Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 343239..343798 Replicon chromosome
Accession NZ_LT906615
Organism Vibrio cholerae O1 biovar El Tor str. N16961

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag FY484_RS15595 Protein ID WP_000578476.1
Coordinates 343239..343517 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag FY484_RS15600 Protein ID WP_000381183.1
Coordinates 343514..343798 (-) Length 95 a.a.

Genomic Context

FY484_RS15540FY484_RS15545FY484_RS15550FY484_RS15555FY484_RS15560FY484_RS15565FY484_RS15570FY484_RS15575FY484_RS15585FY484_RS15605FY484_RS15610FY484_RS15620FY484_RS15625FY484_RS15630FY484_RS15635FY484_RS15640FY484_RS15645FY484_RS15595FY484_RS15600
Location: 338317..338823 (507 bp)
Type: Others
Protein ID: WP_000393074.1
Location: 338980..339366 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 339623..339826 (204 bp)
Type: Others
Protein ID: WP_001911580.1
Location: 340021..340272 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 340245..340394 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 340541..340966 (426 bp)
Type: Others
Protein ID: WP_000415750.1
Location: 341172..341795 (624 bp)
Type: Others
Protein ID: WP_000247070.1
Location: 342008..342487 (480 bp)
Type: Others
Protein ID: WP_000009888.1
Location: 342675..343088 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 343993..344508 (516 bp)
Type: Others
Protein ID: WP_001201520.1
Location: 344573..345169 (597 bp)
Type: Others
Protein ID: WP_000255434.1
Location: 345561..345743 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 345943..346416 (474 bp)
Type: Others
Protein ID: WP_001161076.1
Location: 346431..346523 (93 bp)
Type: Others
Protein ID: WP_014378730.1
Location: 346565..347191 (627 bp)
Type: Others
Protein ID: WP_000365424.1
Location: 347314..348012 (699 bp)
Type: Others
Protein ID: WP_001890502.1
Location: 348022..348132 (111 bp)
Type: Others
Protein ID: WP_079857360.1
Location: 343239..343517 (279 bp)
Type: Toxin
Protein ID: WP_000578476.1
Location: 343514..343798 (285 bp)
Type: Antitoxin
Protein ID: WP_000381183.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FY484_RS15540338317..338823+507WP_000393074.1hypothetical protein-
FY484_RS15545338980..339366+387WP_000703163.1VOC family protein-
FY484_RS15550339623..339826+204WP_001911580.1hypothetical protein-
FY484_RS15555340021..340272+252WP_001890111.1TIGR03643 family protein-
FY484_RS15560340245..340394+150WP_071908333.1DUF3265 domain-containing protein-
FY484_RS15565340541..340966+426WP_000415750.1hypothetical protein-
FY484_RS15570341172..341795+624WP_000247070.1DUF1349 domain-containing protein-
FY484_RS15575342008..342487+480WP_000009888.1lecithin retinol acyltransferase family protein-
FY484_RS15585342675..343088+414WP_000049420.1VOC family protein-
FY484_RS15595343239..343517-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
FY484_RS15600343514..343798-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
FY484_RS15605343993..344508+516WP_001201520.1lipocalin family protein-
FY484_RS15610344573..345169+597WP_000255434.1hypothetical protein-
FY484_RS15620345561..345743+183WP_000923182.1DUF645 family protein-
FY484_RS15625345943..346416+474WP_001161076.1GrpB family protein-
FY484_RS15630346431..346523+93WP_014378730.1DUF3265 domain-containing protein-
FY484_RS15635346565..347191+627WP_000365424.1LysE family translocator-
FY484_RS15640347314..348012+699WP_001890502.1hypothetical protein-
FY484_RS15645348022..348132+111WP_079857360.1DUF3265 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304666..435761131095
insideIntegroncatB9-309746..435385125639


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T293796 WP_000578476.1 NZ_LT906615:c343517-343239 [Vibrio cholerae O1 biovar El Tor str. N16961]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT293796 WP_000381183.1 NZ_LT906615:c343798-343514 [Vibrio cholerae O1 biovar El Tor str. N16961]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9K2M8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A067BL33

References