Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 222332..222879 Replicon chromosome
Accession NZ_AP024554
Organism Vibrio cholerae strain IDH-03329

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag K6J80_RS14865 Protein ID WP_000229317.1
Coordinates 222332..222634 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag K6J80_RS14870 Protein ID WP_000861987.1
Coordinates 222622..222879 (-) Length 86 a.a.

Genomic Context

K6J80_RS14900K6J80_RS14905K6J80_RS14825K6J80_RS14830K6J80_RS14835K6J80_RS14840K6J80_RS14845K6J80_RS14850K6J80_RS14855K6J80_RS14860K6J80_RS14865K6J80_RS14870K6J80_RS18935K6J80_RS14875K6J80_RS18940K6J80_RS14885K6J80_RS14890K6J80_RS14895K6J80_RS18945K6J80_RS18950K6J80_RS14910K6J80_RS18955K6J80_RS14915
Location: 225953..226225 (273 bp)
Type: Others
Protein ID: WP_000246253.1
Location: 226222..226719 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 217531..217599 (69 bp)
Type: Others
Protein ID: Protein_190
Location: 217656..218255 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 218405..219277 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 219452..219673 (222 bp)
Type: Others
Protein ID: Protein_193
Location: 219734..220171 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 220290..220499 (210 bp)
Type: Others
Protein ID: Protein_195
Location: 220635..221024 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 221181..222098 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 222332..222634 (303 bp)
Type: Toxin
Protein ID: WP_000229317.1
Location: 222622..222879 (258 bp)
Type: Antitoxin
Protein ID: WP_000861987.1
Location: 222961..223071 (111 bp)
Type: Others
Protein ID: WP_086010065.1
Location: 223081..223614 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 223611..223880 (270 bp)
Type: Others
Protein ID: WP_000179600.1
Location: 224103..224474 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 224615..224902 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 225054..225722 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 225739..225801 (63 bp)
Type: Others
Protein ID: Protein_206
Location: 226736..226804 (69 bp)
Type: Others
Protein ID: Protein_209
Location: 226921..227025 (105 bp)
Type: Others
Protein ID: WP_228840819.1
Location: 227216..227338 (123 bp)
Type: Others
Protein ID: Protein_211
Location: 227395..227850 (456 bp)
Type: Others
Protein ID: WP_001245327.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K6J80_RS14825217531..217599-69Protein_190acetyltransferase-
K6J80_RS14830217656..218255-600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
K6J80_RS14835218405..219277-873WP_000254716.1DUF3800 domain-containing protein-
K6J80_RS14840219452..219673-222Protein_193GNAT family N-acetyltransferase-
K6J80_RS14845219734..220171-438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
K6J80_RS14850220290..220499-210Protein_195GNAT family N-acetyltransferase-
K6J80_RS14855220635..221024-390WP_001081302.1hypothetical protein-
K6J80_RS14860221181..222098-918WP_000186333.1alpha/beta hydrolase-
K6J80_RS14865222332..222634-303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxinToxin
K6J80_RS14870222622..222879-258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
K6J80_RS18935222961..223071-111WP_086010065.1DUF3265 domain-containing protein-
K6J80_RS14875223081..223614-534WP_000118351.1GNAT family N-acetyltransferase-
K6J80_RS18940223611..223880-270WP_000179600.1DUF1778 domain-containing protein-
K6J80_RS14885224103..224474-372WP_001164080.1MazG nucleotide pyrophosphohydrolase domain-containing protein-
K6J80_RS14890224615..224902-288WP_000426470.1hypothetical protein-
K6J80_RS14895225054..225722-669WP_000043871.1hypothetical protein-
K6J80_RS18945225739..225801-63Protein_206acetyltransferase-
K6J80_RS14900225953..226225+273WP_000246253.1DUF1778 domain-containing protein-
K6J80_RS14905226222..226719+498WP_000982260.1GNAT family N-acetyltransferase-
K6J80_RS18950226736..226804-69Protein_209acetyltransferase-
K6J80_RS14910226921..227025-105WP_228840819.1DUF645 family protein-
K6J80_RS18955227216..227338-123Protein_211acetyltransferase-
K6J80_RS14915227395..227850-456WP_001245327.1GNAT family N-acetyltransferase-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-213119..319686106567
insideIntegron--213119..31285699737
flankIS/Tn--219734..220171437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T38670 WP_000229317.1 NZ_AP024554:c222634-222332 [Vibrio cholerae]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T38670 NZ_AP024554:c222634-222332 [Vibrio cholerae]
ATGGTTGAAATAATTTGGACGGAGCTGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAGTCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT38670 WP_000861987.1 NZ_AP024554:c222879-222622 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT38670 NZ_AP024554:c222879-222622 [Vibrio cholerae]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBQ9KM92

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A1T4SLM9

References