Detailed information of TA system TA038632

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 111296..111855
• Replicon: chromosome
• Accession: NZ_AP024548
• Organism: Vibrio cholerae strain BCH-01536

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q9K2M8
• Locus tag: K6J77_RS14775
• Protein ID: WP_000578476.1
• Coordinates: 111296..111574 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q9L991
• Locus tag: K6J77_RS14780
• Protein ID: WP_000381183.1
• Coordinates: 111571..111855 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K6J77_RS14730	106596..107033	+	438	WP_000503169.1	IS200/IS605-like element IS1004 family transposase	-
K6J77_RS14735	107094..107315	+	222	Protein_206	GNAT family N-acetyltransferase	-
K6J77_RS14740	107490..108362	+	873	WP_000254716.1	DUF3800 domain-containing protein	-
K6J77_RS14745	108512..109111	+	600	WP_001891245.1	glutathione S-transferase N-terminal domain-containing protein	-
K6J77_RS14750	109168..109236	+	69	Protein_209	acetyltransferase	-
K6J77_RS14755	109303..109572	+	270	WP_001114075.1	DUF4160 domain-containing protein	-
K6J77_RS14760	109566..110087	+	522	WP_000921691.1	DUF2442 domain-containing protein	-
K6J77_RS14765	110386..110511	+	126	WP_001905700.1	DUF645 family protein	-
K6J77_RS14770	110762..111157	+	396	WP_001000867.1	hypothetical protein	-
K6J77_RS14775	111296..111574	-	279	WP_000578476.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
K6J77_RS14780	111571..111855	-	285	WP_000381183.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
K6J77_RS14785	112049..112564	+	516	WP_000343779.1	GNAT family protein	-
K6J77_RS14790	112748..113161	+	414	WP_000049420.1	VOC family protein	-
K6J77_RS14795	113716..114892	+	1177	WP_086014537.1	IS3-like element ISVch4 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 Integron TA000164, TA000169, TA000166, TA000167, TA000179, TA000170, TA000171, TA000172, TA000173, TA000174, TA000175, TA000176, TA000177, TA000178, TA000168, TA000165, TA010030, TA010035 309750..435387 0.004	inside	Integron	-	-	11978..113648	101670
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 IS/Tn TA000179, TA000177, TA000178, TA010035 428335..428772 0	flank	IS/Tn	-	-	106596..107033	437

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-70)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10819.59 Da
• Isoelectric Point: 5.1651

>T38632 WP_000578476.1 NZ_AP024548:c111574-111296 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Nucleotide

• Length: 279 bp

>T38632 NZ_AP024548:c111574-111296 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10901.25 Da
• Isoelectric Point: 8.0775

>AT38632 WP_000381183.1 NZ_AP024548:c111855-111571 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Nucleotide

• Length: 285 bp

>AT38632 NZ_AP024548:c111855-111571 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Structures

Toxin

• AlphaFold DB: Q9K2M8

Antitoxin

• AlphaFold DB: A0A067BL33