58265

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 361585..362125 Replicon chromosome
Accession NZ_CP013306
Organism Vibrio cholerae strain CRC1106

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag ASZ81_RS16085 Protein ID WP_000277238.1
Coordinates 361585..361854 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag ASZ81_RS16090 Protein ID WP_001258569.1
Coordinates 361847..362125 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ81_RS16030 356589..356831 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
ASZ81_RS16035 357075..357461 + 387 WP_001015867.1 NUDIX hydrolase -
ASZ81_RS16040 357518..357631 + 114 WP_001900214.1 hypothetical protein -
ASZ81_RS16045 357580..357861 + 282 WP_001894429.1 DUF1289 domain-containing protein -
ASZ81_RS16055 358119..358655 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
ASZ81_RS16060 358792..359307 + 516 WP_001201509.1 lipocalin family protein -
ASZ81_RS16065 359457..359954 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
ASZ81_RS16070 359951..360223 - 273 WP_000246254.1 DUF1778 domain-containing protein -
ASZ81_RS20490 360616..360741 + 126 WP_001900195.1 DUF645 family protein -
ASZ81_RS20495 360757..360795 + 39 WP_106019118.1 hypothetical protein -
ASZ81_RS16080 360991..361437 + 447 WP_000006157.1 hypothetical protein -
ASZ81_RS16085 361585..361854 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin Toxin
ASZ81_RS16090 361847..362125 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
ASZ81_RS16095 362411..362689 + 279 WP_001921601.1 DUF3709 domain-containing protein -
ASZ81_RS20510 362941..363147 + 207 Protein_347 DUF3709 domain-containing protein -
ASZ81_RS20515 363347..363448 + 102 WP_001921603.1 hypothetical protein -
ASZ81_RS16100 363438..363824 + 387 WP_000703163.1 VOC family protein -
ASZ81_RS16105 364019..364270 + 252 WP_001890111.1 TIGR03643 family protein -
ASZ81_RS16110 364243..364392 + 150 WP_071908333.1 DUF3265 domain-containing protein -
ASZ81_RS16115 364484..364726 + 243 WP_000107461.1 hypothetical protein -
ASZ81_RS16120 364978..365256 + 279 WP_000280324.1 DUF3709 domain-containing protein -
ASZ81_RS20920 365631..365774 + 144 Protein_354 DUF645 family protein -
ASZ81_RS20925 365828..365866 + 39 WP_082798268.1 hypothetical protein -
ASZ81_RS16135 366078..366545 + 468 WP_001289288.1 OsmC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304741..463550 158809
inside Integron - - 309821..463174 153353


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T58265 WP_000277238.1 NZ_CP013306:c361854-361585 [Vibrio cholerae]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T58265 NZ_CP013306:c361854-361585 [Vibrio cholerae]
ATGTATAAACTCGAATACTCCACACAGTTTAAGAAAGATTTCAAAAAGATAACTAAGATGCCGATTTCAGACATCATTGA
AGTCGGCAATGTTATTTCTAAGCTGCAACGCGGCGAAAAGCTTGAACCCAAGAATGTTGACCATCCGTTAACTGGAAATT
GGGTTGGATTTCGAGACTGCCACATTAAACCCGACCTAGTGTTAATCTATCGAGTTTTTAACGATCAACTACAACTAGCG
CGCATTGGTTCACATAGTGATTTATTCTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT58265 WP_001258569.1 NZ_CP013306:c362125-361847 [Vibrio cholerae]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp

>AT58265 NZ_CP013306:c362125-361847 [Vibrio cholerae]
ATGAGAACAGAAATGCTGAGCACGCGCATTGACCACGACACGAAAATTGCGTTCACAAACGTCTGCGATGAGATGGGTCT
AAGTACATCACAGGCCATAAAGTTATTTGCAAAAGCGGTTATTAATCATGGTGGAATCCCTTTTGAGCTGCGAGTTCCAC
AGCCTAATGAGGTTACTGCATCTGCAATTCAAGAGCTCGTTGAAGGAAAAGGACATAAAGCTGAATCCGTTGAAGCTATG
CTGAATGAGCTTACTGAAGGCAAAGTTAAGCATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A151JGK8

Antitoxin

Source ID Structure
AlphaFold DB A0A151KTP9

References