Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 356253..356831 Replicon chromosome
Accession NZ_CP013306
Organism Vibrio cholerae strain CRC1106

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag ASZ81_RS16025 Protein ID WP_001180243.1
Coordinates 356253..356570 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag ASZ81_RS16030 Protein ID WP_000557292.1
Coordinates 356589..356831 (-) Length 81 a.a.

Genomic Context

ASZ81_RS15995ASZ81_RS16000ASZ81_RS16005ASZ81_RS16010ASZ81_RS16015ASZ81_RS16020ASZ81_RS16035ASZ81_RS16040ASZ81_RS16045ASZ81_RS16055ASZ81_RS16060ASZ81_RS20490ASZ81_RS20495ASZ81_RS16080ASZ81_RS16025ASZ81_RS16030ASZ81_RS16065ASZ81_RS16070
Location: 351777..351959 (183 bp)
Type: Others
Protein ID: WP_000923340.1
Location: 352313..352495 (183 bp)
Type: Others
Protein ID: WP_000923153.1
Location: 352690..353367 (678 bp)
Type: Others
Protein ID: WP_000254617.1
Location: 353529..354737 (1209 bp)
Type: Others
Protein ID: WP_000272282.1
Location: 354899..355603 (705 bp)
Type: Others
Protein ID: WP_000087610.1
Location: 355761..356099 (339 bp)
Type: Others
Protein ID: WP_000713853.1
Location: 357075..357461 (387 bp)
Type: Others
Protein ID: WP_001015867.1
Location: 357518..357631 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 357580..357861 (282 bp)
Type: Others
Protein ID: WP_001894429.1
Location: 358119..358655 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 358792..359307 (516 bp)
Type: Others
Protein ID: WP_001201509.1
Location: 360616..360741 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 360757..360795 (39 bp)
Type: Others
Protein ID: WP_106019118.1
Location: 360991..361437 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 356253..356570 (318 bp)
Type: Toxin
Protein ID: WP_001180243.1
Location: 356589..356831 (243 bp)
Type: Antitoxin
Protein ID: WP_000557292.1
Location: 359457..359954 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 359951..360223 (273 bp)
Type: Others
Protein ID: WP_000246254.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ81_RS15995351777..351959+183WP_000923340.1DUF645 family protein-
ASZ81_RS16000352313..352495+183WP_000923153.1DUF645 family protein-
ASZ81_RS16005352690..353367+678WP_000254617.1HNH endonuclease-
ASZ81_RS16010353529..354737+1209WP_000272282.1deoxyguanosinetriphosphate triphosphohydrolase family protein-
ASZ81_RS16015354899..355603+705WP_000087610.1HNH endonuclease-
ASZ81_RS16020355761..356099+339WP_000713853.1hypothetical protein-
ASZ81_RS16025356253..356570-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxinToxin
ASZ81_RS16030356589..356831-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
ASZ81_RS16035357075..357461+387WP_001015867.1NUDIX hydrolase-
ASZ81_RS16040357518..357631+114WP_001900214.1hypothetical protein-
ASZ81_RS16045357580..357861+282WP_001894429.1DUF1289 domain-containing protein-
ASZ81_RS16055358119..358655+537WP_000469482.1GNAT family N-acetyltransferase-
ASZ81_RS16060358792..359307+516WP_001201509.1lipocalin family protein-
ASZ81_RS16065359457..359954-498WP_000982260.1GNAT family N-acetyltransferase-
ASZ81_RS16070359951..360223-273WP_000246254.1DUF1778 domain-containing protein-
ASZ81_RS20490360616..360741+126WP_001900195.1DUF645 family protein-
ASZ81_RS20495360757..360795+39WP_106019118.1hypothetical protein-
ASZ81_RS16080360991..361437+447WP_000006157.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304741..463550158809
insideIntegron--309821..463174153353


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T58263 WP_001180243.1 NZ_CP013306:c356570-356253 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T58263 NZ_CP013306:c356570-356253 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT58263 WP_000557292.1 NZ_CP013306:c356831-356589 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT58263 NZ_CP013306:c356831-356589 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0K9UJR8

Antitoxin

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Source
ID
Structure
AlphaFold DBQ7DCR7

References