Detailed information of TA system TA125051

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DhiAT/-
• Location: 973119..973903
• Replicon: chromosome
• Accession: NZ_CP040173
• Organism: Vibrio cholerae strain VC1374

Toxin (Protein)

• Gene name: dhiT
• Uniprot ID: A0A086SLD6
• Locus tag: FDZ90_RS19335
• Protein ID: WP_001114075.1
• Coordinates: 973119..973388 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: dhiA
• Uniprot ID: Q9KM84
• Locus tag: FDZ90_RS19340
• Protein ID: WP_000921691.1
• Coordinates: 973382..973903 (+)
• Length: 174 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FDZ90_RS19295	968486..969403	+	918	WP_000186333.1	alpha/beta hydrolase	-
FDZ90_RS19300	969560..969949	+	390	WP_001081302.1	hypothetical protein	-
FDZ90_RS19305	970085..970294	+	210	Protein_914	GNAT family N-acetyltransferase	-
FDZ90_RS19310	970413..970850	+	438	WP_000503169.1	IS200/IS605-like element IS1004 family transposase	-
FDZ90_RS19315	970913..971131	+	219	WP_071908318.1	GNAT family N-acetyltransferase	-
FDZ90_RS19320	971306..972178	+	873	WP_000254716.1	DUF3800 domain-containing protein	-
FDZ90_RS19325	972328..972927	+	600	WP_001891245.1	glutathione S-transferase N-terminal domain-containing protein	-
FDZ90_RS19330	972984..973088	+	105	WP_099607150.1	acetyltransferase	-
FDZ90_RS19335	973119..973388	+	270	WP_001114075.1	DUF4160 domain-containing protein	Toxin
FDZ90_RS19340	973382..973903	+	522	WP_000921691.1	DUF2442 domain-containing protein	Antitoxin
FDZ90_RS19345	974202..974327	+	126	WP_001905700.1	DUF645 family protein	-
FDZ90_RS19350	974578..974973	+	396	WP_001000867.1	hypothetical protein	-
FDZ90_RS19355	975112..975390	-	279	WP_000578476.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	-
FDZ90_RS19360	975387..975671	-	285	WP_000381183.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
FDZ90_RS19365	975865..976380	+	516	WP_000343779.1	GNAT family N-acetyltransferase	-
FDZ90_RS19370	976564..976977	+	414	WP_000049420.1	VOC family protein	-
FDZ90_RS19375	977532..978709	+	1178	WP_086010879.1	IS3-like element ISVch4 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	catB9	-	882589..977840	95251
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 Integron TA000164, TA000169, TA000166, TA000167, TA000179, TA000170, TA000171, TA000172, TA000173, TA000174, TA000175, TA000176, TA000177, TA000178, TA000168, TA000165, TA010030, TA010035 309750..435387 0.005	inside	Integron	catB9	-	887669..977464	89795
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 IS/Tn TA000179, TA000177, TA000178, TA010035 428335..428772 0	flank	IS/Tn	-	-	970413..970850	437

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF4160 (9-74)

Antitoxin

• Protein of unknown function DUF2442 (4-59)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10310.94 Da
• Isoelectric Point: 6.6303

>T125051 WP_001114075.1 NZ_CP040173:973119-973388 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Nucleotide

• Length: 270 bp

>T125051 NZ_CP040173:973119-973388 [Vibrio cholerae]
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin

Protein

• Length: 174 a.a.
• Molecular weight: 19409.01 Da
• Isoelectric Point: 6.7342

>AT125051 WP_000921691.1 NZ_CP040173:973382-973903 [Vibrio cholerae]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKAPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Nucleotide

• Length: 522 bp

>AT125051 NZ_CP040173:973382-973903 [Vibrio cholerae]
ATGTTGAAAGTCATAGATGTTGATTTTGTCTCAGACCATACATTAGAACTGACGTTCAATGATGGTTACCAAGGCTATGC
CGACTTGTCGGTATACTTTAAAAAAGCACCGTTTTCAGAAATTAAGGACTTTAAACGCTTTTCCTTGACTCGTGATGGCT
CGTTAAATTGGGATGGTAATGAGTTAACGGCCGCGACACTCCGTGACATAACCAAGGGCTCACAAAAGTCGGTGGAGTTA
AGTTTTAATGTTCAAGAAATGGAAGCCGTCATCAAACAGGCCTCATGGGAATCGATGATGGAGGGGCGTCCCGACATCTT
GCAAGCGGCTATTCGTTCTTACGTAGAGCAGTTTGGTCATGGTCAAGTTATTGCAAAGGCGGGTATAAAAAGTCGTACGA
GTGCTTATCGCTCCTTGAAGCCAGAAACAACGCCAAACTTTGGCACACTAGTTCAGTTAGGGCACGCCGTCATCGAACTA
GCGAAAGATAGAACAGTGGCAAACAAGGAACCACGCATATAA

Structures

Toxin

• AlphaFold DB: A0A086SLD6

Antitoxin

• AlphaFold DB: Q9KM84