Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 322653..323231 Replicon chromosome II
Accession NC_016945
Organism Vibrio cholerae IEC224

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag O3Y_RS15425 Protein ID WP_001180243.1
Coordinates 322653..322970 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag O3Y_RS15430 Protein ID WP_000557292.1
Coordinates 322989..323231 (-) Length 81 a.a.

Genomic Context

O3Y_RS15390O3Y_RS15400O3Y_RS15405O3Y_RS15410O3Y_RS15415O3Y_RS15420O3Y_RS15435O3Y_RS19615O3Y_RS15440O3Y_RS15450O3Y_RS15455O3Y_RS20140O3Y_RS20145O3Y_RS15475O3Y_RS15425O3Y_RS15430O3Y_RS15460O3Y_RS15465
Location: 318177..318359 (183 bp)
Type: Others
Protein ID: WP_000923340.1
Location: 318713..318895 (183 bp)
Type: Others
Protein ID: WP_000923153.1
Location: 319090..319767 (678 bp)
Type: Others
Protein ID: WP_000254617.1
Location: 319929..321137 (1209 bp)
Type: Others
Protein ID: WP_000272282.1
Location: 321299..322003 (705 bp)
Type: Others
Protein ID: WP_000087610.1
Location: 322161..322499 (339 bp)
Type: Others
Protein ID: WP_000713853.1
Location: 323475..323861 (387 bp)
Type: Others
Protein ID: WP_001015867.1
Location: 323918..324031 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 323980..324261 (282 bp)
Type: Others
Protein ID: WP_001894429.1
Location: 324519..325055 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 325192..325707 (516 bp)
Type: Others
Protein ID: WP_001201510.1
Location: 327016..327141 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 327157..327195 (39 bp)
Type: Others
Protein ID: WP_106019118.1
Location: 327391..327837 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 322653..322970 (318 bp)
Type: Toxin
Protein ID: WP_001180243.1
Location: 322989..323231 (243 bp)
Type: Antitoxin
Protein ID: WP_000557292.1
Location: 325857..326354 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 326351..326623 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
O3Y_RS15390318177..318359+183WP_000923340.1DUF645 family protein-
O3Y_RS15400318713..318895+183WP_000923153.1DUF645 family protein-
O3Y_RS15405319090..319767+678WP_000254617.1HNH endonuclease-
O3Y_RS15410319929..321137+1209WP_000272282.1deoxyguanosinetriphosphate triphosphohydrolase family protein-
O3Y_RS15415321299..322003+705WP_000087610.1HNH endonuclease-
O3Y_RS15420322161..322499+339WP_000713853.1hypothetical protein-
O3Y_RS15425322653..322970-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxinToxin
O3Y_RS15430322989..323231-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
O3Y_RS15435323475..323861+387WP_001015867.1NUDIX hydrolase-
O3Y_RS19615323918..324031+114WP_001900214.1hypothetical protein-
O3Y_RS15440323980..324261+282WP_001894429.1DUF1289 domain-containing protein-
O3Y_RS15450324519..325055+537WP_000469482.1GNAT family N-acetyltransferase-
O3Y_RS15455325192..325707+516WP_001201510.1lipocalin family protein-
O3Y_RS15460325857..326354-498WP_000982260.1GNAT family N-acetyltransferase-
O3Y_RS15465326351..326623-273WP_000246253.1DUF1778 domain-containing protein-
O3Y_RS20140327016..327141+126WP_001900195.1DUF645 family protein-
O3Y_RS20145327157..327195+39WP_106019118.1hypothetical protein-
O3Y_RS15475327391..327837+447WP_000006157.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304637..435582130945
insideIntegron--309717..435206125489


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T26143 WP_001180243.1 NC_016945:c322970-322653 [Vibrio cholerae IEC224]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T26143 NC_016945:c322970-322653 [Vibrio cholerae IEC224]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT26143 WP_000557292.1 NC_016945:c323231-322989 [Vibrio cholerae IEC224]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT26143 NC_016945:c323231-322989 [Vibrio cholerae IEC224]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0K9UJR8

Antitoxin

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Source
ID
Structure
AlphaFold DBQ7DCR7

References