38670

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 222332..222879 Replicon chromosome
Accession NZ_AP024554
Organism Vibrio cholerae strain IDH-03329

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag K6J80_RS14865 Protein ID WP_000229317.1
Coordinates 222332..222634 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag K6J80_RS14870 Protein ID WP_000861987.1
Coordinates 222622..222879 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J80_RS14825 217531..217599 - 69 Protein_190 acetyltransferase -
K6J80_RS14830 217656..218255 - 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
K6J80_RS14835 218405..219277 - 873 WP_000254716.1 DUF3800 domain-containing protein -
K6J80_RS14840 219452..219673 - 222 Protein_193 GNAT family N-acetyltransferase -
K6J80_RS14845 219734..220171 - 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
K6J80_RS14850 220290..220499 - 210 Protein_195 GNAT family N-acetyltransferase -
K6J80_RS14855 220635..221024 - 390 WP_001081302.1 hypothetical protein -
K6J80_RS14860 221181..222098 - 918 WP_000186333.1 alpha/beta hydrolase -
K6J80_RS14865 222332..222634 - 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6J80_RS14870 222622..222879 - 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K6J80_RS18935 222961..223071 - 111 WP_086010065.1 DUF3265 domain-containing protein -
K6J80_RS14875 223081..223614 - 534 WP_000118351.1 GNAT family N-acetyltransferase -
K6J80_RS18940 223611..223880 - 270 WP_000179600.1 DUF1778 domain-containing protein -
K6J80_RS14885 224103..224474 - 372 WP_001164080.1 MazG nucleotide pyrophosphohydrolase domain-containing protein -
K6J80_RS14890 224615..224902 - 288 WP_000426470.1 hypothetical protein -
K6J80_RS14895 225054..225722 - 669 WP_000043871.1 hypothetical protein -
K6J80_RS18945 225739..225801 - 63 Protein_206 acetyltransferase -
K6J80_RS14900 225953..226225 + 273 WP_000246253.1 DUF1778 domain-containing protein -
K6J80_RS14905 226222..226719 + 498 WP_000982260.1 GNAT family N-acetyltransferase -
K6J80_RS18950 226736..226804 - 69 Protein_209 acetyltransferase -
K6J80_RS14910 226921..227025 - 105 WP_228840819.1 DUF645 family protein -
K6J80_RS18955 227216..227338 - 123 Protein_211 acetyltransferase -
K6J80_RS14915 227395..227850 - 456 WP_001245327.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 213119..319686 106567
inside Integron - - 213119..312856 99737
flank IS/Tn - - 219734..220171 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T38670 WP_000229317.1 NZ_AP024554:c222634-222332 [Vibrio cholerae]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T38670 NZ_AP024554:c222634-222332 [Vibrio cholerae]
ATGGTTGAAATAATTTGGACGGAGCTGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAGTCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT38670 WP_000861987.1 NZ_AP024554:c222879-222622 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT38670 NZ_AP024554:c222879-222622 [Vibrio cholerae]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9KM92

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SLM9

References