Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 350026..350564 Replicon chromosome
Accession NZ_CP047298
Organism Vibrio cholerae O1 biovar El Tor strain C6709

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag GTF73_RS15455 Protein ID WP_000802136.1
Coordinates 350026..350325 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag GTF73_RS15460 Protein ID WP_001107719.1
Coordinates 350322..350564 (-) Length 81 a.a.

Genomic Context

GTF73_RS15415GTF73_RS15420GTF73_RS15425GTF73_RS15430GTF73_RS15435GTF73_RS15440GTF73_RS15445GTF73_RS15450GTF73_RS15465GTF73_RS15470GTF73_RS15475GTF73_RS15480GTF73_RS15485GTF73_RS15490GTF73_RS15495GTF73_RS15455GTF73_RS15460
Location: 345961..346143 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 346343..346816 (474 bp)
Type: Others
Protein ID: WP_001161076.1
Location: 346813..346923 (111 bp)
Type: Others
Protein ID: WP_071908312.1
Location: 346965..347591 (627 bp)
Type: Others
Protein ID: WP_000365424.1
Location: 347714..348412 (699 bp)
Type: Others
Protein ID: WP_001890502.1
Location: 348416..348532 (117 bp)
Type: Others
Protein ID: WP_071908339.1
Location: 349110..349289 (180 bp)
Type: Others
Protein ID: WP_001883058.1
Location: 349503..349898 (396 bp)
Type: Others
Protein ID: WP_000870857.1
Location: 350793..351371 (579 bp)
Type: Others
Protein ID: WP_000110120.1
Location: 351375..351485 (111 bp)
Type: Others
Protein ID: WP_071908313.1
Location: 351909..352592 (684 bp)
Type: Others
Protein ID: WP_000877436.1
Location: 352806..353072 (267 bp)
Type: Others
Protein ID: WP_000937852.1
Location: 353227..353826 (600 bp)
Type: Others
Protein ID: WP_000429495.1
Location: 354107..355042 (936 bp)
Type: Others
Protein ID: WP_000051985.1
Location: 355008..355148 (141 bp)
Type: Others
Protein ID: WP_001883049.1
Location: 350026..350325 (300 bp)
Type: Toxin
Protein ID: WP_000802136.1
Location: 350322..350564 (243 bp)
Type: Antitoxin
Protein ID: WP_001107719.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GTF73_RS15415345961..346143+183WP_000923182.1DUF645 family protein-
GTF73_RS15420346343..346816+474WP_001161076.1GrpB family protein-
GTF73_RS15425346813..346923+111WP_071908312.1DUF3265 domain-containing protein-
GTF73_RS15430346965..347591+627WP_000365424.1LysE family translocator-
GTF73_RS15435347714..348412+699WP_001890502.1hypothetical protein-
GTF73_RS15440348416..348532+117WP_071908339.1DUF3265 domain-containing protein-
GTF73_RS15445349110..349289+180WP_001883058.1DUF645 family protein-
GTF73_RS15450349503..349898+396WP_000870857.1DUF3465 domain-containing protein-
GTF73_RS15455350026..350325-300WP_000802136.1type II toxin-antitoxin system RelE/ParE family toxinToxin
GTF73_RS15460350322..350564-243WP_001107719.1type II toxin-antitoxin system ParD family antitoxinAntitoxin
GTF73_RS15465350793..351371+579WP_000110120.1hypothetical protein-
GTF73_RS15470351375..351485+111WP_071908313.1DUF3265 domain-containing protein-
GTF73_RS15475351909..352592+684WP_000877436.1hypothetical protein-
GTF73_RS15480352806..353072+267WP_000937852.1hypothetical protein-
GTF73_RS15485353227..353826+600WP_000429495.1hypothetical protein-
GTF73_RS15490354107..355042+936WP_000051985.1restriction endonuclease-
GTF73_RS15495355008..355148+141WP_001883049.1DUF3265 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-306901..436162129261
insideIntegron--311981..435786123805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T145828 WP_000802136.1 NZ_CP047298:c350325-350026 [Vibrio cholerae O1 biovar El Tor]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T145828 NZ_CP062701:2067-2342 [Escherichia coli O157:H7]
ATGGAACTGAAGTGGAGCAGTAAGGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTAGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGGGAACAGTTATTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT145828 WP_001107719.1 NZ_CP047298:c350564-350322 [Vibrio cholerae O1 biovar El Tor]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT145828 NZ_CP062701:1783-2067 [Escherichia coli O157:H7]
ATGCAAATGAAAAACAATACCGCACAAGCAACAAAAGTCATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGTTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATTGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB7R5A

Antitoxin

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Source
ID
Structure
PDB7R5A
PDB7B22
AlphaFold DBA0A151JFU4

References