Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 417259..417892 Replicon chromosome
Accession NZ_CP028828
Organism Vibrio cholerae strain N16961

Toxin (Protein)


Gene name higB Uniprot ID Q9KMA6
Locus tag N16961_RS16520 Protein ID WP_000843587.1
Coordinates 417259..417591 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N16961_RS16525 Protein ID WP_000071008.1
Coordinates 417578..417892 (+) Length 105 a.a.

Genomic Context

N16961_RS19765N16961_RS16450N16961_RS16455N16961_RS19940N16961_RS16470N16961_RS16475N16961_RS16480N16961_RS19945N16961_RS16485N16961_RS16500N16961_RS16505N16961_RS16520N16961_RS16525N16961_RS16530N16961_RS19670N16961_RS16540N16961_RS16545N16961_RS16550N16961_RS16555N16961_RS16560N16961_RS16565N16961_RS16570N16961_RS16535
Location: 412700..412903 (204 bp)
Type: Others
Protein ID: WP_001911745.1
Location: 413184..413357 (174 bp)
Type: Others
Protein ID: WP_001882305.1
Location: 413717..413986 (270 bp)
Type: Others
Protein ID: WP_001198131.1
Location: 414304..414475 (172 bp)
Type: Others
Protein ID: Protein_435
Location: 414684..415070 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 415272..415514 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 415685..416062 (378 bp)
Type: Others
Protein ID: WP_000411109.1
Location: 416119..416233 (115 bp)
Type: Others
Protein ID: Protein_439
Location: 416182..416463 (282 bp)
Type: Others
Protein ID: WP_001894453.1
Location: 416629..416742 (114 bp)
Type: Others
Protein ID: WP_001889158.1
Location: 416691..416918 (228 bp)
Type: Others
Protein ID: WP_001894457.1
Location: 417259..417591 (333 bp)
Type: Toxin
Protein ID: WP_000843587.1
Location: 417578..417892 (315 bp)
Type: Antitoxin
Protein ID: WP_000071008.1
Location: 418029..418463 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 418631..418786 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 419959..420265 (307 bp)
Type: Others
Protein ID: Protein_448
Location: 420402..421094 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 421094..421495 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 421465..421608 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 421683..422096 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 422310..422561 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 422551..422838 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 418911..419891 (981 bp)
Type: Others
Protein ID: WP_000019370.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
N16961_RS19765412700..412903+204WP_001911745.1hypothetical protein-
N16961_RS16450413184..413357+174WP_001882305.1DUF3709 domain-containing protein-
N16961_RS16455413717..413986+270WP_001198131.1hypothetical protein-
N16961_RS19940414304..414475+172Protein_435DUF645 family protein-
N16961_RS16470414684..415070+387WP_000703163.1VOC family protein-
N16961_RS16475415272..415514+243WP_000107461.1hypothetical protein-
N16961_RS16480415685..416062+378WP_000411109.1hypothetical protein-
N16961_RS19945416119..416233+115Protein_439acetyltransferase-
N16961_RS16485416182..416463+282WP_001894453.1DUF1289 domain-containing protein-
N16961_RS16500416629..416742+114WP_001889158.1hypothetical protein-
N16961_RS16505416691..416918+228WP_001894457.1DUF1289 domain-containing protein-
N16961_RS16520417259..417591+333WP_000843587.1type II toxin-antitoxin system RelE/ParE family toxinToxin
N16961_RS16525417578..417892+315WP_000071008.1DNA-binding transcriptional regulatorAntitoxin
N16961_RS16530418029..418463+435WP_000256036.1GNAT family N-acetyltransferase-
N16961_RS19670418631..418786+156WP_000751734.1hypothetical protein-
N16961_RS16535418911..419891-981WP_000019370.1IS5-like element ISVch5 family transposase-
N16961_RS16540419959..420265+307Protein_448CatB-related O-acetyltransferase-
N16961_RS16545420402..421094+693WP_001047169.1GNAT family N-acetyltransferase-
N16961_RS16550421094..421495+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
N16961_RS16555421465..421608+144WP_071908341.1DUF3265 domain-containing protein-
N16961_RS16560421683..422096+414WP_000049417.1VOC family protein-
N16961_RS16565422310..422561+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
N16961_RS16570422551..422838+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-306977..438073131096
insideIntegron--312057..437697125640
flankIS/Tn--418911..419891980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 13005.95 Da        Isoelectric Point: 9.9244

>T104256 WP_000843587.1 NZ_CP028828:417259-417591 [Vibrio cholerae]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS

Download         Length: 333 bp

>T104256 NZ_CP028828:417259-417591 [Vibrio cholerae]
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAATATCTCAGTGATGAGGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAACCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTTGCGA
GTAAAGGCAAGGGAAAGCGTGGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGGCGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCTGACTTGAATGCAAATCAAAGGAAACAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11696.20 Da        Isoelectric Point: 6.7600

>AT104256 WP_000071008.1 NZ_CP028828:417578-417892 [Vibrio cholerae]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL

Download         Length: 315 bp

>AT104256 NZ_CP028828:417578-417892 [Vibrio cholerae]
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAGCAGCATTCAGAAGGTAAGCTTACTCT
GAAAACACATCATGTGAATGATGTGGGTGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTCAATA
TGTCCCGCGGAGTCTTCGCGCGGTTACTTCATACGTCTTCGCGCACATTAGAAAACTGGGAACAAGGTCGTAGTGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCCGAGCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB5JA9
PDB8A0X
PDB5MJE
PDB5JA8
PDB5JAA

Antitoxin

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Source
ID
Structure
No matching records found

References