145847

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 346769..347328 Replicon chromosome
Accession NZ_CP047300
Organism Vibrio cholerae O1 biovar El Tor strain P27459

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag GTF71_RS15080 Protein ID WP_000578476.1
Coordinates 346769..347047 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag GTF71_RS15085 Protein ID WP_000381183.1
Coordinates 347044..347328 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTF71_RS15030 341847..342353 + 507 WP_000393074.1 hypothetical protein -
GTF71_RS15035 342510..342896 + 387 WP_000703163.1 VOC family protein -
GTF71_RS15040 343153..343356 + 204 WP_001911580.1 hypothetical protein -
GTF71_RS15045 343551..343802 + 252 WP_001890111.1 TIGR03643 family protein -
GTF71_RS15050 343775..343924 + 150 WP_071908333.1 DUF3265 domain-containing protein -
GTF71_RS15055 344071..344496 + 426 WP_000415750.1 hypothetical protein -
GTF71_RS15060 344702..345325 + 624 WP_000247070.1 DUF1349 domain-containing protein -
GTF71_RS15065 345538..346017 + 480 WP_000009888.1 lecithin retinol acyltransferase family protein -
GTF71_RS15070 346205..346618 + 414 WP_000049420.1 VOC family protein -
GTF71_RS15075 346625..346720 - 96 Protein_325 hypothetical protein -
GTF71_RS15080 346769..347047 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
GTF71_RS15085 347044..347328 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GTF71_RS15090 347523..348038 + 516 WP_001201520.1 lipocalin family protein -
GTF71_RS15095 348103..348699 + 597 WP_000255434.1 hypothetical protein -
GTF71_RS15100 349091..349273 + 183 WP_000923182.1 DUF645 family protein -
GTF71_RS15105 349473..349946 + 474 WP_001161076.1 GrpB family protein -
GTF71_RS15110 349943..350053 + 111 WP_071908312.1 DUF3265 domain-containing protein -
GTF71_RS15115 350095..350721 + 627 WP_000365424.1 LysE family translocator -
GTF71_RS15120 350844..351542 + 699 WP_001890502.1 hypothetical protein -
GTF71_RS15125 351546..351662 + 117 WP_071908339.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306926..439292 132366
inside Integron - - 312006..438916 126910


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T145847 WP_000578476.1 NZ_CP047300:c347047-346769 [Vibrio cholerae O1 biovar El Tor]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T145847 NZ_CP062702:c3469016-3468861 [Escherichia coli O157:H7]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAGTCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT145847 WP_000381183.1 NZ_CP047300:c347328-347044 [Vibrio cholerae O1 biovar El Tor]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT145847 NZ_CP062702:3469028-3469086 [Escherichia coli O157:H7]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9K2M8

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References