211921

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 1017262..1018028 Replicon chromosome
Accession NZ_CP080466
Organism Vibrio cholerae strain ICDC-VC3741

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag K1T75_RS18520 Protein ID WP_000982260.1
Coordinates 1017531..1018028 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag K1T75_RS18515 Protein ID WP_000246253.1
Coordinates 1017262..1017534 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K1T75_RS18460 1012759..1013001 - 243 WP_000107461.1 hypothetical protein -
K1T75_RS18985 1013093..1013242 - 150 WP_071908333.1 DUF3265 domain-containing protein -
K1T75_RS18465 1013215..1013466 - 252 WP_001890111.1 TIGR03643 family protein -
K1T75_RS18470 1013661..1014047 - 387 WP_000703163.1 VOC family protein -
K1T75_RS18475 1014037..1014138 - 102 WP_001921603.1 hypothetical protein -
K1T75_RS18990 1014338..1014436 - 99 WP_223225486.1 DUF3709 domain-containing protein -
K1T75_RS18485 1014796..1015074 - 279 WP_001921601.1 DUF3709 domain-containing protein -
K1T75_RS18995 1015192..1015309 - 118 Protein_963 DUF3265 domain-containing protein -
K1T75_RS18490 1015360..1015638 + 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
K1T75_RS18495 1015631..1015900 + 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin -
K1T75_RS18500 1016048..1016494 - 447 WP_000006157.1 hypothetical protein -
K1T75_RS18510 1016744..1016869 - 126 WP_001900195.1 DUF645 family protein -
K1T75_RS18515 1017262..1017534 + 273 WP_000246253.1 DUF1778 domain-containing protein Antitoxin
K1T75_RS18520 1017531..1018028 + 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
K1T75_RS19000 1018045..1018113 - 69 Protein_970 acetyltransferase -
K1T75_RS18525 1018178..1018639 - 462 WP_001903091.1 lipocalin family protein -
K1T75_RS18530 1018830..1019366 - 537 WP_000469482.1 GNAT family protein -
K1T75_RS18535 1019624..1019845 - 222 WP_032467793.1 DUF1289 domain-containing protein -
K1T75_RS18540 1019854..1019967 - 114 WP_001900214.1 hypothetical protein -
K1T75_RS18545 1020024..1020410 - 387 WP_001015867.1 NUDIX hydrolase -
K1T75_RS18550 1020654..1020896 + 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
K1T75_RS18555 1020915..1021232 + 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin -
K1T75_RS18560 1021386..1021724 - 339 WP_000713853.1 hypothetical protein -
K1T75_RS18565 1021882..1022586 - 705 WP_000087610.1 HNH endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 932680..1039634 106954
inside Integron - - 933056..1032792 99736


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T211921 WP_000982260.1 NZ_CP080466:1017531-1018028 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T211921 NZ_CP106849:1964184-1964441 [Edwardsiella ictaluri]
ATGCCAGAGATTGATGCCCTGATGGGGCTAAGCTTTGTGATGTATTTCTTCGACAATCAAACTCACAGTTTGCCGCATGT
CCATGTGAAATACGGCGAATTTGAGCTGGTTATCGGGATCGACTCAGGAGAGGCCTTGGAGGGTTACCTTCCCCCTAAAA
AGAGGAAACTGGCCGAGTCACATATCAAGGCCAATAAAACCAGGCTACTGGCTATGTGGCAGATGGCGGTTAATGGGATG
CATCCTGGGAAACTGTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT211921 WP_000246253.1 NZ_CP080466:1017262-1017534 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT211921 NZ_CP106849:1964451-1964963 [Edwardsiella ictaluri]
ATGTTGAAAATTATTGATGTGGATGTGGTCGGCGACCATGTTATCGAGGTCGAATTTAGCGACGGCTTCCGTGGTAGGGC
TGATTTAGCCGCGCTGTTCAGCAAACCGCCCTTCTCTGCGATCGCCGACTTTAACCGCTTTTCCCTGACAGCCAGCGGCG
TGCTGAACTGGGGAGATGCCGAGCTTTCTGCCGATACGGTTAGGCGCATCAGCAAAGGCGCAGTGGTATCGGCATCCTCA
CGCGCACTCACGCCAGAAAATGTAGAAGCGATCCTCCGCCAGGCCACCTGGGAATCCATGAGCGAGGGGCGCCCGGATAT
TTTGCAGGCCGCGTTAAGGGGATACGCGGAGCAGCTGGGCCACGCGGACGTCATCAAGAGGGCCGGGATTGCCAGCCGCA
GCAGTGCATACAAAACGCTATCGCCATCAACGAACCCCAGCTTTAAATCGCTGGCAAAGATCAGCGGCGCGATTTTGGCT
ATCGTGCGTGAAAATAACGCGCAGCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2IC79

References