Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 423192..423739 Replicon chromosome
Accession NZ_CP025937
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag C1H56_RS16815 Protein ID WP_000229317.1
Coordinates 423437..423739 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag C1H56_RS16810 Protein ID WP_000861987.1
Coordinates 423192..423449 (+) Length 86 a.a.

Genomic Context

C1H56_RS16755C1H56_RS16760C1H56_RS16780C1H56_RS16785C1H56_RS16790C1H56_RS20010C1H56_RS16800C1H56_RS16810C1H56_RS16815C1H56_RS16820C1H56_RS16825C1H56_RS16830C1H56_RS16835C1H56_RS16840C1H56_RS16845C1H56_RS16850C1H56_RS16855C1H56_RS16770C1H56_RS16775
Location: 418221..418676 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 418998..419150 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 420349..421017 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 421169..421456 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 421597..421968 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 422035..422460 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 422457..422990 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 423192..423449 (258 bp)
Type: Antitoxin
Protein ID: WP_000861987.1
Location: 423437..423739 (303 bp)
Type: Toxin
Protein ID: WP_000229317.1
Location: 423973..424890 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 425047..425436 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 425572..425781 (210 bp)
Type: Others
Protein ID: Protein_464
Location: 425900..426337 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 426401..426619 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 426794..427666 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 427816..428415 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 428472..428576 (105 bp)
Type: Others
Protein ID: WP_099607150.1
Location: 419352..419849 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 419846..420118 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
C1H56_RS16755418221..418676+456WP_001245327.1GNAT family N-acetyltransferase-
C1H56_RS16760418998..419150+153WP_001884520.1DUF645 family protein-
C1H56_RS16770419352..419849-498WP_000982260.1GNAT family N-acetyltransferase-
C1H56_RS16775419846..420118-273WP_000246253.1DUF1778 domain-containing protein-
C1H56_RS16780420349..421017+669WP_000043871.1hypothetical protein-
C1H56_RS16785421169..421456+288WP_000426470.1hypothetical protein-
C1H56_RS16790421597..421968+372WP_001164080.1nucleotide pyrophosphohydrolase-
C1H56_RS20010422035..422460+426WP_001882332.1DUF1778 domain-containing protein-
C1H56_RS16800422457..422990+534WP_000118351.1GNAT family N-acetyltransferase-
C1H56_RS16810423192..423449+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
C1H56_RS16815423437..423739+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxinToxin
C1H56_RS16820423973..424890+918WP_000186333.1alpha/beta hydrolase-
C1H56_RS16825425047..425436+390WP_001081302.1hypothetical protein-
C1H56_RS16830425572..425781+210Protein_464GNAT family N-acetyltransferase-
C1H56_RS16835425900..426337+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
C1H56_RS16840426401..426619+219WP_071908318.1GNAT family N-acetyltransferase-
C1H56_RS16845426794..427666+873WP_000254716.1DUF3800 domain-containing protein-
C1H56_RS16850427816..428415+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
C1H56_RS16855428472..428576+105WP_099607150.1acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304067..433328129261
insideIntegroncatB9-309147..432952123805
flankIS/Tn--425900..426337437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T92516 WP_000229317.1 NZ_CP025937:423437-423739 [Vibrio cholerae]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T92516 NZ_CP025937:423437-423739 [Vibrio cholerae]
ATGGTTGAAATAATTTGGACGGAGCTGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAGTCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT92516 WP_000861987.1 NZ_CP025937:423192-423449 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT92516 NZ_CP025937:423192-423449 [Vibrio cholerae]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9KM92

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1T4SLM9

References