Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 365720..366248 Replicon chromosome
Accession NZ_CP072850
Organism Vibrio cholerae MO10

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag KAF59_RS15640 Protein ID WP_000221352.1
Coordinates 365720..366010 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag KAF59_RS15645 Protein ID WP_000213183.1
Coordinates 366000..366248 (-) Length 83 a.a.

Genomic Context

KAF59_RS15595KAF59_RS18885KAF59_RS15600KAF59_RS18890KAF59_RS15610KAF59_RS15615KAF59_RS15620KAF59_RS15625KAF59_RS15630KAF59_RS15635KAF59_RS15650KAF59_RS15655KAF59_RS15660KAF59_RS15665KAF59_RS15670KAF59_RS15675KAF59_RS15640KAF59_RS15645KAF59_RS15680
Location: 360990..361100 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 361139..361249 (111 bp)
Type: Others
Protein ID: Protein_362
Location: 361277..361402 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 361365..361481 (117 bp)
Type: Others
Protein ID: WP_001889170.1
Location: 361669..362673 (1005 bp)
Type: Others
Protein ID: WP_000964925.1
Location: 362826..363272 (447 bp)
Type: Others
Protein ID: WP_000128977.1
Location: 363392..364321 (930 bp)
Type: Others
Protein ID: WP_000335802.1
Location: 364318..364428 (111 bp)
Type: Others
Protein ID: WP_071917832.1
Location: 364456..364932 (477 bp)
Type: Others
Protein ID: WP_001047180.1
Location: 365123..365584 (462 bp)
Type: Others
Protein ID: WP_001911752.1
Location: 366819..367472 (654 bp)
Type: Others
Protein ID: WP_000036957.1
Location: 367744..368169 (426 bp)
Type: Others
Protein ID: WP_000415748.1
Location: 368377..368772 (396 bp)
Type: Others
Protein ID: WP_000649527.1
Location: 368924..369454 (531 bp)
Type: Others
Protein ID: WP_000415563.1
Location: 369592..370092 (501 bp)
Type: Others
Protein ID: WP_000789723.1
Location: 370248..370646 (399 bp)
Type: Others
Protein ID: WP_001882293.1
Location: 365720..366010 (291 bp)
Type: Toxin
Protein ID: WP_000221352.1
Location: 366000..366248 (249 bp)
Type: Antitoxin
Protein ID: WP_000213183.1
Location: 370746..371210 (465 bp)
Type: Others
Protein ID: WP_000140244.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
KAF59_RS15595 (KAF59_15595)360990..361100+111WP_134814058.1DUF3265 domain-containing protein-
KAF59_RS18885361139..361249+111Protein_362acetyltransferase-
KAF59_RS15600 (KAF59_15600)361277..361402+126WP_001944767.1DUF645 family protein-
KAF59_RS18890361365..361481+117WP_001889170.1hypothetical protein-
KAF59_RS15610 (KAF59_15610)361669..362673+1005WP_000964925.1LD-carboxypeptidase-
KAF59_RS15615 (KAF59_15615)362826..363272+447WP_000128977.1hypothetical protein-
KAF59_RS15620 (KAF59_15620)363392..364321+930WP_000335802.1hypothetical protein-
KAF59_RS15625 (KAF59_15625)364318..364428+111WP_071917832.1DUF3265 domain-containing protein-
KAF59_RS15630 (KAF59_15630)364456..364932+477WP_001047180.1GNAT family N-acetyltransferase-
KAF59_RS15635 (KAF59_15635)365123..365584+462WP_001911752.1lipocalin family protein-
KAF59_RS15640 (KAF59_15640)365720..366010-291WP_000221352.1type II toxin-antitoxin system RelE/ParE family toxinToxin
KAF59_RS15645 (KAF59_15645)366000..366248-249WP_000213183.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
KAF59_RS15650 (KAF59_15650)366819..367472+654WP_000036957.1site-specific DNA-methyltransferase-
KAF59_RS15655 (KAF59_15655)367744..368169+426WP_000415748.1hypothetical protein-
KAF59_RS15660 (KAF59_15660)368377..368772+396WP_000649527.1DUF3465 domain-containing protein-
KAF59_RS15665 (KAF59_15665)368924..369454+531WP_000415563.1hypothetical protein-
KAF59_RS15670 (KAF59_15670)369592..370092+501WP_000789723.1hypothetical protein-
KAF59_RS15675 (KAF59_15675)370248..370646+399WP_001882293.1hypothetical protein-
KAF59_RS15680 (KAF59_15680)370746..371210-465WP_000140244.1hypothetical protein-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-306928..40218995261
insideIntegroncatB9-312008..40181389805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T199005 WP_000221352.1 NZ_CP072850:c366010-365720 [Vibrio cholerae MO10]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T199005 NZ_CP097096:c39766-39368 [Escherichia coli]
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTCACGATAAAGAACAAACCCGCCAGCGTCAGGGAGCGTTTTAA
CCTGAACCAGGGGAGAATGTGTATCAGTTCGGTCACCCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGATGTTCTGGATTACGACGCTGCCGCAGCCACACACAGC
GGCCAGATAAGAGCAGAACTTGCCCGTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGACTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGACGGTCTGAGAATTGAAGACTGGAGCTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT199005 WP_000213183.1 NZ_CP072850:c366248-366000 [Vibrio cholerae MO10]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT199005 NZ_CP097096:c39993-39766 [Escherichia coli]
ATGGAAACCACCGTATTTTTCAGCAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTGCCGGAAAACGTAAA
ACGCGTTGAAGTGATTGCTGTCGGACGAACCAGAATCATTACGCCAGCCGGAGAGACATGGGACGAATGGTTCGACGGAC
ACAACGTCAGCGCCGATTTTATGGATAACAGGGAACAGCCCGGCATGCAGGAAAGGGAGTCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBH9L4R3

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A366A3W8

References