Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 424289..425244 Replicon chromosome II
Accession NC_016945
Organism Vibrio cholerae IEC224

Toxin (Protein)


Gene name - Uniprot ID Q9KM94
Locus tag O3Y_RS16220 Protein ID WP_000118351.1
Coordinates 424711..425244 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag O3Y_RS16215 Protein ID WP_001882332.1
Coordinates 424289..424714 (+) Length 142 a.a.

Genomic Context

O3Y_RS16170O3Y_RS16175O3Y_RS16180O3Y_RS16185O3Y_RS16200O3Y_RS16205O3Y_RS16210O3Y_RS16215O3Y_RS16220O3Y_RS16225O3Y_RS16230O3Y_RS16235O3Y_RS16240O3Y_RS16245O3Y_RS16250O3Y_RS16255O3Y_RS16260O3Y_RS16190O3Y_RS16195
Location: 419819..420070 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 420060..420347 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 420475..420930 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 421252..421404 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 422603..423271 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 423423..423710 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 423851..424222 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 424289..424714 (426 bp)
Type: Antitoxin
Protein ID: WP_001882332.1
Location: 424711..425244 (534 bp)
Type: Toxin
Protein ID: WP_000118351.1
Location: 425446..425703 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 425691..425993 (303 bp)
Type: Others
Protein ID: WP_000229317.1
Location: 426227..427144 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 427301..427690 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 427826..428035 (210 bp)
Type: Others
Protein ID: Protein_464
Location: 428154..428591 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 428655..428873 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 429048..429920 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 421606..422103 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 422100..422372 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
O3Y_RS16170419819..420070+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
O3Y_RS16175420060..420347+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
O3Y_RS16180420475..420930+456WP_001245327.1GNAT family N-acetyltransferase-
O3Y_RS16185421252..421404+153WP_001884520.1DUF645 family protein-
O3Y_RS16190421606..422103-498WP_000982260.1GNAT family N-acetyltransferase-
O3Y_RS16195422100..422372-273WP_000246253.1DUF1778 domain-containing protein-
O3Y_RS16200422603..423271+669WP_000043871.1hypothetical protein-
O3Y_RS16205423423..423710+288WP_000426470.1hypothetical protein-
O3Y_RS16210423851..424222+372WP_001164080.1nucleotide pyrophosphohydrolase-
O3Y_RS16215424289..424714+426WP_001882332.1DUF1778 domain-containing proteinAntitoxin
O3Y_RS16220424711..425244+534WP_000118351.1GNAT family N-acetyltransferaseToxin
O3Y_RS16225425446..425703+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
O3Y_RS16230425691..425993+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxin-
O3Y_RS16235426227..427144+918WP_000186333.1alpha/beta hydrolase-
O3Y_RS16240427301..427690+390WP_001081302.1hypothetical protein-
O3Y_RS16245427826..428035+210Protein_464GNAT family N-acetyltransferase-
O3Y_RS16250428154..428591+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
O3Y_RS16255428655..428873+219WP_071908318.1GNAT family N-acetyltransferase-
O3Y_RS16260429048..429920+873WP_000254716.1DUF3800 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304637..435582130945
insideIntegron--309717..435206125489
flankIS/Tn--428154..428591437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(97-153)

Antitoxin

Vibrio phage ICP1, Orf50

(57-133)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 20171.46 Da        Isoelectric Point: 9.1432

>T26156 WP_000118351.1 NC_016945:424711-425244 [Vibrio cholerae IEC224]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ

Download         Length: 534 bp

>T26156 NC_016945:424711-425244 [Vibrio cholerae IEC224]
GTGAGTTGGGGCAAAGAGTTTGTAGAACTTAGTAAATCAAAGCATGACCGCGACTCATTTGACTGTGGTGAGCAAGAGCT
AAACACATTTATCAAAACTCAAGCTGCAAAGCACATGCAAGCAGGTATTAGCCGAACAATGGTTTTACCTAGTGCTCACC
CACTGTTAAATCAAAAATTCGCTATTTGTGCCTTTTATAGTGTTGCACCGAGCTCAATCAGCCGAGAAACATTACCGGCA
CAATTAGCAAAGAAACTACCGAGGTATCCAATCCCTGTTTTTCTGTTGGCTCAGTTAGCTGTGCACAAAGAATTTCACGG
TTCTGGACTTGGAAAGGTCAGTCTAATCCGTGCGCTGAAGTACTTGTGGGAAGTGAATCATCACATGAGAGCATACGCAA
TAGTTGTGGATTGTCTGACAGATTCCGCTCAAGCGTTCTATACGAAGTTCGGCTTTGAAGTATTGTGCGAACATAATGAG
CGTATTCGTATGTTCTTACCGATGAAAACGGTAGAACAACTTTTTAATCAATAG

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15714.41 Da        Isoelectric Point: 7.6659

>AT26156 WP_001882332.1 NC_016945:424289-424714 [Vibrio cholerae IEC224]
MLCLSLVVMRCQPLRRALYSPSPRKLSVRIECALSLAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLGLK
SLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAVKFTEKSGIK

Download         Length: 426 bp

>AT26156 NC_016945:424289-424714 [Vibrio cholerae IEC224]
TTGTTGTGTTTGAGTTTAGTGGTCATGCGTTGTCAGCCCCTTAGACGGGCGTTATATTCTCCCTCGCCCCGTAAACTTTC
CGTACGAATTGAATGTGCTTTAAGTTTGGCCTATAATCGCTCAACTGACGGAATGTATCCGTACGCAGGAGGGGTTATGG
CAACGGCACGTTTAGATATCCGCCTTGATGAAGAGATCAAGGCAAAAGCTGAAAAGGCATCGGCTTTACTTGGTTTAAAA
AGTCTCACTGAATATGTGGTGAGACTTATGGACGAAGATGCGACTCATGTTATTGAGGAGCATGAAAGTATTATGGTTAA
AGACAGTGTTTTTGACGAGTTTATGGCTGCGTGTAATAAAGTAAAAGCACCGAATCAAGCTTTGCTTGAAGCTGTTAAAT
TTACAGAGAAGAGCGGTATCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9KM94

Antitoxin

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Source
ID
Structure
No matching records found

References