58268

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 383197..383735 Replicon chromosome
Accession NZ_CP013306
Organism Vibrio cholerae strain CRC1106

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag ASZ81_RS16320 Protein ID WP_000802136.1
Coordinates 383197..383496 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag ASZ81_RS16325 Protein ID WP_001107719.1
Coordinates 383493..383735 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ81_RS16270 379132..379314 + 183 WP_000923182.1 DUF645 family protein -
ASZ81_RS16275 379514..379987 + 474 WP_001161076.1 GrpB family protein -
ASZ81_RS16280 380002..380094 + 93 WP_014378730.1 DUF3265 domain-containing protein -
ASZ81_RS16285 380136..380762 + 627 WP_000365424.1 LysE family translocator -
ASZ81_RS16290 380885..381583 + 699 WP_001890502.1 hypothetical protein -
ASZ81_RS16295 381593..381703 + 111 WP_079857360.1 DUF3265 domain-containing protein -
ASZ81_RS16310 382281..382460 + 180 WP_001883058.1 DUF645 family protein -
ASZ81_RS16315 382674..383069 + 396 WP_000870857.1 DUF3465 domain-containing protein -
ASZ81_RS16320 383197..383496 - 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ASZ81_RS16325 383493..383735 - 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
ASZ81_RS16330 383964..384542 + 579 WP_000110120.1 hypothetical protein -
ASZ81_RS16335 384564..384656 + 93 WP_014164112.1 DUF3265 domain-containing protein -
ASZ81_RS16345 385080..385763 + 684 WP_000877436.1 hypothetical protein -
ASZ81_RS16350 385977..386243 + 267 WP_000937852.1 hypothetical protein -
ASZ81_RS16355 386398..386997 + 600 WP_000429495.1 hypothetical protein -
ASZ81_RS16360 387278..388213 + 936 WP_000051985.1 restriction endonuclease -
ASZ81_RS16365 388179..388319 + 141 WP_001883049.1 DUF3265 domain-containing protein -
ASZ81_RS16370 388329..388724 + 396 WP_000046952.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304741..463550 158809
inside Integron - - 309821..463174 153353


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T58268 WP_000802136.1 NZ_CP013306:c383496-383197 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T58268 NZ_CP013306:c383496-383197 [Vibrio cholerae]
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT58268 WP_001107719.1 NZ_CP013306:c383735-383493 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT58268 NZ_CP013306:c383735-383493 [Vibrio cholerae]
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGGCGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7R5A

Antitoxin

Source ID Structure
AlphaFold DB A0A151JFU4

References