Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 60257..60755 Replicon chromosome
Accession NZ_CP007635
Organism Vibrio cholerae strain 2012EL-2176

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag EN18_RS14485 Protein ID WP_000589156.1
Coordinates 60257..60523 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9KMK6
Locus tag EN18_RS14490 Protein ID WP_000643598.1
Coordinates 60510..60755 (+) Length 82 a.a.

Genomic Context

EN18_RS21105EN18_RS21110EN18_RS14450EN18_RS14455EN18_RS20520EN18_RS14460EN18_RS14465EN18_RS21540EN18_RS21545EN18_RS14475EN18_RS14480EN18_RS14485EN18_RS14490EN18_RS14495EN18_RS21550EN18_RS14500EN18_RS14505EN18_RS14510EN18_RS14515EN18_RS14520EN18_RS14525
Location: 55678..55884 (207 bp)
Type: Others
Protein ID: Protein_69
Location: 56084..56185 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 56175..56561 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 56756..57007 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 56980..57129 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 57221..57463 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 57715..57993 (279 bp)
Type: Others
Protein ID: WP_000280324.1
Location: 58368..58511 (144 bp)
Type: Others
Protein ID: Protein_76
Location: 58565..58603 (39 bp)
Type: Others
Protein ID: WP_082798268.1
Location: 58815..59282 (468 bp)
Type: Others
Protein ID: WP_001289288.1
Location: 59410..60072 (663 bp)
Type: Others
Protein ID: WP_000960654.1
Location: 60257..60523 (267 bp)
Type: Toxin
Protein ID: WP_000589156.1
Location: 60510..60755 (246 bp)
Type: Antitoxin
Protein ID: WP_000643598.1
Location: 60851..61645 (795 bp)
Type: Others
Protein ID: WP_001911581.1
Location: 61748..61876 (129 bp)
Type: Others
Protein ID: WP_071908338.1
Location: 61937..62119 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 62335..63339 (1005 bp)
Type: Others
Protein ID: WP_000964920.1
Location: 63492..63851 (360 bp)
Type: Others
Protein ID: WP_001071541.1
Location: 64124..64357 (234 bp)
Type: Others
Protein ID: WP_001890112.1
Location: 64625..65131 (507 bp)
Type: Others
Protein ID: WP_000393074.1
Location: 65288..65674 (387 bp)
Type: Others
Protein ID: WP_000703163.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EN18_RS2110555678..55884+207Protein_69DUF3709 domain-containing protein-
EN18_RS2111056084..56185+102WP_001921603.1hypothetical protein-
EN18_RS1445056175..56561+387WP_000703163.1VOC family protein-
EN18_RS1445556756..57007+252WP_001890111.1TIGR03643 family protein-
EN18_RS2052056980..57129+150WP_071908333.1DUF3265 domain-containing protein-
EN18_RS1446057221..57463+243WP_000107461.1hypothetical protein-
EN18_RS1446557715..57993+279WP_000280324.1DUF3709 domain-containing protein-
EN18_RS2154058368..58511+144Protein_76DUF645 family protein-
EN18_RS2154558565..58603+39WP_082798268.1hypothetical protein-
EN18_RS1447558815..59282+468WP_001289288.1OsmC family protein-
EN18_RS1448059410..60072+663WP_000960654.1hypothetical protein-
EN18_RS1448560257..60523+267WP_000589156.1BrnT family toxinToxin
EN18_RS1449060510..60755+246WP_000643598.1hypothetical proteinAntitoxin
EN18_RS1449560851..61645+795WP_001911581.1hypothetical protein-
EN18_RS2155061748..61876+129WP_071908338.1general secretion pathway protein GspI-
EN18_RS1450061937..62119+183WP_000923182.1DUF645 family protein-
EN18_RS1450562335..63339+1005WP_000964920.1LD-carboxypeptidase-
EN18_RS1451063492..63851+360WP_001071541.1VOC family protein-
EN18_RS1451564124..64357+234WP_001890112.1DUF3709 domain-containing protein-
EN18_RS1452064625..65131+507WP_000393074.1hypothetical protein-
EN18_RS1452565288..65674+387WP_000703163.1VOC family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-31037..137542106505
insideIntegron--36117..137166101049


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T46752 WP_000589156.1 NZ_CP007635:60257-60523 [Vibrio cholerae]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

>T46752 NZ_CP007635:60257-60523 [Vibrio cholerae]
ATGATTAAATTTGAATTTGATGAAAACAAAAGCAGAAGTAATCTCGAAAAGCACGGTATTGATTTTCATACAGCTCAAGG
ATTGTGGAATGATTCAGATCTTATCGAGATCCCTGCTAACACGAGTGATGAGCCCAGATATTTGGTTGTCGGCTTACTAA
ACGGTAAGCATTGGTCAGGAGTAATTACCTACCGAGGTACGAATATCAGGATCATCTCAGTTCGGCGTTCACGGAAAGCG
GAGGTAAGCCTTTATGAAAGCGCATGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9478.77 Da        Isoelectric Point: 6.4832

>AT46752 WP_000643598.1 NZ_CP007635:60510-60755 [Vibrio cholerae]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp

>AT46752 NZ_CP007635:60510-60755 [Vibrio cholerae]
ATGAAAGCGCATGAATTTGATGCCAAGTTTGAAAGTGACGACGATGATATCGTAATGGACTTGGATCTATCGCAAGCTAA
AAGACCGATGCATAAGCAAAAACGAGTCAATGTAGATTTTCCAGCCTGGATGCTTGAGTCCTTGGACAGAGAAGCGAGTC
GTATTGGTGTAACACGTCAATCAATCATTAAAATTTGGCTGGCAGAAAGGTTAGAGAGCGTGTCTCATCATTCAAGTGTG
AGATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A271VMP7

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A271VME2

References