Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) dhiT-phd/-
Location 131448..131852 Replicon chromosome
Accession NC_016446
Organism Vibrio cholerae O1 str. 2010EL-1786

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag HJ37_RS14900 Protein ID WP_001114075.1
Coordinates 131583..131852 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag HJ37_RS20045 Protein ID WP_099607150.1
Coordinates 131448..131552 (+) Length 35 a.a.

Genomic Context

HJ37_RS14865HJ37_RS14870HJ37_RS14875HJ37_RS14880HJ37_RS14885HJ37_RS14890HJ37_RS14895HJ37_RS20045HJ37_RS14900HJ37_RS14905HJ37_RS20050HJ37_RS14910HJ37_RS14925HJ37_RS14930HJ37_RS14915HJ37_RS14920
Location: 126949..127866 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 128023..128412 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 128548..128757 (210 bp)
Type: Others
Protein ID: Protein_202
Location: 128876..129313 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 129377..129595 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 129770..130642 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 130792..131391 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 131448..131552 (105 bp)
Type: Antitoxin
Protein ID: WP_099607150.1
Location: 131583..131852 (270 bp)
Type: Toxin
Protein ID: WP_001114075.1
Location: 131846..132367 (522 bp)
Type: Others
Protein ID: WP_000921691.1
Location: 132666..132791 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 133042..133437 (396 bp)
Type: Others
Protein ID: WP_001000867.1
Location: 134329..134844 (516 bp)
Type: Others
Protein ID: WP_000343779.1
Location: 135028..135441 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 133576..133854 (279 bp)
Type: Others
Protein ID: WP_000578476.1
Location: 133851..134135 (285 bp)
Type: Others
Protein ID: WP_000381183.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HJ37_RS14865126949..127866+918WP_000186333.1alpha/beta hydrolase-
HJ37_RS14870128023..128412+390WP_001081302.1hypothetical protein-
HJ37_RS14875128548..128757+210Protein_202GNAT family N-acetyltransferase-
HJ37_RS14880128876..129313+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
HJ37_RS14885129377..129595+219WP_071908318.1GNAT family N-acetyltransferase-
HJ37_RS14890129770..130642+873WP_000254716.1DUF3800 domain-containing protein-
HJ37_RS14895130792..131391+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
HJ37_RS20045131448..131552+105WP_099607150.1acetyltransferaseAntitoxin
HJ37_RS14900131583..131852+270WP_001114075.1DUF4160 domain-containing proteinToxin
HJ37_RS14905131846..132367+522WP_000921691.1DUF2442 domain-containing protein-
HJ37_RS20050132666..132791+126WP_001905700.1DUF645 family protein-
HJ37_RS14910133042..133437+396WP_001000867.1hypothetical protein-
HJ37_RS14915133576..133854-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family-
HJ37_RS14920133851..134135-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
HJ37_RS14925134329..134844+516WP_000343779.1GNAT family N-acetyltransferase-
HJ37_RS14930135028..135441+414WP_000049420.1VOC family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-31115..136304105189
insideIntegroncatB9-36195..13592899733
flankIS/Tn--128876..129313437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T25720 WP_001114075.1 NC_016446:131583-131852 [Vibrio cholerae O1 str. 2010EL-1786]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T25720 NC_016446:131583-131852 [Vibrio cholerae O1 str. 2010EL-1786]
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 35 a.a.        Molecular weight: 3991.79 Da        Isoelectric Point: 9.2853

>AT25720 WP_099607150.1 NC_016446:131448-131552 [Vibrio cholerae O1 str. 2010EL-1786]
VVSVVVFEFSSMRCQPLRRALYAYRNCLLKDTLL

Download         Length: 105 bp

>AT25720 NC_016446:131448-131552 [Vibrio cholerae O1 str. 2010EL-1786]
GTGGTTTCGGTTGTTGTGTTTGAGTTTAGTAGTATGCGCTGCCAGCCCCTTAGGCGGGCGTTATATGCTTATAGGAATTG
TCTCCTAAAGGATACGCTGCTATAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A086SLD6

Antitoxin

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Source
ID
Structure
No matching records found

References