Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 993750..994288 Replicon chromosome
Accession NZ_CP080466
Organism Vibrio cholerae strain ICDC-VC3741

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag K1T75_RS18290 Protein ID WP_000802136.1
Coordinates 993989..994288 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag K1T75_RS18285 Protein ID WP_001107719.1
Coordinates 993750..993992 (+) Length 81 a.a.

Genomic Context

K1T75_RS18285K1T75_RS18290K1T75_RS18250K1T75_RS18255K1T75_RS18260K1T75_RS18265K1T75_RS18270K1T75_RS18275K1T75_RS18280K1T75_RS18295K1T75_RS18300K1T75_RS18305K1T75_RS18310K1T75_RS18315K1T75_RS18320K1T75_RS18325K1T75_RS18330K1T75_RS18950
Location: 993750..993992 (243 bp)
Type: Antitoxin
Protein ID: WP_001107719.1
Location: 993989..994288 (300 bp)
Type: Toxin
Protein ID: WP_000802136.1
Location: 989166..989306 (141 bp)
Type: Others
Protein ID: WP_001883049.1
Location: 989272..990207 (936 bp)
Type: Others
Protein ID: WP_000051985.1
Location: 990488..991087 (600 bp)
Type: Others
Protein ID: WP_000429495.1
Location: 991242..991508 (267 bp)
Type: Others
Protein ID: WP_000937852.1
Location: 991722..992405 (684 bp)
Type: Others
Protein ID: WP_000877436.1
Location: 992829..992921 (93 bp)
Type: Others
Protein ID: WP_014164112.1
Location: 992943..993521 (579 bp)
Type: Others
Protein ID: WP_000110120.1
Location: 994416..994811 (396 bp)
Type: Others
Protein ID: WP_000870857.1
Location: 995025..995204 (180 bp)
Type: Others
Protein ID: WP_001883058.1
Location: 995782..995871 (90 bp)
Type: Others
Protein ID: WP_072606010.1
Location: 995902..996600 (699 bp)
Type: Others
Protein ID: WP_001890502.1
Location: 996723..997349 (627 bp)
Type: Others
Protein ID: WP_000365424.1
Location: 997391..997483 (93 bp)
Type: Others
Protein ID: WP_014378730.1
Location: 997498..997971 (474 bp)
Type: Others
Protein ID: WP_001161076.1
Location: 998171..998353 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 998414..998551 (138 bp)
Type: Others
Protein ID: WP_001890145.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K1T75_RS18250989166..989306-141WP_001883049.1DUF3265 domain-containing protein-
K1T75_RS18255989272..990207-936WP_000051985.1restriction endonuclease-
K1T75_RS18260990488..991087-600WP_000429495.1DUF6338 family protein-
K1T75_RS18265991242..991508-267WP_000937852.1hypothetical protein-
K1T75_RS18270991722..992405-684WP_000877436.1hypothetical protein-
K1T75_RS18275992829..992921-93WP_014164112.1DUF3265 domain-containing protein-
K1T75_RS18280992943..993521-579WP_000110120.1hypothetical protein-
K1T75_RS18285993750..993992+243WP_001107719.1type II toxin-antitoxin system ParD family antitoxinAntitoxin
K1T75_RS18290993989..994288+300WP_000802136.1type II toxin-antitoxin system RelE/ParE family toxinToxin
K1T75_RS18295994416..994811-396WP_000870857.1DUF3465 domain-containing protein-
K1T75_RS18300995025..995204-180WP_001883058.1DUF645 family protein-
K1T75_RS18305995782..995871-90WP_072606010.1DUF3265 domain-containing protein-
K1T75_RS18310995902..996600-699WP_001890502.1hypothetical protein-
K1T75_RS18315996723..997349-627WP_000365424.1LysE family translocator-
K1T75_RS18320997391..997483-93WP_014378730.1DUF3265 domain-containing protein-
K1T75_RS18325997498..997971-474WP_001161076.1GrpB family protein-
K1T75_RS18330998171..998353-183WP_000923182.1DUF645 family protein-
K1T75_RS18950998414..998551-138WP_001890145.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-932680..1039634106954
insideIntegron--933056..103279299736


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T211917 WP_000802136.1 NZ_CP080466:993989-994288 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T211917 NZ_CP106849:c890053-889709 [Edwardsiella ictaluri]
ATGAAGTCACTATATTGGGTTGGTAGTACAAAAAAAGACCTCCAGTCATTGCCTGAAGAAGTACAGGATATTTTCGGCTA
TGCCCTGCATCTGGCACAGGTAGGAGGTAAACACTCACAGACCAAGCCACTGAAGGGGTTTAGTGGAGCTGGCGTACTTG
AGGTAGTAGAAGACTTTCTCGGTGATACTTATCGTGCAGTGTATACCGTTAAGTTCGGTGATGCCGTCTACGTTTCGCAC
GTATTCCAGAAAAAGTCTTCATCGGGAATCGCCACGCCAAAGCTCAATATGGACAAGATCCGCGAACGGCTAAAAGCCGC
AGAAAACCATGCCAGAGGAGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT211917 WP_001107719.1 NZ_CP080466:993750-993992 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT211917 NZ_CP106849:c889707-889390 [Edwardsiella ictaluri]
ATGAGCCATGATATTGAAGTCAGCAGCGGCAACGTTTATGTCGATATTGGCAGAGATGATGCCGAGGAAATGCTGTTAAA
AGCTCAGCTTGCCACCACTATTGGAAACATCATTAAAAGCCGTAGCCTGACGCAAGAACAAGCAGCAAAACTGCTGGGGA
TGACGCAGCCCAAACTGTCCAATATGCTGCGTGGGCAGTTCCGGGGCATCAGTGAAGCCAAAATGCTGGAATGTCTGACC
CGCTTAGGGCGCGACGTGCAAATCGTGGTTGGAAAGCCGCGCCGGACGCCGGGTAGCGTGAAAGTAGTGTTAGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB7R5A

Antitoxin

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Source
ID
Structure
PDB7R5A
PDB7B22
AlphaFold DBA0A151JFU4

References