145059

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 331645..332192 Replicon chromosome
Accession NZ_CP046841
Organism Vibrio cholerae strain F9993

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag GPY07_RS15795 Protein ID WP_000229317.1
Coordinates 331645..331947 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag GPY07_RS15800 Protein ID WP_000861987.1
Coordinates 331935..332192 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPY07_RS15755 326808..326912 - 105 WP_099607150.1 acetyltransferase -
GPY07_RS15760 326969..327568 - 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
GPY07_RS15765 327718..328590 - 873 WP_000254716.1 DUF3800 domain-containing protein -
GPY07_RS15770 328765..328983 - 219 WP_071908318.1 GNAT family N-acetyltransferase -
GPY07_RS15775 329047..329484 - 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
GPY07_RS15780 329603..329812 - 210 Protein_290 GNAT family N-acetyltransferase -
GPY07_RS15785 329948..330337 - 390 WP_001081302.1 hypothetical protein -
GPY07_RS15790 330494..331411 - 918 WP_000186333.1 alpha/beta hydrolase -
GPY07_RS15795 331645..331947 - 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GPY07_RS15800 331935..332192 - 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GPY07_RS15810 332394..332927 - 534 WP_000118351.1 GNAT family N-acetyltransferase -
GPY07_RS19430 332924..333349 - 426 WP_001882332.1 DUF1778 domain-containing protein -
GPY07_RS15820 333416..333787 - 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
GPY07_RS15825 333928..334215 - 288 WP_000426470.1 hypothetical protein -
GPY07_RS15830 334367..335035 - 669 WP_000043871.1 hypothetical protein -
GPY07_RS15835 335266..335538 + 273 WP_000246253.1 DUF1778 domain-containing protein -
GPY07_RS15840 335535..336032 + 498 WP_000982260.1 GNAT family N-acetyltransferase -
GPY07_RS15850 336234..336386 - 153 WP_001884520.1 DUF645 family protein -
GPY07_RS15855 336708..337163 - 456 WP_001245327.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 322056..419024 96968
inside Integron - - 322432..412236 89804
flank IS/Tn - - 329047..329484 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T145059 WP_000229317.1 NZ_CP046841:c331947-331645 [Vibrio cholerae]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T145059 NZ_CP062252:496210-496497 [Pseudomonas allokribbensis]
ATGACCGAACAATTCACTCGTTGGGACTCAGCCGAGTACCTCAAGACAGAAGAGGACATGGCCAACTATCTGGACGCCTG
TATGGAAGAGGCGGGTGACGACCCGGCTTTTATTGCCAAGGCACTTGGCACTATCGCTCGGGCGCGTGGCATGACGCAGG
TTGCGCGCGATGCTGGGCTATCAAGGGAAAGTCTTTATCGCGCACTGTCAGGCGAGGTAAATCCTGAGTTTGGGACGATC
CTCAAAGTCATGAAGGCGCTGGGGCTGAAGTTGCATGCCAGCACATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT145059 WP_000861987.1 NZ_CP046841:c332192-331935 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT145059 NZ_CP062252:495908-496213 [Pseudomonas allokribbensis]
ATGACTGAGATACTTCGAAGCTCCACATTCTCGAGCTGGCTTGTGAAGCTGGCTGATAGTCGCGCCAGGATGCGTATTCA
GGTGCGAATTGATCGCATGGCTGATGGGAATTTCGGTGATGTCAAAGCCATTGGCGAAGGGATCAGCGAAGCCCGAATTG
ACTATGGCCCGGGATATCGGGTCTATTTCATGCTGCAAGGTCGTCAGCTGGTCATCCTCCTTTGTGGTGGAGACAAGAGC
AGTCAATCTCGAGACATCAAGCAAGCCAGGCTCATAGCGGAATCCTGGCAGGAGCAAAACCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9KM92

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SLM9

References