88993

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 363565..364143 Replicon chromosome
Accession NZ_CP024868
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag VCA1552_RS16190 Protein ID WP_001180243.1
Coordinates 363565..363882 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag VCA1552_RS16195 Protein ID WP_000557292.1
Coordinates 363901..364143 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VCA1552_RS16140 358756..359151 + 396 WP_000046952.1 hypothetical protein -
VCA1552_RS16145 359454..359635 + 182 Protein_346 DUF645 family protein -
VCA1552_RS16150 359812..360207 + 396 WP_000046953.1 hypothetical protein -
VCA1552_RS16155 360351..360887 + 537 WP_000644491.1 nucleotidyltransferase family protein -
VCA1552_RS16160 361184..361363 + 180 WP_001883039.1 DUF645 family protein -
VCA1552_RS16165 361559..361984 + 426 WP_000403014.1 GNAT family N-acetyltransferase -
VCA1552_RS16170 362133..362480 + 348 WP_000933409.1 hypothetical protein -
VCA1552_RS19855 362627..362920 + 294 WP_125460920.1 hypothetical protein -
VCA1552_RS20000 363276..363371 + 96 WP_001907607.1 DUF645 family protein -
VCA1552_RS16190 363565..363882 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
VCA1552_RS16195 363901..364143 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
VCA1552_RS16200 364385..364894 + 510 WP_000405987.1 GNAT family N-acetyltransferase -
VCA1552_RS16205 364951..365604 + 654 WP_000226874.1 hypothetical protein -
VCA1552_RS16210 365914..366132 + 219 WP_001917086.1 DUF3709 domain-containing protein -
VCA1552_RS16215 366535..366768 + 234 WP_032482776.1 DUF3709 domain-containing protein -
VCA1552_RS16220 367193..367373 + 181 Protein_360 DUF645 family protein -
VCA1552_RS16230 367640..367927 + 288 WP_001162670.1 type II toxin-antitoxin system RelE/ParE family toxin -
VCA1552_RS16235 367938..368255 + 318 WP_001232701.1 HigA family addiction module antidote protein -
VCA1552_RS20005 368252..368362 + 111 WP_134814058.1 DUF3265 domain-containing protein -
VCA1552_RS16250 368539..368664 + 126 WP_001944767.1 DUF645 family protein -
VCA1552_RS16255 368680..368718 + 39 WP_106019119.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304717..433978 129261
inside Integron - - 309797..433602 123805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T88993 WP_001180243.1 NZ_CP024868:c363882-363565 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T88993 NZ_CP024868:c363882-363565 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT88993 WP_000557292.1 NZ_CP024868:c364143-363901 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT88993 NZ_CP024868:c364143-363901 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References