199005

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 365720..366248 Replicon chromosome
Accession NZ_CP072850
Organism Vibrio cholerae MO10

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag KAF59_RS15640 Protein ID WP_000221352.1
Coordinates 365720..366010 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag KAF59_RS15645 Protein ID WP_000213183.1
Coordinates 366000..366248 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KAF59_RS15595 (KAF59_15595) 360990..361100 + 111 WP_134814058.1 DUF3265 domain-containing protein -
KAF59_RS18885 361139..361249 + 111 Protein_362 acetyltransferase -
KAF59_RS15600 (KAF59_15600) 361277..361402 + 126 WP_001944767.1 DUF645 family protein -
KAF59_RS18890 361365..361481 + 117 WP_001889170.1 hypothetical protein -
KAF59_RS15610 (KAF59_15610) 361669..362673 + 1005 WP_000964925.1 LD-carboxypeptidase -
KAF59_RS15615 (KAF59_15615) 362826..363272 + 447 WP_000128977.1 hypothetical protein -
KAF59_RS15620 (KAF59_15620) 363392..364321 + 930 WP_000335802.1 hypothetical protein -
KAF59_RS15625 (KAF59_15625) 364318..364428 + 111 WP_071917832.1 DUF3265 domain-containing protein -
KAF59_RS15630 (KAF59_15630) 364456..364932 + 477 WP_001047180.1 GNAT family N-acetyltransferase -
KAF59_RS15635 (KAF59_15635) 365123..365584 + 462 WP_001911752.1 lipocalin family protein -
KAF59_RS15640 (KAF59_15640) 365720..366010 - 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KAF59_RS15645 (KAF59_15645) 366000..366248 - 249 WP_000213183.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KAF59_RS15650 (KAF59_15650) 366819..367472 + 654 WP_000036957.1 site-specific DNA-methyltransferase -
KAF59_RS15655 (KAF59_15655) 367744..368169 + 426 WP_000415748.1 hypothetical protein -
KAF59_RS15660 (KAF59_15660) 368377..368772 + 396 WP_000649527.1 DUF3465 domain-containing protein -
KAF59_RS15665 (KAF59_15665) 368924..369454 + 531 WP_000415563.1 hypothetical protein -
KAF59_RS15670 (KAF59_15670) 369592..370092 + 501 WP_000789723.1 hypothetical protein -
KAF59_RS15675 (KAF59_15675) 370248..370646 + 399 WP_001882293.1 hypothetical protein -
KAF59_RS15680 (KAF59_15680) 370746..371210 - 465 WP_000140244.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306928..402189 95261
inside Integron catB9 - 312008..401813 89805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T199005 WP_000221352.1 NZ_CP072850:c366010-365720 [Vibrio cholerae MO10]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T199005 NZ_CP097096:c39766-39368 [Escherichia coli]
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTCACGATAAAGAACAAACCCGCCAGCGTCAGGGAGCGTTTTAA
CCTGAACCAGGGGAGAATGTGTATCAGTTCGGTCACCCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGATGTTCTGGATTACGACGCTGCCGCAGCCACACACAGC
GGCCAGATAAGAGCAGAACTTGCCCGTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGACTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGACGGTCTGAGAATTGAAGACTGGAGCTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT199005 WP_000213183.1 NZ_CP072850:c366248-366000 [Vibrio cholerae MO10]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT199005 NZ_CP097096:c39993-39766 [Escherichia coli]
ATGGAAACCACCGTATTTTTCAGCAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTGCCGGAAAACGTAAA
ACGCGTTGAAGTGATTGCTGTCGGACGAACCAGAATCATTACGCCAGCCGGAGAGACATGGGACGAATGGTTCGACGGAC
ACAACGTCAGCGCCGATTTTATGGATAACAGGGAACAGCCCGGCATGCAGGAAAGGGAGTCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H9L4R3

Antitoxin

Source ID Structure
AlphaFold DB A0A366A3W8

References