Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 372121..372699 Replicon chromosome
Accession NZ_CP013318
Organism Vibrio cholerae strain NCTC5395

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag ASZ85_RS15950 Protein ID WP_001180243.1
Coordinates 372121..372438 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag ASZ85_RS15955 Protein ID WP_000557292.1
Coordinates 372457..372699 (-) Length 81 a.a.

Genomic Context

ASZ85_RS15920ASZ85_RS15925ASZ85_RS15930ASZ85_RS15935ASZ85_RS15940ASZ85_RS15945ASZ85_RS15960ASZ85_RS15965ASZ85_RS15970ASZ85_RS15980ASZ85_RS15985ASZ85_RS20980ASZ85_RS20985ASZ85_RS16005ASZ85_RS15950ASZ85_RS15955ASZ85_RS15990ASZ85_RS15995
Location: 367645..367827 (183 bp)
Type: Others
Protein ID: WP_000923340.1
Location: 368181..368363 (183 bp)
Type: Others
Protein ID: WP_000923153.1
Location: 368558..369235 (678 bp)
Type: Others
Protein ID: WP_000254617.1
Location: 369397..370605 (1209 bp)
Type: Others
Protein ID: WP_001900186.1
Location: 370767..371471 (705 bp)
Type: Others
Protein ID: WP_000087610.1
Location: 371629..371967 (339 bp)
Type: Others
Protein ID: WP_000713853.1
Location: 372943..373329 (387 bp)
Type: Others
Protein ID: WP_001015867.1
Location: 373386..373499 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 373448..373729 (282 bp)
Type: Others
Protein ID: WP_001894429.1
Location: 373987..374523 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 374660..375175 (516 bp)
Type: Others
Protein ID: WP_001201509.1
Location: 376484..376609 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 376625..376663 (39 bp)
Type: Others
Protein ID: WP_106019118.1
Location: 376859..377305 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 372121..372438 (318 bp)
Type: Toxin
Protein ID: WP_001180243.1
Location: 372457..372699 (243 bp)
Type: Antitoxin
Protein ID: WP_000557292.1
Location: 375325..375822 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 375819..376091 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ85_RS15920367645..367827+183WP_000923340.1DUF645 family protein-
ASZ85_RS15925368181..368363+183WP_000923153.1DUF645 family protein-
ASZ85_RS15930368558..369235+678WP_000254617.1HNH endonuclease-
ASZ85_RS15935369397..370605+1209WP_001900186.1deoxyguanosinetriphosphate triphosphohydrolase family protein-
ASZ85_RS15940370767..371471+705WP_000087610.1HNH endonuclease-
ASZ85_RS15945371629..371967+339WP_000713853.1hypothetical protein-
ASZ85_RS15950372121..372438-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxinToxin
ASZ85_RS15955372457..372699-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
ASZ85_RS15960372943..373329+387WP_001015867.1NUDIX hydrolase-
ASZ85_RS15965373386..373499+114WP_001900214.1hypothetical protein-
ASZ85_RS15970373448..373729+282WP_001894429.1DUF1289 domain-containing protein-
ASZ85_RS15980373987..374523+537WP_000469482.1GNAT family N-acetyltransferase-
ASZ85_RS15985374660..375175+516WP_001201509.1lipocalin family protein-
ASZ85_RS15990375325..375822-498WP_000982260.1GNAT family N-acetyltransferase-
ASZ85_RS15995375819..376091-273WP_000246253.1DUF1778 domain-containing protein-
ASZ85_RS20980376484..376609+126WP_001900195.1DUF645 family protein-
ASZ85_RS20985376625..376663+39WP_106019118.1hypothetical protein-
ASZ85_RS16005376859..377305+447WP_000006157.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--338285..496833158548
insideIntegron--343365..496457153092


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T58393 WP_001180243.1 NZ_CP013318:c372438-372121 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T58393 NZ_CP013318:c372438-372121 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT58393 WP_000557292.1 NZ_CP013318:c372699-372457 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT58393 NZ_CP013318:c372699-372457 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0K9UJR8

Antitoxin

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Source
ID
Structure
AlphaFold DBQ7DCR7

References