145828

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 350026..350564 Replicon chromosome
Accession NZ_CP047298
Organism Vibrio cholerae O1 biovar El Tor strain C6709

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag GTF73_RS15455 Protein ID WP_000802136.1
Coordinates 350026..350325 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag GTF73_RS15460 Protein ID WP_001107719.1
Coordinates 350322..350564 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTF73_RS15415 345961..346143 + 183 WP_000923182.1 DUF645 family protein -
GTF73_RS15420 346343..346816 + 474 WP_001161076.1 GrpB family protein -
GTF73_RS15425 346813..346923 + 111 WP_071908312.1 DUF3265 domain-containing protein -
GTF73_RS15430 346965..347591 + 627 WP_000365424.1 LysE family translocator -
GTF73_RS15435 347714..348412 + 699 WP_001890502.1 hypothetical protein -
GTF73_RS15440 348416..348532 + 117 WP_071908339.1 DUF3265 domain-containing protein -
GTF73_RS15445 349110..349289 + 180 WP_001883058.1 DUF645 family protein -
GTF73_RS15450 349503..349898 + 396 WP_000870857.1 DUF3465 domain-containing protein -
GTF73_RS15455 350026..350325 - 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GTF73_RS15460 350322..350564 - 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
GTF73_RS15465 350793..351371 + 579 WP_000110120.1 hypothetical protein -
GTF73_RS15470 351375..351485 + 111 WP_071908313.1 DUF3265 domain-containing protein -
GTF73_RS15475 351909..352592 + 684 WP_000877436.1 hypothetical protein -
GTF73_RS15480 352806..353072 + 267 WP_000937852.1 hypothetical protein -
GTF73_RS15485 353227..353826 + 600 WP_000429495.1 hypothetical protein -
GTF73_RS15490 354107..355042 + 936 WP_000051985.1 restriction endonuclease -
GTF73_RS15495 355008..355148 + 141 WP_001883049.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306901..436162 129261
inside Integron - - 311981..435786 123805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T145828 WP_000802136.1 NZ_CP047298:c350325-350026 [Vibrio cholerae O1 biovar El Tor]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T145828 NZ_CP062701:2067-2342 [Escherichia coli O157:H7]
ATGGAACTGAAGTGGAGCAGTAAGGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTAGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGGGAACAGTTATTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT145828 WP_001107719.1 NZ_CP047298:c350564-350322 [Vibrio cholerae O1 biovar El Tor]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT145828 NZ_CP062701:1783-2067 [Escherichia coli O157:H7]
ATGCAAATGAAAAACAATACCGCACAAGCAACAAAAGTCATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGTTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATTGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7R5A

Antitoxin

Source ID Structure
AlphaFold DB A0A151JFU4

References