38672

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 225953..226719 Replicon chromosome
Accession NZ_AP024554
Organism Vibrio cholerae strain IDH-03329

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag K6J80_RS14905 Protein ID WP_000982260.1
Coordinates 226222..226719 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag K6J80_RS14900 Protein ID WP_000246253.1
Coordinates 225953..226225 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J80_RS14860 221181..222098 - 918 WP_000186333.1 alpha/beta hydrolase -
K6J80_RS14865 222332..222634 - 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin -
K6J80_RS14870 222622..222879 - 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
K6J80_RS18935 222961..223071 - 111 WP_086010065.1 DUF3265 domain-containing protein -
K6J80_RS14875 223081..223614 - 534 WP_000118351.1 GNAT family N-acetyltransferase -
K6J80_RS18940 223611..223880 - 270 WP_000179600.1 DUF1778 domain-containing protein -
K6J80_RS14885 224103..224474 - 372 WP_001164080.1 MazG nucleotide pyrophosphohydrolase domain-containing protein -
K6J80_RS14890 224615..224902 - 288 WP_000426470.1 hypothetical protein -
K6J80_RS14895 225054..225722 - 669 WP_000043871.1 hypothetical protein -
K6J80_RS18945 225739..225801 - 63 Protein_206 acetyltransferase -
K6J80_RS14900 225953..226225 + 273 WP_000246253.1 DUF1778 domain-containing protein Antitoxin
K6J80_RS14905 226222..226719 + 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
K6J80_RS18950 226736..226804 - 69 Protein_209 acetyltransferase -
K6J80_RS14910 226921..227025 - 105 WP_228840819.1 DUF645 family protein -
K6J80_RS18955 227216..227338 - 123 Protein_211 acetyltransferase -
K6J80_RS14915 227395..227850 - 456 WP_001245327.1 GNAT family N-acetyltransferase -
K6J80_RS14920 227978..228265 - 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -
K6J80_RS14925 228255..228506 - 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
K6J80_RS14930 228720..229133 - 414 WP_000049417.1 VOC family protein -
K6J80_RS18960 229208..229318 - 111 WP_082798255.1 DUF3265 domain-containing protein -
K6J80_RS14935 229321..229722 - 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
K6J80_RS18965 229722..229892 - 171 WP_001080654.1 hypothetical protein -
K6J80_RS18970 230016..230414 - 399 Protein_219 GNAT family N-acetyltransferase -
K6J80_RS14945 230551..230857 - 307 Protein_220 CatB-related O-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 213119..319686 106567
inside Integron - - 213119..312856 99737
flank IS/Tn - - 230925..231905 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T38672 WP_000982260.1 NZ_AP024554:226222-226719 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T38672 NZ_AP024554:226222-226719 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT38672 WP_000246253.1 NZ_AP024554:225953-226225 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT38672 NZ_AP024554:225953-226225 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2IC79

References