Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 486697..487244 Replicon chromosome
Accession NZ_CP013318
Organism Vibrio cholerae strain NCTC5395

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag ASZ85_RS17135 Protein ID WP_000229317.1
Coordinates 486942..487244 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag ASZ85_RS17130 Protein ID WP_000861987.1
Coordinates 486697..486954 (+) Length 86 a.a.

Genomic Context

ASZ85_RS17080ASZ85_RS17090ASZ85_RS17105ASZ85_RS17110ASZ85_RS17115ASZ85_RS17120ASZ85_RS17125ASZ85_RS17130ASZ85_RS17135ASZ85_RS17140ASZ85_RS17150ASZ85_RS17155ASZ85_RS17160ASZ85_RS17165ASZ85_RS17175ASZ85_RS17180ASZ85_RS21230ASZ85_RS17095ASZ85_RS17100
Location: 481726..482181 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 482503..482655 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 483854..484522 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 484674..484961 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 485102..485473 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 485540..485965 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 485962..486495 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 486697..486954 (258 bp)
Type: Antitoxin
Protein ID: WP_000861987.1
Location: 486942..487244 (303 bp)
Type: Toxin
Protein ID: WP_000229317.1
Location: 487478..488395 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 488552..488941 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 489077..489286 (210 bp)
Type: Others
Protein ID: Protein_549
Location: 489405..489842 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 489906..490124 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 490299..491171 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 491321..491920 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 491977..492081 (105 bp)
Type: Others
Protein ID: WP_099607150.1
Location: 482857..483354 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 483351..483623 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ85_RS17080481726..482181+456WP_001245327.1GNAT family N-acetyltransferase-
ASZ85_RS17090482503..482655+153WP_001884520.1DUF645 family protein-
ASZ85_RS17095482857..483354-498WP_000982260.1GNAT family N-acetyltransferase-
ASZ85_RS17100483351..483623-273WP_000246253.1DUF1778 domain-containing protein-
ASZ85_RS17105483854..484522+669WP_000043871.1hypothetical protein-
ASZ85_RS17110484674..484961+288WP_000426470.1hypothetical protein-
ASZ85_RS17115485102..485473+372WP_001164080.1nucleotide pyrophosphohydrolase-
ASZ85_RS17120485540..485965+426WP_001882332.1DUF1778 domain-containing protein-
ASZ85_RS17125485962..486495+534WP_000118351.1GNAT family N-acetyltransferase-
ASZ85_RS17130486697..486954+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
ASZ85_RS17135486942..487244+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxinToxin
ASZ85_RS17140487478..488395+918WP_000186333.1alpha/beta hydrolase-
ASZ85_RS17150488552..488941+390WP_001081302.1hypothetical protein-
ASZ85_RS17155489077..489286+210Protein_549GNAT family N-acetyltransferase-
ASZ85_RS17160489405..489842+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
ASZ85_RS17165489906..490124+219WP_071908318.1GNAT family N-acetyltransferase-
ASZ85_RS17175490299..491171+873WP_000254716.1DUF3800 domain-containing protein-
ASZ85_RS17180491321..491920+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
ASZ85_RS21230491977..492081+105WP_099607150.1acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--338285..496833158548
insideIntegron--343365..496457153092
flankIS/Tn--489405..489842437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T58408 WP_000229317.1 NZ_CP013318:486942-487244 [Vibrio cholerae]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T58408 NZ_CP013318:486942-487244 [Vibrio cholerae]
ATGGTTGAAATAATTTGGACGGAGCTGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAGTCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT58408 WP_000861987.1 NZ_CP013318:486697-486954 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT58408 NZ_CP013318:486697-486954 [Vibrio cholerae]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9KM92

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1T4SLM9

References