 992943..993521 - 579 WP_000110120.1 hypothetical protein -
K1T75_RS18285 993750..993992 + 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
K1T75_RS18290 993989..994288 + 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K1T75_RS18295 994416..994811 - 396 WP_000870857.1 DUF3465 domain-containing protein -
K1T75_RS18300 995025..995204 - 180 WP_001883058.1 DUF645 family protein -
K1T75_RS18305 995782..995871 - 90 WP_072606010.1 DUF3265 domain-containing protein -
K1T75_RS18310 995902..996600 - 699 WP_001890502.1 hypothetical protein -
K1T75_RS18315 996723..997349 - 627 WP_000365424.1 LysE family translocator -
K1T75_RS18320 997391..997483 - 93 WP_014378730.1 DUF3265 domain-containing protein -
K1T75_RS18325 997498..997971 - 474 WP_001161076.1 GrpB family protein -
K1T75_RS18330 998171..998353 - 183 WP_000923182.1 DUF645 family protein -
K1T75_RS18950 998414..998551 - 138 WP_001890145.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 932680..1039634 106954
inside Integron - - 933056..1032792 99736


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T211917 WP_000802136.1 NZ_CP080466:993989-994288 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T211917 NZ_CP106849:c890053-889709 [Edwardsiella ictaluri]
ATGAAGTCACTATATTGGGTTGGTAGTACAAAAAAAGACCTCCAGTCATTGCCTGAAGAAGTACAGGATATTTTCGGCTA
TGCCCTGCATCTGGCACAGGTAGGAGGTAAACACTCACAGACCAAGCCACTGAAGGGGTTTAGTGGAGCTGGCGTACTTG
AGGTAGTAGAAGACTTTCTCGGTGATACTTATCGTGCAGTGTATACCGTTAAGTTCGGTGATGCCGTCTACGTTTCGCAC
GTATTCCAGAAAAAGTCTTCATCGGGAATCGCCACGCCAAAGCTCAATATGGACAAGATCCGCGAACGGCTAAAAGCCGC
AGAAAACCATGCCAGAGGAGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT211917 WP_001107719.1 NZ_CP080466:993750-993992 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT211917 NZ_CP106849:c889707-889390 [Edwardsiella ictaluri]
ATGAGCCATGATATTGAAGTCAGCAGCGGCAACGTTTATGTCGATATTGGCAGAGATGATGCCGAGGAAATGCTGTTAAA
AGCTCAGCTTGCCACCACTATTGGAAACATCATTAAAAGCCGTAGCCTGACGCAAGAACAAGCAGCAAAACTGCTGGGGA
TGACGCAGCCCAAACTGTCCAATATGCTGCGTGGGCAGTTCCGGGGCATCAGTGAAGCCAAAATGCTGGAATGTCTGACC
CGCTTAGGGCGCGACGTGCAAATCGTGGTTGGAAAGCCGCGCCGGACGCCGGGTAGCGTGAAAGTAGTGTTAGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7R5A

Antitoxin

Source ID Structure
AlphaFold DB A0A151JFU4

References