294372

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 389663..390618 Replicon chromosome
Accession NZ_LT992489
Organism Vibrio cholerae strain 4295STDY6534232

Toxin (Protein)


Gene name - Uniprot ID Q9KM94
Locus tag DG176_RS16125 Protein ID WP_000118351.1
Coordinates 389663..390196 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag DG176_RS16130 Protein ID WP_001882332.1
Coordinates 390193..390618 (-) Length 142 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DG176_RS16080 384987..385859 - 873 WP_000254716.1 DUF3800 domain-containing protein -
DG176_RS16085 386034..386252 - 219 WP_071908318.1 GNAT family N-acetyltransferase -
DG176_RS16090 386316..386753 - 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
DG176_RS16095 386872..387081 - 210 Protein_329 GNAT family N-acetyltransferase -
DG176_RS16100 387217..387606 - 390 WP_001081302.1 hypothetical protein -
DG176_RS16105 387763..388680 - 918 WP_000186333.1 alpha/beta hydrolase -
DG176_RS16110 388914..389216 - 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin -
DG176_RS16115 389204..389461 - 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
DG176_RS16125 389663..390196 - 534 WP_000118351.1 GNAT family N-acetyltransferase Toxin
DG176_RS16130 390193..390618 - 426 WP_001882332.1 DUF1778 domain-containing protein Antitoxin
DG176_RS16135 390685..391056 - 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
DG176_RS16140 391197..391484 - 288 WP_000426470.1 hypothetical protein -
DG176_RS16145 391636..392304 - 669 WP_000043871.1 hypothetical protein -
DG176_RS16150 392535..392807 + 273 WP_000246253.1 DUF1778 domain-containing protein -
DG176_RS16155 392804..393301 + 498 WP_000982260.1 GNAT family N-acetyltransferase -
DG176_RS16165 393503..393655 - 153 WP_001884520.1 DUF645 family protein -
DG176_RS16170 393977..394432 - 456 WP_001245327.1 GNAT family N-acetyltransferase -
DG176_RS16175 394560..394847 - 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -
DG176_RS16180 394837..395088 - 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 379325..476297 96972
flank IS/Tn - - 386316..386753 437
inside Integron catB9 - 379701..469509 89808


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(97-153)

Antitoxin

Vibrio phage ICP1, Orf50

(57-133)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 20171.46 Da        Isoelectric Point: 9.1432

>T294372 WP_000118351.1 NZ_LT992489:c390196-389663 [Vibrio cholerae]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ

Download         Length: 534 bp

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15714.41 Da        Isoelectric Point: 7.6659

>AT294372 WP_001882332.1 NZ_LT992489:c390618-390193 [Vibrio cholerae]
MLCLSLVVMRCQPLRRALYSPSPRKLSVRIECALSLAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLGLK
SLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAVKFTEKSGIK

Download         Length: 426 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9KM94

Antitoxin

Source ID Structure

References