26143

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 322653..323231 Replicon chromosome II
Accession NC_016945
Organism Vibrio cholerae IEC224

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag O3Y_RS15425 Protein ID WP_001180243.1
Coordinates 322653..322970 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag O3Y_RS15430 Protein ID WP_000557292.1
Coordinates 322989..323231 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O3Y_RS15390 318177..318359 + 183 WP_000923340.1 DUF645 family protein -
O3Y_RS15400 318713..318895 + 183 WP_000923153.1 DUF645 family protein -
O3Y_RS15405 319090..319767 + 678 WP_000254617.1 HNH endonuclease -
O3Y_RS15410 319929..321137 + 1209 WP_000272282.1 deoxyguanosinetriphosphate triphosphohydrolase family protein -
O3Y_RS15415 321299..322003 + 705 WP_000087610.1 HNH endonuclease -
O3Y_RS15420 322161..322499 + 339 WP_000713853.1 hypothetical protein -
O3Y_RS15425 322653..322970 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
O3Y_RS15430 322989..323231 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
O3Y_RS15435 323475..323861 + 387 WP_001015867.1 NUDIX hydrolase -
O3Y_RS19615 323918..324031 + 114 WP_001900214.1 hypothetical protein -
O3Y_RS15440 323980..324261 + 282 WP_001894429.1 DUF1289 domain-containing protein -
O3Y_RS15450 324519..325055 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
O3Y_RS15455 325192..325707 + 516 WP_001201510.1 lipocalin family protein -
O3Y_RS15460 325857..326354 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
O3Y_RS15465 326351..326623 - 273 WP_000246253.1 DUF1778 domain-containing protein -
O3Y_RS20140 327016..327141 + 126 WP_001900195.1 DUF645 family protein -
O3Y_RS20145 327157..327195 + 39 WP_106019118.1 hypothetical protein -
O3Y_RS15475 327391..327837 + 447 WP_000006157.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304637..435582 130945
inside Integron - - 309717..435206 125489


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T26143 WP_001180243.1 NC_016945:c322970-322653 [Vibrio cholerae IEC224]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T26143 NC_016945:c322970-322653 [Vibrio cholerae IEC224]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT26143 WP_000557292.1 NC_016945:c323231-322989 [Vibrio cholerae IEC224]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT26143 NC_016945:c323231-322989 [Vibrio cholerae IEC224]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References