Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 225953..226719 Replicon chromosome
Accession NZ_AP024554
Organism Vibrio cholerae strain IDH-03329

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag K6J80_RS14905 Protein ID WP_000982260.1
Coordinates 226222..226719 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag K6J80_RS14900 Protein ID WP_000246253.1
Coordinates 225953..226225 (+) Length 91 a.a.

Genomic Context

K6J80_RS14900K6J80_RS14905K6J80_RS14860K6J80_RS14865K6J80_RS14870K6J80_RS18935K6J80_RS14875K6J80_RS18940K6J80_RS14885K6J80_RS14890K6J80_RS14895K6J80_RS18945K6J80_RS18950K6J80_RS14910K6J80_RS18955K6J80_RS14915K6J80_RS14920K6J80_RS14925K6J80_RS14930K6J80_RS18960K6J80_RS14935K6J80_RS18965K6J80_RS18970K6J80_RS14945
Location: 225953..226225 (273 bp)
Type: Antitoxin
Protein ID: WP_000246253.1
Location: 226222..226719 (498 bp)
Type: Toxin
Protein ID: WP_000982260.1
Location: 221181..222098 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 222332..222634 (303 bp)
Type: Others
Protein ID: WP_000229317.1
Location: 222622..222879 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 222961..223071 (111 bp)
Type: Others
Protein ID: WP_086010065.1
Location: 223081..223614 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 223611..223880 (270 bp)
Type: Others
Protein ID: WP_000179600.1
Location: 224103..224474 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 224615..224902 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 225054..225722 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 225739..225801 (63 bp)
Type: Others
Protein ID: Protein_206
Location: 226736..226804 (69 bp)
Type: Others
Protein ID: Protein_209
Location: 226921..227025 (105 bp)
Type: Others
Protein ID: WP_228840819.1
Location: 227216..227338 (123 bp)
Type: Others
Protein ID: Protein_211
Location: 227395..227850 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 227978..228265 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 228255..228506 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 228720..229133 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 229208..229318 (111 bp)
Type: Others
Protein ID: WP_082798255.1
Location: 229321..229722 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 229722..229892 (171 bp)
Type: Others
Protein ID: WP_001080654.1
Location: 230016..230414 (399 bp)
Type: Others
Protein ID: Protein_219
Location: 230551..230857 (307 bp)
Type: Others
Protein ID: Protein_220
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K6J80_RS14860221181..222098-918WP_000186333.1alpha/beta hydrolase-
K6J80_RS14865222332..222634-303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxin-
K6J80_RS14870222622..222879-258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
K6J80_RS18935222961..223071-111WP_086010065.1DUF3265 domain-containing protein-
K6J80_RS14875223081..223614-534WP_000118351.1GNAT family N-acetyltransferase-
K6J80_RS18940223611..223880-270WP_000179600.1DUF1778 domain-containing protein-
K6J80_RS14885224103..224474-372WP_001164080.1MazG nucleotide pyrophosphohydrolase domain-containing protein-
K6J80_RS14890224615..224902-288WP_000426470.1hypothetical protein-
K6J80_RS14895225054..225722-669WP_000043871.1hypothetical protein-
K6J80_RS18945225739..225801-63Protein_206acetyltransferase-
K6J80_RS14900225953..226225+273WP_000246253.1DUF1778 domain-containing proteinAntitoxin
K6J80_RS14905226222..226719+498WP_000982260.1GNAT family N-acetyltransferaseToxin
K6J80_RS18950226736..226804-69Protein_209acetyltransferase-
K6J80_RS14910226921..227025-105WP_228840819.1DUF645 family protein-
K6J80_RS18955227216..227338-123Protein_211acetyltransferase-
K6J80_RS14915227395..227850-456WP_001245327.1GNAT family N-acetyltransferase-
K6J80_RS14920227978..228265-288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
K6J80_RS14925228255..228506-252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
K6J80_RS14930228720..229133-414WP_000049417.1VOC family protein-
K6J80_RS18960229208..229318-111WP_082798255.1DUF3265 domain-containing protein-
K6J80_RS14935229321..229722-402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
K6J80_RS18965229722..229892-171WP_001080654.1hypothetical protein-
K6J80_RS18970230016..230414-399Protein_219GNAT family N-acetyltransferase-
K6J80_RS14945230551..230857-307Protein_220CatB-related O-acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-213119..319686106567
insideIntegron--213119..31285699737
flankIS/Tn--230925..231905980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T38672 WP_000982260.1 NZ_AP024554:226222-226719 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T38672 NZ_AP024554:226222-226719 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT38672 WP_000246253.1 NZ_AP024554:225953-226225 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT38672 NZ_AP024554:225953-226225 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0KGB1

Antitoxin

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Source
ID
Structure
PDB1Y9B
AlphaFold DBA0A0F2IC79

References