58263

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 356253..356831 Replicon chromosome
Accession NZ_CP013306
Organism Vibrio cholerae strain CRC1106

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag ASZ81_RS16025 Protein ID WP_001180243.1
Coordinates 356253..356570 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag ASZ81_RS16030 Protein ID WP_000557292.1
Coordinates 356589..356831 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ81_RS15995 351777..351959 + 183 WP_000923340.1 DUF645 family protein -
ASZ81_RS16000 352313..352495 + 183 WP_000923153.1 DUF645 family protein -
ASZ81_RS16005 352690..353367 + 678 WP_000254617.1 HNH endonuclease -
ASZ81_RS16010 353529..354737 + 1209 WP_000272282.1 deoxyguanosinetriphosphate triphosphohydrolase family protein -
ASZ81_RS16015 354899..355603 + 705 WP_000087610.1 HNH endonuclease -
ASZ81_RS16020 355761..356099 + 339 WP_000713853.1 hypothetical protein -
ASZ81_RS16025 356253..356570 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ASZ81_RS16030 356589..356831 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ASZ81_RS16035 357075..357461 + 387 WP_001015867.1 NUDIX hydrolase -
ASZ81_RS16040 357518..357631 + 114 WP_001900214.1 hypothetical protein -
ASZ81_RS16045 357580..357861 + 282 WP_001894429.1 DUF1289 domain-containing protein -
ASZ81_RS16055 358119..358655 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
ASZ81_RS16060 358792..359307 + 516 WP_001201509.1 lipocalin family protein -
ASZ81_RS16065 359457..359954 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
ASZ81_RS16070 359951..360223 - 273 WP_000246254.1 DUF1778 domain-containing protein -
ASZ81_RS20490 360616..360741 + 126 WP_001900195.1 DUF645 family protein -
ASZ81_RS20495 360757..360795 + 39 WP_106019118.1 hypothetical protein -
ASZ81_RS16080 360991..361437 + 447 WP_000006157.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304741..463550 158809
inside Integron - - 309821..463174 153353


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T58263 WP_001180243.1 NZ_CP013306:c356570-356253 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T58263 NZ_CP013306:c356570-356253 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT58263 WP_000557292.1 NZ_CP013306:c356831-356589 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT58263 NZ_CP013306:c356831-356589 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References