26156

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 424289..425244 Replicon chromosome II
Accession NC_016945
Organism Vibrio cholerae IEC224

Toxin (Protein)


Gene name - Uniprot ID Q9KM94
Locus tag O3Y_RS16220 Protein ID WP_000118351.1
Coordinates 424711..425244 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag O3Y_RS16215 Protein ID WP_001882332.1
Coordinates 424289..424714 (+) Length 142 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O3Y_RS16170 419819..420070 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
O3Y_RS16175 420060..420347 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -
O3Y_RS16180 420475..420930 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
O3Y_RS16185 421252..421404 + 153 WP_001884520.1 DUF645 family protein -
O3Y_RS16190 421606..422103 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
O3Y_RS16195 422100..422372 - 273 WP_000246253.1 DUF1778 domain-containing protein -
O3Y_RS16200 422603..423271 + 669 WP_000043871.1 hypothetical protein -
O3Y_RS16205 423423..423710 + 288 WP_000426470.1 hypothetical protein -
O3Y_RS16210 423851..424222 + 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
O3Y_RS16215 424289..424714 + 426 WP_001882332.1 DUF1778 domain-containing protein Antitoxin
O3Y_RS16220 424711..425244 + 534 WP_000118351.1 GNAT family N-acetyltransferase Toxin
O3Y_RS16225 425446..425703 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
O3Y_RS16230 425691..425993 + 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin -
O3Y_RS16235 426227..427144 + 918 WP_000186333.1 alpha/beta hydrolase -
O3Y_RS16240 427301..427690 + 390 WP_001081302.1 hypothetical protein -
O3Y_RS16245 427826..428035 + 210 Protein_464 GNAT family N-acetyltransferase -
O3Y_RS16250 428154..428591 + 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
O3Y_RS16255 428655..428873 + 219 WP_071908318.1 GNAT family N-acetyltransferase -
O3Y_RS16260 429048..429920 + 873 WP_000254716.1 DUF3800 domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304637..435582 130945
inside Integron - - 309717..435206 125489
flank IS/Tn - - 428154..428591 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(97-153)

Antitoxin

(57-133)


Sequences


Toxin        


Download         Length: 178 a.a.        Molecular weight: 20171.46 Da        Isoelectric Point: 9.1432

>T26156 WP_000118351.1 NC_016945:424711-425244 [Vibrio cholerae IEC224]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ

Download         Length: 534 bp

>T26156 NC_016945:424711-425244 [Vibrio cholerae IEC224]
GTGAGTTGGGGCAAAGAGTTTGTAGAACTTAGTAAATCAAAGCATGACCGCGACTCATTTGACTGTGGTGAGCAAGAGCT
AAACACATTTATCAAAACTCAAGCTGCAAAGCACATGCAAGCAGGTATTAGCCGAACAATGGTTTTACCTAGTGCTCACC
CACTGTTAAATCAAAAATTCGCTATTTGTGCCTTTTATAGTGTTGCACCGAGCTCAATCAGCCGAGAAACATTACCGGCA
CAATTAGCAAAGAAACTACCGAGGTATCCAATCCCTGTTTTTCTGTTGGCTCAGTTAGCTGTGCACAAAGAATTTCACGG
TTCTGGACTTGGAAAGGTCAGTCTAATCCGTGCGCTGAAGTACTTGTGGGAAGTGAATCATCACATGAGAGCATACGCAA
TAGTTGTGGATTGTCTGACAGATTCCGCTCAAGCGTTCTATACGAAGTTCGGCTTTGAAGTATTGTGCGAACATAATGAG
CGTATTCGTATGTTCTTACCGATGAAAACGGTAGAACAACTTTTTAATCAATAG

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15714.41 Da        Isoelectric Point: 7.6659

>AT26156 WP_001882332.1 NC_016945:424289-424714 [Vibrio cholerae IEC224]
MLCLSLVVMRCQPLRRALYSPSPRKLSVRIECALSLAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLGLK
SLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAVKFTEKSGIK

Download         Length: 426 bp

>AT26156 NC_016945:424289-424714 [Vibrio cholerae IEC224]
TTGTTGTGTTTGAGTTTAGTGGTCATGCGTTGTCAGCCCCTTAGACGGGCGTTATATTCTCCCTCGCCCCGTAAACTTTC
CGTACGAATTGAATGTGCTTTAAGTTTGGCCTATAATCGCTCAACTGACGGAATGTATCCGTACGCAGGAGGGGTTATGG
CAACGGCACGTTTAGATATCCGCCTTGATGAAGAGATCAAGGCAAAAGCTGAAAAGGCATCGGCTTTACTTGGTTTAAAA
AGTCTCACTGAATATGTGGTGAGACTTATGGACGAAGATGCGACTCATGTTATTGAGGAGCATGAAAGTATTATGGTTAA
AGACAGTGTTTTTGACGAGTTTATGGCTGCGTGTAATAAAGTAAAAGCACCGAATCAAGCTTTGCTTGAAGCTGTTAAAT
TTACAGAGAAGAGCGGTATCAAGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB Q9KM94


Antitoxin

Source ID Structure

References