294368

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 381494..382053 Replicon chromosome
Accession NZ_LT992489
Organism Vibrio cholerae strain 4295STDY6534232

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag DG176_RS16040 Protein ID WP_000578476.1
Coordinates 381775..382053 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag DG176_RS16035 Protein ID WP_000381183.1
Coordinates 381494..381778 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DG176_RS16020 380188..380601 - 414 WP_000049420.1 VOC family protein -
DG176_RS16030 380785..381300 - 516 WP_000343779.1 GNAT family N-acetyltransferase -
DG176_RS16035 381494..381778 + 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
DG176_RS16040 381775..382053 + 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
DG176_RS16045 382192..382587 - 396 WP_001000867.1 hypothetical protein -
DG176_RS16055 382838..382963 - 126 WP_001905700.1 DUF645 family protein -
DG176_RS16060 383262..383783 - 522 WP_000921691.1 DUF2442 domain-containing protein -
DG176_RS16065 383777..384046 - 270 WP_001114075.1 DUF4160 domain-containing protein -
DG176_RS16070 384077..384181 - 105 WP_099607150.1 acetyltransferase -
DG176_RS16075 384238..384837 - 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
DG176_RS16080 384987..385859 - 873 WP_000254716.1 DUF3800 domain-containing protein -
DG176_RS16085 386034..386252 - 219 WP_071908318.1 GNAT family N-acetyltransferase -
DG176_RS16090 386316..386753 - 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 379325..476297 96972
flank IS/Tn - - 386316..386753 437
inside Integron catB9 - 379701..469509 89808


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T294368 WP_000578476.1 NZ_LT992489:381775-382053 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT294368 WP_000381183.1 NZ_LT992489:381494-381778 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9K2M8

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References