Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 248683..249211 Replicon chromosome
Accession NZ_AP024554
Organism Vibrio cholerae strain IDH-03329

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag K6J80_RS15100 Protein ID WP_000221352.1
Coordinates 248921..249211 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag K6J80_RS15095 Protein ID WP_000213183.1
Coordinates 248683..248931 (+) Length 83 a.a.

Genomic Context

K6J80_RS15060K6J80_RS15095K6J80_RS15100K6J80_RS15065K6J80_RS15070K6J80_RS15075K6J80_RS15080K6J80_RS15085K6J80_RS15090K6J80_RS15105K6J80_RS15110K6J80_RS18985K6J80_RS15115K6J80_RS15120K6J80_RS15125K6J80_RS18990K6J80_RS15135K6J80_RS18995K6J80_RS19000
Location: 243722..244186 (465 bp)
Type: Others
Protein ID: WP_000140244.1
Location: 248683..248931 (249 bp)
Type: Antitoxin
Protein ID: WP_000213183.1
Location: 248921..249211 (291 bp)
Type: Toxin
Protein ID: WP_000221352.1
Location: 244286..244684 (399 bp)
Type: Others
Protein ID: WP_001882293.1
Location: 244840..245340 (501 bp)
Type: Others
Protein ID: WP_000789723.1
Location: 245478..246008 (531 bp)
Type: Others
Protein ID: WP_000415563.1
Location: 246159..246554 (396 bp)
Type: Others
Protein ID: WP_000649527.1
Location: 246762..247187 (426 bp)
Type: Others
Protein ID: WP_000415748.1
Location: 247459..248112 (654 bp)
Type: Others
Protein ID: WP_000036957.1
Location: 249347..249808 (462 bp)
Type: Others
Protein ID: WP_001911752.1
Location: 249999..250475 (477 bp)
Type: Others
Protein ID: WP_001047180.1
Location: 250503..250613 (111 bp)
Type: Others
Protein ID: WP_071917832.1
Location: 250610..251539 (930 bp)
Type: Others
Protein ID: WP_000335802.1
Location: 251659..252105 (447 bp)
Type: Others
Protein ID: WP_000128977.1
Location: 252258..253262 (1005 bp)
Type: Others
Protein ID: WP_000964925.1
Location: 253450..253566 (117 bp)
Type: Others
Protein ID: WP_001889170.1
Location: 253529..253654 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 253682..253792 (111 bp)
Type: Others
Protein ID: Protein_262
Location: 253831..253941 (111 bp)
Type: Others
Protein ID: WP_134814058.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K6J80_RS15060243722..244186+465WP_000140244.1hypothetical protein-
K6J80_RS15065244286..244684-399WP_001882293.1hypothetical protein-
K6J80_RS15070244840..245340-501WP_000789723.1hypothetical protein-
K6J80_RS15075245478..246008-531WP_000415563.1hypothetical protein-
K6J80_RS15080246159..246554-396WP_000649527.1DUF3465 domain-containing protein-
K6J80_RS15085246762..247187-426WP_000415748.1hypothetical protein-
K6J80_RS15090247459..248112-654WP_000036957.1site-specific DNA-methyltransferase-
K6J80_RS15095248683..248931+249WP_000213183.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
K6J80_RS15100248921..249211+291WP_000221352.1type II toxin-antitoxin system RelE/ParE family toxinToxin
K6J80_RS15105249347..249808-462WP_001911752.1lipocalin family protein-
K6J80_RS15110249999..250475-477WP_001047180.1GNAT family N-acetyltransferase-
K6J80_RS18985250503..250613-111WP_071917832.1DUF3265 domain-containing protein-
K6J80_RS15115250610..251539-930WP_000335802.1hypothetical protein-
K6J80_RS15120251659..252105-447WP_000128977.1hypothetical protein-
K6J80_RS15125252258..253262-1005WP_000964925.1LD-carboxypeptidase-
K6J80_RS18990253450..253566-117WP_001889170.1hypothetical protein-
K6J80_RS15135253529..253654-126WP_001944767.1DUF645 family protein-
K6J80_RS18995253682..253792-111Protein_262acetyltransferase-
K6J80_RS19000253831..253941-111WP_134814058.1DUF3265 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-213119..319686106567
insideIntegron--213119..31285699737


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T38676 WP_000221352.1 NZ_AP024554:248921-249211 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T38676 NZ_AP024554:248921-249211 [Vibrio cholerae]
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAGTTAGCCGTTCCACTCCAACAGCAGTTCAA
GAAGAAACTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCCAAACTGTCTGGCGCTGAGAACATTTATAAAATAA
AACTTCGGCAGTCTGGTTATCGCTTAGTCTATCAAGTTGAAAATGACATCATCGTAGTTACTGTTTTAGCTGTCGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT38676 WP_000213183.1 NZ_AP024554:248683-248931 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT38676 NZ_AP024554:248683-248931 [Vibrio cholerae]
ATGACCACTAGAATCCTAGCTGATGTTGCAGCAAGCATTACCGAATTTAAAGCAAACCCAATGAAAGTTGCAACTAGTGC
CTTCGGTGCTCCTGTTGCTGTACTCAACCGAAATGAGCCGGCTTTCTACTGCGTCCCTGCAAGCACCTACGAGATCATGA
TGGATAAGCTTGAAGATCTTGAGCTACTGGCTATTGCCAAAGAACGCTTAAGTGAAGACAGCGTATCGGTAAATATCGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBH9L4R3

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A366A3W8

References