Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 346769..347328 Replicon chromosome
Accession NZ_CP047300
Organism Vibrio cholerae O1 biovar El Tor strain P27459

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag GTF71_RS15080 Protein ID WP_000578476.1
Coordinates 346769..347047 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag GTF71_RS15085 Protein ID WP_000381183.1
Coordinates 347044..347328 (-) Length 95 a.a.

Genomic Context

GTF71_RS15030GTF71_RS15035GTF71_RS15040GTF71_RS15045GTF71_RS15050GTF71_RS15055GTF71_RS15060GTF71_RS15065GTF71_RS15070GTF71_RS15090GTF71_RS15095GTF71_RS15100GTF71_RS15105GTF71_RS15110GTF71_RS15115GTF71_RS15120GTF71_RS15125GTF71_RS15075GTF71_RS15080GTF71_RS15085
Location: 341847..342353 (507 bp)
Type: Others
Protein ID: WP_000393074.1
Location: 342510..342896 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 343153..343356 (204 bp)
Type: Others
Protein ID: WP_001911580.1
Location: 343551..343802 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 343775..343924 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 344071..344496 (426 bp)
Type: Others
Protein ID: WP_000415750.1
Location: 344702..345325 (624 bp)
Type: Others
Protein ID: WP_000247070.1
Location: 345538..346017 (480 bp)
Type: Others
Protein ID: WP_000009888.1
Location: 346205..346618 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 347523..348038 (516 bp)
Type: Others
Protein ID: WP_001201520.1
Location: 348103..348699 (597 bp)
Type: Others
Protein ID: WP_000255434.1
Location: 349091..349273 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 349473..349946 (474 bp)
Type: Others
Protein ID: WP_001161076.1
Location: 349943..350053 (111 bp)
Type: Others
Protein ID: WP_071908312.1
Location: 350095..350721 (627 bp)
Type: Others
Protein ID: WP_000365424.1
Location: 350844..351542 (699 bp)
Type: Others
Protein ID: WP_001890502.1
Location: 351546..351662 (117 bp)
Type: Others
Protein ID: WP_071908339.1
Location: 346625..346720 (96 bp)
Type: Others
Protein ID: Protein_325
Location: 346769..347047 (279 bp)
Type: Toxin
Protein ID: WP_000578476.1
Location: 347044..347328 (285 bp)
Type: Antitoxin
Protein ID: WP_000381183.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GTF71_RS15030341847..342353+507WP_000393074.1hypothetical protein-
GTF71_RS15035342510..342896+387WP_000703163.1VOC family protein-
GTF71_RS15040343153..343356+204WP_001911580.1hypothetical protein-
GTF71_RS15045343551..343802+252WP_001890111.1TIGR03643 family protein-
GTF71_RS15050343775..343924+150WP_071908333.1DUF3265 domain-containing protein-
GTF71_RS15055344071..344496+426WP_000415750.1hypothetical protein-
GTF71_RS15060344702..345325+624WP_000247070.1DUF1349 domain-containing protein-
GTF71_RS15065345538..346017+480WP_000009888.1lecithin retinol acyltransferase family protein-
GTF71_RS15070346205..346618+414WP_000049420.1VOC family protein-
GTF71_RS15075346625..346720-96Protein_325hypothetical protein-
GTF71_RS15080346769..347047-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
GTF71_RS15085347044..347328-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
GTF71_RS15090347523..348038+516WP_001201520.1lipocalin family protein-
GTF71_RS15095348103..348699+597WP_000255434.1hypothetical protein-
GTF71_RS15100349091..349273+183WP_000923182.1DUF645 family protein-
GTF71_RS15105349473..349946+474WP_001161076.1GrpB family protein-
GTF71_RS15110349943..350053+111WP_071908312.1DUF3265 domain-containing protein-
GTF71_RS15115350095..350721+627WP_000365424.1LysE family translocator-
GTF71_RS15120350844..351542+699WP_001890502.1hypothetical protein-
GTF71_RS15125351546..351662+117WP_071908339.1DUF3265 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-306926..439292132366
insideIntegron--312006..438916126910


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T145847 WP_000578476.1 NZ_CP047300:c347047-346769 [Vibrio cholerae O1 biovar El Tor]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T145847 NZ_CP062702:c3469016-3468861 [Escherichia coli O157:H7]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAGTCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT145847 WP_000381183.1 NZ_CP047300:c347328-347044 [Vibrio cholerae O1 biovar El Tor]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT145847 NZ_CP062702:3469028-3469086 [Escherichia coli O157:H7]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9K2M8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A067BL33

References