104336

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 326758..327524 Replicon chromosome
Accession NZ_CP028895
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag A1552VC_RS15765 Protein ID WP_000982260.1
Coordinates 326758..327255 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag A1552VC_RS15770 Protein ID WP_000246253.1
Coordinates 327252..327524 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A1552VC_RS15705 322200..322904 + 705 WP_000087610.1 HNH endonuclease -
A1552VC_RS15710 323062..323400 + 339 WP_000713853.1 hypothetical protein -
A1552VC_RS15720 323554..323871 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin -
A1552VC_RS15725 323890..324132 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
A1552VC_RS15730 324376..324762 + 387 WP_001015867.1 NUDIX hydrolase -
A1552VC_RS15735 324819..324932 + 114 WP_001900214.1 hypothetical protein -
A1552VC_RS15740 324881..325162 + 282 WP_001894429.1 DUF1289 domain-containing protein -
A1552VC_RS15755 325420..325956 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
A1552VC_RS15760 326093..326608 + 516 WP_001201509.1 lipocalin family protein -
A1552VC_RS15765 326758..327255 - 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
A1552VC_RS15770 327252..327524 - 273 WP_000246253.1 DUF1778 domain-containing protein Antitoxin
A1552VC_RS15775 327917..328042 + 126 WP_001900195.1 DUF645 family protein -
A1552VC_RS15780 328058..328096 + 39 WP_106019118.1 hypothetical protein -
A1552VC_RS15790 328292..328738 + 447 WP_000006157.1 hypothetical protein -
A1552VC_RS15795 328886..329155 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin -
A1552VC_RS15800 329148..329426 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
A1552VC_RS15810 329712..329990 + 279 WP_001921601.1 DUF3709 domain-containing protein -
A1552VC_RS15815 330242..330448 + 207 Protein_292 DUF3709 domain-containing protein -
A1552VC_RS15820 330648..330749 + 102 WP_001921603.1 hypothetical protein -
A1552VC_RS15825 330739..331125 + 387 WP_000703163.1 VOC family protein -
A1552VC_RS15830 331320..331571 + 252 WP_001890111.1 TIGR03643 family protein -
A1552VC_RS15835 331544..331693 + 150 WP_071908333.1 DUF3265 domain-containing protein -
A1552VC_RS15840 331785..332027 + 243 WP_000107461.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306914..436175 129261
inside Integron - - 311994..435799 123805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T104336 WP_000982260.1 NZ_CP028895:c327255-326758 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T104336 NZ_CP028895:c327255-326758 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT104336 WP_000246253.1 NZ_CP028895:c327524-327252 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT104336 NZ_CP028895:c327524-327252 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2IC79

References