45807

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 349535..350073 Replicon chromosome
Accession NZ_CP006948
Organism Vibrio cholerae O1 str. KW3

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag N900_RS15685 Protein ID WP_000802136.1
Coordinates 349535..349834 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag N900_RS15690 Protein ID WP_001107719.1
Coordinates 349831..350073 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N900_RS15650 345470..345652 + 183 WP_000923182.1 DUF645 family protein -
N900_RS15655 345852..346325 + 474 WP_001161076.1 GrpB family protein -
N900_RS19510 346340..346432 + 93 WP_014378730.1 DUF3265 domain-containing protein -
N900_RS15660 346474..347100 + 627 WP_000365424.1 LysE family translocator -
N900_RS15665 347223..347921 + 699 WP_001890502.1 hypothetical protein -
N900_RS19515 347931..348041 + 111 WP_079857360.1 DUF3265 domain-containing protein -
N900_RS15675 348619..348798 + 180 WP_001883058.1 DUF645 family protein -
N900_RS15680 349012..349407 + 396 WP_000870857.1 DUF3465 domain-containing protein -
N900_RS15685 349535..349834 - 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N900_RS15690 349831..350073 - 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
N900_RS15695 350302..350880 + 579 WP_000110120.1 hypothetical protein -
N900_RS19525 350902..350994 + 93 WP_014164112.1 DUF3265 domain-containing protein -
N900_RS15705 351418..352101 + 684 WP_000877436.1 hypothetical protein -
N900_RS15710 352315..352581 + 267 WP_000937852.1 hypothetical protein -
N900_RS15715 352736..353335 + 600 WP_000429495.1 hypothetical protein -
N900_RS15720 353597..354550 + 954 WP_080033341.1 restriction endonuclease -
N900_RS19540 354516..354656 + 141 WP_001883049.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304645..411088 106443
inside Integron - - 309725..410760 101035


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T45807 WP_000802136.1 NZ_CP006948:c349834-349535 [Vibrio cholerae O1 str. KW3]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T45807 NZ_CP006948:c349834-349535 [Vibrio cholerae O1 str. KW3]
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT45807 WP_001107719.1 NZ_CP006948:c350073-349831 [Vibrio cholerae O1 str. KW3]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT45807 NZ_CP006948:c350073-349831 [Vibrio cholerae O1 str. KW3]
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGGCGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7R5A

Antitoxin

Source ID Structure
AlphaFold DB A0A151JFU4

References