Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/ParE-Phd |
Location | 423192..423739 | Replicon | chromosome |
Accession | NZ_CP025937 | ||
Organism | Vibrio cholerae strain A1552 |
Toxin (Protein)
Gene name | relE | Uniprot ID | Q9KM92 |
Locus tag | C1H56_RS16815 | Protein ID | WP_000229317.1 |
Coordinates | 423437..423739 (+) | Length | 101 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | Q9KM93 |
Locus tag | C1H56_RS16810 | Protein ID | WP_000861987.1 |
Coordinates | 423192..423449 (+) | Length | 86 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
C1H56_RS16755 | 418221..418676 | + | 456 | WP_001245327.1 | GNAT family N-acetyltransferase | - |
C1H56_RS16760 | 418998..419150 | + | 153 | WP_001884520.1 | DUF645 family protein | - |
C1H56_RS16770 | 419352..419849 | - | 498 | WP_000982260.1 | GNAT family N-acetyltransferase | - |
C1H56_RS16775 | 419846..420118 | - | 273 | WP_000246253.1 | DUF1778 domain-containing protein | - |
C1H56_RS16780 | 420349..421017 | + | 669 | WP_000043871.1 | hypothetical protein | - |
C1H56_RS16785 | 421169..421456 | + | 288 | WP_000426470.1 | hypothetical protein | - |
C1H56_RS16790 | 421597..421968 | + | 372 | WP_001164080.1 | nucleotide pyrophosphohydrolase | - |
C1H56_RS20010 | 422035..422460 | + | 426 | WP_001882332.1 | DUF1778 domain-containing protein | - |
C1H56_RS16800 | 422457..422990 | + | 534 | WP_000118351.1 | GNAT family N-acetyltransferase | - |
C1H56_RS16810 | 423192..423449 | + | 258 | WP_000861987.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
C1H56_RS16815 | 423437..423739 | + | 303 | WP_000229317.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
C1H56_RS16820 | 423973..424890 | + | 918 | WP_000186333.1 | alpha/beta hydrolase | - |
C1H56_RS16825 | 425047..425436 | + | 390 | WP_001081302.1 | hypothetical protein | - |
C1H56_RS16830 | 425572..425781 | + | 210 | Protein_464 | GNAT family N-acetyltransferase | - |
C1H56_RS16835 | 425900..426337 | + | 438 | WP_000503169.1 | IS200/IS605-like element IS1004 family transposase | - |
C1H56_RS16840 | 426401..426619 | + | 219 | WP_071908318.1 | GNAT family N-acetyltransferase | - |
C1H56_RS16845 | 426794..427666 | + | 873 | WP_000254716.1 | DUF3800 domain-containing protein | - |
C1H56_RS16850 | 427816..428415 | + | 600 | WP_001891245.1 | glutathione S-transferase N-terminal domain-containing protein | - |
C1H56_RS16855 | 428472..428576 | + | 105 | WP_099607150.1 | acetyltransferase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | catB9 | - | 304067..433328 | 129261 | |
inside | Integron | catB9 | - | 309147..432952 | 123805 | ||
flank | IS/Tn | - | - | 425900..426337 | 437 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11726.68 Da Isoelectric Point: 5.1972
>T92516 WP_000229317.1 NZ_CP025937:423437-423739 [Vibrio cholerae]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ
Download Length: 303 bp
>T92516 NZ_CP025937:423437-423739 [Vibrio cholerae]
ATGGTTGAAATAATTTGGACGGAGCTGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAGTCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG
ATGGTTGAAATAATTTGGACGGAGCTGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAGTCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG
Antitoxin
Download Length: 86 a.a. Molecular weight: 9647.15 Da Isoelectric Point: 7.3178
>AT92516 WP_000861987.1 NZ_CP025937:423192-423449 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK
Download Length: 258 bp
>AT92516 NZ_CP025937:423192-423449 [Vibrio cholerae]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | Q9KM92 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1T4SLM9 |