38618

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 30182..30722 Replicon chromosome
Accession NZ_AP024548
Organism Vibrio cholerae strain BCH-01536

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag K6J77_RS14060 Protein ID WP_000277238.1
Coordinates 30182..30451 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag K6J77_RS14065 Protein ID WP_001258569.1
Coordinates 30444..30722 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J77_RS14020 25404..25940 + 537 WP_000469482.1 GNAT family protein -
K6J77_RS14025 26131..26592 + 462 WP_001903091.1 lipocalin family protein -
K6J77_RS18940 26657..26725 + 69 Protein_40 acetyltransferase -
K6J77_RS14030 26742..27238 - 497 Protein_41 GNAT family N-acetyltransferase -
K6J77_RS14035 27235..27507 - 273 WP_000246253.1 DUF1778 domain-containing protein -
K6J77_RS14040 27900..28025 + 126 WP_001900195.1 DUF645 family protein -
K6J77_RS14050 28275..28721 + 447 WP_000006157.1 hypothetical protein -
K6J77_RS14055 28784..29995 + 1212 WP_001122813.1 IS256 family transposase -
K6J77_RS14060 30182..30451 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin Toxin
K6J77_RS14065 30444..30722 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K6J77_RS18945 30773..30890 + 118 Protein_48 DUF3265 domain-containing protein -
K6J77_RS14070 31008..31286 + 279 WP_001921601.1 DUF3709 domain-containing protein -
K6J77_RS18950 31646..31744 + 99 WP_223225486.1 DUF3709 domain-containing protein -
K6J77_RS14080 31944..32045 + 102 WP_001921603.1 hypothetical protein -
K6J77_RS14085 32035..32421 + 387 WP_000703163.1 VOC family protein -
K6J77_RS14090 32616..32867 + 252 WP_001890111.1 TIGR03643 family protein -
K6J77_RS18955 32840..32989 + 150 WP_071908333.1 DUF3265 domain-containing protein -
K6J77_RS14095 33081..33323 + 243 WP_000107461.1 hypothetical protein -
K6J77_RS14100 33575..33853 + 279 WP_000280324.1 DUF3709 domain-containing protein -
K6J77_RS18960 34285..34328 + 44 Protein_57 hypothetical protein -
K6J77_RS18965 34310..34403 + 94 Protein_58 ggdef family protein -
K6J77_RS18970 34372..34503 + 132 WP_001883067.1 hypothetical protein -
K6J77_RS14115 34675..35142 + 468 WP_001289288.1 OsmC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Integron - - 11978..113648 101670
- flank IS/Tn - - 28784..29995 1211


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T38618 WP_000277238.1 NZ_AP024548:c30451-30182 [Vibrio cholerae]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T38618 NZ_AP024548:c30451-30182 [Vibrio cholerae]
ATGTATAAACTCGAATACTCCACACAGTTTAAGAAAGATTTCAAAAAGATAACTAAGATGCCGATTTCAGACATCATTGA
AGTCGGCAATGTTATTTCTAAGCTGCAACGCGGCGAAAAGCTTGAACCCAAGAATGTTGACCATCCGTTAACTGGAAATT
GGGTTGGATTTCGAGACTGCCACATTAAACCCGACCTAGTGTTAATCTATCGAGTTTTTAACGATCAACTACAACTAGCG
CGCATTGGTTCACATAGTGATTTATTCTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT38618 WP_001258569.1 NZ_AP024548:c30722-30444 [Vibrio cholerae]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp

>AT38618 NZ_AP024548:c30722-30444 [Vibrio cholerae]
ATGAGAACAGAAATGCTGAGCACGCGCATTGACCACGACACGAAAATTGCGTTCACAAACGTCTGCGATGAGATGGGTCT
AAGTACATCACAGGCCATAAAGTTATTTGCAAAAGCGGTTATTAATCATGGTGGAATCCCTTTTGAGCTGCGAGTTCCAC
AGCCTAATGAGGTTACTGCATCTGCAATTCAAGAGCTCGTTGAAGGAAAAGGACATAAAGCTGAATCCGTTGAAGCTATG
CTGAATGAGCTTACTGAAGGCAAAGTTAAGCATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A151JGK8

Antitoxin

Source ID Structure
AlphaFold DB A0A151KTP9

References