Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 363565..364143 Replicon chromosome
Accession NZ_CP024868
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag VCA1552_RS16190 Protein ID WP_001180243.1
Coordinates 363565..363882 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag VCA1552_RS16195 Protein ID WP_000557292.1
Coordinates 363901..364143 (-) Length 81 a.a.

Genomic Context

VCA1552_RS16140VCA1552_RS16145VCA1552_RS16150VCA1552_RS16155VCA1552_RS16160VCA1552_RS16165VCA1552_RS16170VCA1552_RS19855VCA1552_RS20000VCA1552_RS16200VCA1552_RS16205VCA1552_RS16210VCA1552_RS16215VCA1552_RS16220VCA1552_RS16230VCA1552_RS16235VCA1552_RS20005VCA1552_RS16250VCA1552_RS16255VCA1552_RS16190VCA1552_RS16195
Location: 358756..359151 (396 bp)
Type: Others
Protein ID: WP_000046952.1
Location: 359454..359635 (182 bp)
Type: Others
Protein ID: Protein_346
Location: 359812..360207 (396 bp)
Type: Others
Protein ID: WP_000046953.1
Location: 360351..360887 (537 bp)
Type: Others
Protein ID: WP_000644491.1
Location: 361184..361363 (180 bp)
Type: Others
Protein ID: WP_001883039.1
Location: 361559..361984 (426 bp)
Type: Others
Protein ID: WP_000403014.1
Location: 362133..362480 (348 bp)
Type: Others
Protein ID: WP_000933409.1
Location: 362627..362920 (294 bp)
Type: Others
Protein ID: WP_125460920.1
Location: 363276..363371 (96 bp)
Type: Others
Protein ID: WP_001907607.1
Location: 364385..364894 (510 bp)
Type: Others
Protein ID: WP_000405987.1
Location: 364951..365604 (654 bp)
Type: Others
Protein ID: WP_000226874.1
Location: 365914..366132 (219 bp)
Type: Others
Protein ID: WP_001917086.1
Location: 366535..366768 (234 bp)
Type: Others
Protein ID: WP_032482776.1
Location: 367193..367373 (181 bp)
Type: Others
Protein ID: Protein_360
Location: 367640..367927 (288 bp)
Type: Others
Protein ID: WP_001162670.1
Location: 367938..368255 (318 bp)
Type: Others
Protein ID: WP_001232701.1
Location: 368252..368362 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 368539..368664 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 368680..368718 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 363565..363882 (318 bp)
Type: Toxin
Protein ID: WP_001180243.1
Location: 363901..364143 (243 bp)
Type: Antitoxin
Protein ID: WP_000557292.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
VCA1552_RS16140358756..359151+396WP_000046952.1hypothetical protein-
VCA1552_RS16145359454..359635+182Protein_346DUF645 family protein-
VCA1552_RS16150359812..360207+396WP_000046953.1hypothetical protein-
VCA1552_RS16155360351..360887+537WP_000644491.1nucleotidyltransferase family protein-
VCA1552_RS16160361184..361363+180WP_001883039.1DUF645 family protein-
VCA1552_RS16165361559..361984+426WP_000403014.1GNAT family N-acetyltransferase-
VCA1552_RS16170362133..362480+348WP_000933409.1hypothetical protein-
VCA1552_RS19855362627..362920+294WP_125460920.1hypothetical protein-
VCA1552_RS20000363276..363371+96WP_001907607.1DUF645 family protein-
VCA1552_RS16190363565..363882-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxinToxin
VCA1552_RS16195363901..364143-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
VCA1552_RS16200364385..364894+510WP_000405987.1GNAT family N-acetyltransferase-
VCA1552_RS16205364951..365604+654WP_000226874.1hypothetical protein-
VCA1552_RS16210365914..366132+219WP_001917086.1DUF3709 domain-containing protein-
VCA1552_RS16215366535..366768+234WP_032482776.1DUF3709 domain-containing protein-
VCA1552_RS16220367193..367373+181Protein_360DUF645 family protein-
VCA1552_RS16230367640..367927+288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxin-
VCA1552_RS16235367938..368255+318WP_001232701.1HigA family addiction module antidote protein-
VCA1552_RS20005368252..368362+111WP_134814058.1DUF3265 domain-containing protein-
VCA1552_RS16250368539..368664+126WP_001944767.1DUF645 family protein-
VCA1552_RS16255368680..368718+39WP_106019119.1hypothetical protein-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304717..433978129261
insideIntegron--309797..433602123805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T88993 WP_001180243.1 NZ_CP024868:c363882-363565 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T88993 NZ_CP024868:c363882-363565 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT88993 WP_000557292.1 NZ_CP024868:c364143-363901 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT88993 NZ_CP024868:c364143-363901 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A0K9UJR8

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBQ7DCR7

References