Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 936034..936649 Replicon chromosome
Accession NZ_CP040173
Organism Vibrio cholerae strain VC1374

Toxin (Protein)


Gene name higB Uniprot ID Q9KMG5
Locus tag FDZ90_RS18990 Protein ID WP_001162670.1
Coordinates 936034..936321 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FDZ90_RS18995 Protein ID WP_001232701.1
Coordinates 936332..936649 (+) Length 106 a.a.

Genomic Context

FDZ90_RS18950FDZ90_RS18965FDZ90_RS18970FDZ90_RS18975FDZ90_RS18980FDZ90_RS18985FDZ90_RS18990FDZ90_RS18995FDZ90_RS19000FDZ90_RS19005FDZ90_RS19010FDZ90_RS19015FDZ90_RS19020FDZ90_RS19025FDZ90_RS19030FDZ90_RS19035FDZ90_RS19040FDZ90_RS18955FDZ90_RS18960
Location: 931670..931765 (96 bp)
Type: Others
Protein ID: WP_001907607.1
Location: 932779..933288 (510 bp)
Type: Others
Protein ID: WP_000405987.1
Location: 933345..933998 (654 bp)
Type: Others
Protein ID: WP_000226874.1
Location: 934308..934526 (219 bp)
Type: Others
Protein ID: WP_001917086.1
Location: 934929..935162 (234 bp)
Type: Others
Protein ID: WP_032482776.1
Location: 935587..935767 (181 bp)
Type: Others
Protein ID: Protein_850
Location: 936034..936321 (288 bp)
Type: Toxin
Protein ID: WP_001162670.1
Location: 936332..936649 (318 bp)
Type: Antitoxin
Protein ID: WP_001232701.1
Location: 936646..936756 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 936933..937058 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 937074..937112 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 937325..938329 (1005 bp)
Type: Others
Protein ID: WP_000964925.1
Location: 938482..938928 (447 bp)
Type: Others
Protein ID: WP_000128977.1
Location: 939048..939977 (930 bp)
Type: Others
Protein ID: WP_000335802.1
Location: 939974..940084 (111 bp)
Type: Others
Protein ID: WP_071917832.1
Location: 940112..940588 (477 bp)
Type: Others
Protein ID: WP_001047180.1
Location: 940725..941240 (516 bp)
Type: Others
Protein ID: WP_001201528.1
Location: 931959..932276 (318 bp)
Type: Others
Protein ID: WP_001180243.1
Location: 932295..932537 (243 bp)
Type: Others
Protein ID: WP_000557292.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FDZ90_RS18950931670..931765+96WP_001907607.1DUF645 family protein-
FDZ90_RS18955931959..932276-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxin-
FDZ90_RS18960932295..932537-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
FDZ90_RS18965932779..933288+510WP_000405987.1GNAT family N-acetyltransferase-
FDZ90_RS18970933345..933998+654WP_000226874.1hypothetical protein-
FDZ90_RS18975934308..934526+219WP_001917086.1DUF3709 domain-containing protein-
FDZ90_RS18980934929..935162+234WP_032482776.1DUF3709 domain-containing protein-
FDZ90_RS18985935587..935767+181Protein_850DUF645 family protein-
FDZ90_RS18990936034..936321+288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxinToxin
FDZ90_RS18995936332..936649+318WP_001232701.1HigA family addiction module antidote proteinAntitoxin
FDZ90_RS19000936646..936756+111WP_134814058.1DUF3265 domain-containing protein-
FDZ90_RS19005936933..937058+126WP_001944767.1DUF645 family protein-
FDZ90_RS19010937074..937112+39WP_106019119.1hypothetical protein-
FDZ90_RS19015937325..938329+1005WP_000964925.1LD-carboxypeptidase-
FDZ90_RS19020938482..938928+447WP_000128977.1hypothetical protein-
FDZ90_RS19025939048..939977+930WP_000335802.1hypothetical protein-
FDZ90_RS19030939974..940084+111WP_071917832.1DUF3265 domain-containing protein-
FDZ90_RS19035940112..940588+477WP_001047180.1GNAT family N-acetyltransferase-
FDZ90_RS19040940725..941240+516WP_001201528.1lipocalin family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-882589..97784095251
insideIntegroncatB9-887669..97746489795


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-69)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11349.95 Da        Isoelectric Point: 6.7187

>T125042 WP_001162670.1 NZ_CP040173:936034-936321 [Vibrio cholerae]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY

Download         Length: 288 bp

>T125042 NZ_CP040173:936034-936321 [Vibrio cholerae]
ATGGCATTAGAATTTAAAGATAAGTGGTTAGAGCAGTTTTACGAGGATGATAAACGACATCGTTTAATTCCAAGTAGCAT
AGAGAATGCTCTATTTCGGAAGCTGGAAATCTTAGATGCAGCTCAAGCTGAATCAGACTTAAGAATTCCACCGGGTAATC
GTTTTGAACATCTTGAAGGAAATCTTAAAGGTTGGTGTTCAATTCGAGTGAACAAACAGTATCGTTTGATTTTTCAGTGG
GTTGATGGTGTTGCACTAAATACTTACTTAGACCCACATAAGTATTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11705.63 Da        Isoelectric Point: 10.4711

>AT125042 WP_001232701.1 NZ_CP040173:936332-936649 [Vibrio cholerae]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART

Download         Length: 318 bp

>AT125042 NZ_CP040173:936332-936649 [Vibrio cholerae]
ATGCGTAAGACAAAACGTCGTCCAGTTAGCGTTGGGGAAATGTTAAAAGTTGAATTTCTTGAACCAATGGGCATCACATC
AAAAGCGCTCGCTGAAGCGATGGGCGTACACAGAAATACGGTCAGTAATTTAATTAATGGTGGTGTGTTAACAGCTCCGG
TAGCAATCAAGTTAGCCGCGGCATTAGGTAACACACCAGAATTTTGGCTTAACATTCAACATGCAGTTGATCTTTGGGAT
ACGAGAAATCGTTATCAAGAAGAAGCAAAGTTTGTAAAGCCGTTGTTTGTTTCGCTGGAACAAAGCGCACGTACATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0F2HI36

Antitoxin

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Source
ID
Structure
No matching records found

References