Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 975571..976149 Replicon chromosome
Accession NZ_LT992487
Organism Vibrio cholerae strain 4295STDY6534216

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag DG247_RS19180 Protein ID WP_001180243.1
Coordinates 975832..976149 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag DG247_RS19175 Protein ID WP_000557292.1
Coordinates 975571..975813 (+) Length 81 a.a.

Genomic Context

DG247_RS19130DG247_RS19135DG247_RS19175DG247_RS19180DG247_RS19110DG247_RS19120DG247_RS19125DG247_RS19140DG247_RS19145DG247_RS19160DG247_RS19165DG247_RS19170DG247_RS19190DG247_RS19195DG247_RS19200DG247_RS19205DG247_RS19215DG247_RS19220
Location: 972179..972451 (273 bp)
Type: Others
Protein ID: WP_000246253.1
Location: 972448..972945 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 975571..975813 (243 bp)
Type: Antitoxin
Protein ID: WP_000557292.1
Location: 975832..976149 (318 bp)
Type: Toxin
Protein ID: WP_001180243.1
Location: 970965..971411 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 971607..971645 (39 bp)
Type: Others
Protein ID: WP_106019118.1
Location: 971661..971786 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 973095..973610 (516 bp)
Type: Others
Protein ID: WP_001201509.1
Location: 973747..974283 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 974541..974822 (282 bp)
Type: Others
Protein ID: WP_001894429.1
Location: 974771..974884 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 974941..975327 (387 bp)
Type: Others
Protein ID: WP_001015867.1
Location: 976303..976641 (339 bp)
Type: Others
Protein ID: WP_000713853.1
Location: 976799..977503 (705 bp)
Type: Others
Protein ID: WP_000087610.1
Location: 977665..978873 (1209 bp)
Type: Others
Protein ID: WP_000272282.1
Location: 979035..979712 (678 bp)
Type: Others
Protein ID: WP_000254617.1
Location: 979907..980089 (183 bp)
Type: Others
Protein ID: WP_000923153.1
Location: 980443..980625 (183 bp)
Type: Others
Protein ID: WP_000923340.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DG247_RS19110970965..971411-447WP_000006157.1hypothetical protein-
DG247_RS19120971607..971645-39WP_106019118.1hypothetical protein-
DG247_RS19125971661..971786-126WP_001900195.1DUF645 family protein-
DG247_RS19130972179..972451+273WP_000246253.1DUF1778 domain-containing protein-
DG247_RS19135972448..972945+498WP_000982260.1GNAT family N-acetyltransferase-
DG247_RS19140973095..973610-516WP_001201509.1lipocalin family protein-
DG247_RS19145973747..974283-537WP_000469482.1GNAT family N-acetyltransferase-
DG247_RS19160974541..974822-282WP_001894429.1DUF1289 domain-containing protein-
DG247_RS19165974771..974884-114WP_001900214.1hypothetical protein-
DG247_RS19170974941..975327-387WP_001015867.1NUDIX hydrolase-
DG247_RS19175975571..975813+243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
DG247_RS19180975832..976149+318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxinToxin
DG247_RS19190976303..976641-339WP_000713853.1hypothetical protein-
DG247_RS19195976799..977503-705WP_000087610.1HNH endonuclease-
DG247_RS19200977665..978873-1209WP_000272282.1deoxyguanosinetriphosphate triphosphohydrolase family protein-
DG247_RS19205979035..979712-678WP_000254617.1HNH endonuclease-
DG247_RS19215979907..980089-183WP_000923153.1DUF645 family protein-
DG247_RS19220980443..980625-183WP_000923340.1DUF645 family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-897525..99449796972
insideIntegroncatB9-897901..98770989808


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T294364 WP_001180243.1 NZ_LT992487:975832-976149 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT294364 WP_000557292.1 NZ_LT992487:975571-975813 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0K9UJR8

Antitoxin

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Source
ID
Structure
AlphaFold DBQ7DCR7

References