Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 424882..425837 Replicon chromosome
Accession NZ_CP028895
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name - Uniprot ID Q9KM94
Locus tag A1552VC_RS16840 Protein ID WP_000118351.1
Coordinates 425304..425837 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag A1552VC_RS16835 Protein ID WP_001882332.1
Coordinates 424882..425307 (+) Length 142 a.a.

Genomic Context

A1552VC_RS16785A1552VC_RS16790A1552VC_RS16795A1552VC_RS16800A1552VC_RS16820A1552VC_RS16825A1552VC_RS16830A1552VC_RS16835A1552VC_RS16840A1552VC_RS16850A1552VC_RS16855A1552VC_RS16860A1552VC_RS16865A1552VC_RS16870A1552VC_RS16875A1552VC_RS16880A1552VC_RS16885A1552VC_RS16810A1552VC_RS16815
Location: 420412..420663 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 420653..420940 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 421068..421523 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 421845..421997 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 423196..423864 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 424016..424303 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 424444..424815 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 424882..425307 (426 bp)
Type: Antitoxin
Protein ID: WP_001882332.1
Location: 425304..425837 (534 bp)
Type: Toxin
Protein ID: WP_000118351.1
Location: 426039..426296 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 426284..426586 (303 bp)
Type: Others
Protein ID: WP_000229317.1
Location: 426820..427737 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 427894..428283 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 428419..428628 (210 bp)
Type: Others
Protein ID: Protein_465
Location: 428747..429184 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 429248..429466 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 429641..430513 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 422199..422696 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 422693..422965 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
A1552VC_RS16785420412..420663+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
A1552VC_RS16790420653..420940+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
A1552VC_RS16795421068..421523+456WP_001245327.1GNAT family N-acetyltransferase-
A1552VC_RS16800421845..421997+153WP_001884520.1DUF645 family protein-
A1552VC_RS16810422199..422696-498WP_000982260.1GNAT family N-acetyltransferase-
A1552VC_RS16815422693..422965-273WP_000246253.1DUF1778 domain-containing protein-
A1552VC_RS16820423196..423864+669WP_000043871.1hypothetical protein-
A1552VC_RS16825424016..424303+288WP_000426470.1hypothetical protein-
A1552VC_RS16830424444..424815+372WP_001164080.1nucleotide pyrophosphohydrolase-
A1552VC_RS16835424882..425307+426WP_001882332.1DUF1778 domain-containing proteinAntitoxin
A1552VC_RS16840425304..425837+534WP_000118351.1GNAT family N-acetyltransferaseToxin
A1552VC_RS16850426039..426296+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
A1552VC_RS16855426284..426586+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxin-
A1552VC_RS16860426820..427737+918WP_000186333.1alpha/beta hydrolase-
A1552VC_RS16865427894..428283+390WP_001081302.1hypothetical protein-
A1552VC_RS16870428419..428628+210Protein_465GNAT family N-acetyltransferase-
A1552VC_RS16875428747..429184+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
A1552VC_RS16880429248..429466+219WP_071908318.1GNAT family N-acetyltransferase-
A1552VC_RS16885429641..430513+873WP_000254716.1DUF3800 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-306914..436175129261
insideIntegron--311994..435799123805
flankIS/Tn--428747..429184437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(97-153)

Antitoxin

Vibrio phage ICP1, Orf50

(57-133)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 20171.46 Da        Isoelectric Point: 9.1432

>T104348 WP_000118351.1 NZ_CP028895:425304-425837 [Vibrio cholerae]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ

Download         Length: 534 bp

>T104348 NZ_CP028895:425304-425837 [Vibrio cholerae]
GTGAGTTGGGGCAAAGAGTTTGTAGAACTTAGTAAATCAAAGCATGACCGCGACTCATTTGACTGTGGTGAGCAAGAGCT
AAACACATTTATCAAAACTCAAGCTGCAAAGCACATGCAAGCAGGTATTAGCCGAACAATGGTTTTACCTAGTGCTCACC
CACTGTTAAATCAAAAATTCGCTATTTGTGCCTTTTATAGTGTTGCACCGAGCTCAATCAGCCGAGAAACATTACCGGCA
CAATTAGCAAAGAAACTACCGAGGTATCCAATCCCTGTTTTTCTGTTGGCTCAGTTAGCTGTGCACAAAGAATTTCACGG
TTCTGGACTTGGAAAGGTCAGTCTAATCCGTGCGCTGAAGTACTTGTGGGAAGTGAATCATCACATGAGAGCATACGCAA
TAGTTGTGGATTGTCTGACAGATTCCGCTCAAGCGTTCTATACGAAGTTCGGCTTTGAAGTATTGTGCGAACATAATGAG
CGTATTCGTATGTTCTTACCGATGAAAACGGTAGAACAACTTTTTAATCAATAG

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15714.41 Da        Isoelectric Point: 7.6659

>AT104348 WP_001882332.1 NZ_CP028895:424882-425307 [Vibrio cholerae]
MLCLSLVVMRCQPLRRALYSPSPRKLSVRIECALSLAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLGLK
SLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAVKFTEKSGIK

Download         Length: 426 bp

>AT104348 NZ_CP028895:424882-425307 [Vibrio cholerae]
TTGTTGTGTTTGAGTTTAGTGGTCATGCGTTGTCAGCCCCTTAGACGGGCGTTATATTCTCCCTCGCCCCGTAAACTTTC
CGTACGAATTGAATGTGCTTTAAGTTTGGCCTATAATCGCTCAACTGACGGAATGTATCCGTACGCAGGAGGGGTTATGG
CAACGGCACGTTTAGATATCCGCCTTGATGAAGAGATCAAGGCAAAAGCTGAAAAGGCATCGGCTTTACTTGGTTTAAAA
AGTCTCACTGAATATGTGGTGAGACTTATGGACGAAGATGCGACTCATGTTATTGAGGAGCATGAAAGTATTATGGTTAA
AGACAGTGTTTTTGACGAGTTTATGGCTGCGTGTAATAAAGTAAAAGCACCGAATCAAGCTTTGCTTGAAGCTGTTAAAT
TTACAGAGAAGAGCGGTATCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9KM94

Antitoxin

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Source
ID
Structure
No matching records found

References