294414

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 272218..272851 Replicon chromosome
Accession NZ_LT992493
Organism Vibrio cholerae strain 4295STDY6534248

Toxin (Protein)


Gene name higB Uniprot ID Q9KMA6
Locus tag DG169_RS16045 Protein ID WP_000843587.1
Coordinates 272218..272550 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DG169_RS16050 Protein ID WP_000071008.1
Coordinates 272537..272851 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DG169_RS19760 267659..267862 + 204 WP_001911745.1 hypothetical protein -
DG169_RS15975 268143..268316 + 174 WP_001882305.1 DUF3709 domain-containing protein -
DG169_RS15980 268676..268945 + 270 WP_001198131.1 hypothetical protein -
DG169_RS19900 269263..269434 + 172 Protein_292 DUF645 family protein -
DG169_RS15995 269643..270029 + 387 WP_000703163.1 VOC family protein -
DG169_RS16000 270231..270473 + 243 WP_000107461.1 hypothetical protein -
DG169_RS16005 270644..271021 + 378 WP_000411109.1 hypothetical protein -
DG169_RS19860 271078..271192 + 115 Protein_296 acetyltransferase -
DG169_RS16010 271141..271422 + 282 WP_001894453.1 DUF1289 domain-containing protein -
DG169_RS16025 271588..271701 + 114 WP_001889158.1 hypothetical protein -
DG169_RS16030 271650..271877 + 228 WP_001894457.1 DUF1289 domain-containing protein -
DG169_RS16045 272218..272550 + 333 WP_000843587.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DG169_RS16050 272537..272851 + 315 WP_000071008.1 DNA-binding transcriptional regulator Antitoxin
DG169_RS16055 272988..273422 + 435 WP_000256036.1 GNAT family N-acetyltransferase -
DG169_RS19685 273590..273745 + 156 WP_000751734.1 hypothetical protein -
DG169_RS16060 273870..274850 - 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
DG169_RS16065 274918..275224 + 307 Protein_305 CatB-related O-acetyltransferase -
DG169_RS16070 275361..276053 + 693 WP_001047169.1 GNAT family N-acetyltransferase -
DG169_RS16075 276053..276454 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
DG169_RS16080 276424..276567 + 144 WP_071908341.1 DUF3265 domain-containing protein -
DG169_RS16085 276642..277055 + 414 WP_000049417.1 VOC family protein -
DG169_RS16090 277269..277520 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
DG169_RS16095 277510..277797 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 197768..293032 95264
inside Integron catB9 - 202848..292656 89808
flank IS/Tn - - 273870..274850 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 13005.95 Da        Isoelectric Point: 9.9244

>T294414 WP_000843587.1 NZ_LT992493:272218-272550 [Vibrio cholerae]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS

Download         Length: 333 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11696.20 Da        Isoelectric Point: 6.7600

>AT294414 WP_000071008.1 NZ_LT992493:272537-272851 [Vibrio cholerae]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5JA9
PDB 8A0X
PDB 5MJE
PDB 5JA8
PDB 5JAA

Antitoxin

Source ID Structure

References