25720

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) dhiT-phd/-
Location 131448..131852 Replicon chromosome
Accession NC_016446
Organism Vibrio cholerae O1 str. 2010EL-1786

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag HJ37_RS14900 Protein ID WP_001114075.1
Coordinates 131583..131852 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag HJ37_RS20045 Protein ID WP_099607150.1
Coordinates 131448..131552 (+) Length 35 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HJ37_RS14865 126949..127866 + 918 WP_000186333.1 alpha/beta hydrolase -
HJ37_RS14870 128023..128412 + 390 WP_001081302.1 hypothetical protein -
HJ37_RS14875 128548..128757 + 210 Protein_202 GNAT family N-acetyltransferase -
HJ37_RS14880 128876..129313 + 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
HJ37_RS14885 129377..129595 + 219 WP_071908318.1 GNAT family N-acetyltransferase -
HJ37_RS14890 129770..130642 + 873 WP_000254716.1 DUF3800 domain-containing protein -
HJ37_RS14895 130792..131391 + 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
HJ37_RS20045 131448..131552 + 105 WP_099607150.1 acetyltransferase Antitoxin
HJ37_RS14900 131583..131852 + 270 WP_001114075.1 DUF4160 domain-containing protein Toxin
HJ37_RS14905 131846..132367 + 522 WP_000921691.1 DUF2442 domain-containing protein -
HJ37_RS20050 132666..132791 + 126 WP_001905700.1 DUF645 family protein -
HJ37_RS14910 133042..133437 + 396 WP_001000867.1 hypothetical protein -
HJ37_RS14915 133576..133854 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
HJ37_RS14920 133851..134135 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
HJ37_RS14925 134329..134844 + 516 WP_000343779.1 GNAT family N-acetyltransferase -
HJ37_RS14930 135028..135441 + 414 WP_000049420.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 31115..136304 105189
inside Integron catB9 - 36195..135928 99733
flank IS/Tn - - 128876..129313 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T25720 WP_001114075.1 NC_016446:131583-131852 [Vibrio cholerae O1 str. 2010EL-1786]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T25720 NC_016446:131583-131852 [Vibrio cholerae O1 str. 2010EL-1786]
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 35 a.a.        Molecular weight: 3991.79 Da        Isoelectric Point: 9.2853

>AT25720 WP_099607150.1 NC_016446:131448-131552 [Vibrio cholerae O1 str. 2010EL-1786]
VVSVVVFEFSSMRCQPLRRALYAYRNCLLKDTLL

Download         Length: 105 bp

>AT25720 NC_016446:131448-131552 [Vibrio cholerae O1 str. 2010EL-1786]
GTGGTTTCGGTTGTTGTGTTTGAGTTTAGTAGTATGCGCTGCCAGCCCCTTAGGCGGGCGTTATATGCTTATAGGAATTG
TCTCCTAAAGGATACGCTGCTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A086SLD6

Antitoxin

Source ID Structure

References