38676

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 248683..249211 Replicon chromosome
Accession NZ_AP024554
Organism Vibrio cholerae strain IDH-03329

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag K6J80_RS15100 Protein ID WP_000221352.1
Coordinates 248921..249211 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag K6J80_RS15095 Protein ID WP_000213183.1
Coordinates 248683..248931 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J80_RS15060 243722..244186 + 465 WP_000140244.1 hypothetical protein -
K6J80_RS15065 244286..244684 - 399 WP_001882293.1 hypothetical protein -
K6J80_RS15070 244840..245340 - 501 WP_000789723.1 hypothetical protein -
K6J80_RS15075 245478..246008 - 531 WP_000415563.1 hypothetical protein -
K6J80_RS15080 246159..246554 - 396 WP_000649527.1 DUF3465 domain-containing protein -
K6J80_RS15085 246762..247187 - 426 WP_000415748.1 hypothetical protein -
K6J80_RS15090 247459..248112 - 654 WP_000036957.1 site-specific DNA-methyltransferase -
K6J80_RS15095 248683..248931 + 249 WP_000213183.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K6J80_RS15100 248921..249211 + 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6J80_RS15105 249347..249808 - 462 WP_001911752.1 lipocalin family protein -
K6J80_RS15110 249999..250475 - 477 WP_001047180.1 GNAT family N-acetyltransferase -
K6J80_RS18985 250503..250613 - 111 WP_071917832.1 DUF3265 domain-containing protein -
K6J80_RS15115 250610..251539 - 930 WP_000335802.1 hypothetical protein -
K6J80_RS15120 251659..252105 - 447 WP_000128977.1 hypothetical protein -
K6J80_RS15125 252258..253262 - 1005 WP_000964925.1 LD-carboxypeptidase -
K6J80_RS18990 253450..253566 - 117 WP_001889170.1 hypothetical protein -
K6J80_RS15135 253529..253654 - 126 WP_001944767.1 DUF645 family protein -
K6J80_RS18995 253682..253792 - 111 Protein_262 acetyltransferase -
K6J80_RS19000 253831..253941 - 111 WP_134814058.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 213119..319686 106567
inside Integron - - 213119..312856 99737


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T38676 WP_000221352.1 NZ_AP024554:248921-249211 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T38676 NZ_AP024554:248921-249211 [Vibrio cholerae]
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAGTTAGCCGTTCCACTCCAACAGCAGTTCAA
GAAGAAACTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCCAAACTGTCTGGCGCTGAGAACATTTATAAAATAA
AACTTCGGCAGTCTGGTTATCGCTTAGTCTATCAAGTTGAAAATGACATCATCGTAGTTACTGTTTTAGCTGTCGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT38676 WP_000213183.1 NZ_AP024554:248683-248931 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT38676 NZ_AP024554:248683-248931 [Vibrio cholerae]
ATGACCACTAGAATCCTAGCTGATGTTGCAGCAAGCATTACCGAATTTAAAGCAAACCCAATGAAAGTTGCAACTAGTGC
CTTCGGTGCTCCTGTTGCTGTACTCAACCGAAATGAGCCGGCTTTCTACTGCGTCCCTGCAAGCACCTACGAGATCATGA
TGGATAAGCTTGAAGATCTTGAGCTACTGGCTATTGCCAAAGAACGCTTAAGTGAAGACAGCGTATCGGTAAATATCGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H9L4R3

Antitoxin

Source ID Structure
AlphaFold DB A0A366A3W8

References