Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 340580..341118 | Replicon | chromosome |
| Accession | NZ_CP072850 | ||
| Organism | Vibrio cholerae MO10 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | Q9KMJ0 |
| Locus tag | KAF59_RS15425 | Protein ID | WP_000802136.1 |
| Coordinates | 340580..340879 (-) | Length | 100 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P58093 |
| Locus tag | KAF59_RS15430 | Protein ID | WP_001107719.1 |
| Coordinates | 340876..341118 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KAF59_RS18835 | 336220..336336 | + | 117 | WP_086010881.1 | DUF3265 domain-containing protein | - |
| KAF59_RS15380 (KAF59_15380) | 336326..336454 | + | 129 | WP_071908338.1 | general secretion pathway protein GspI | - |
| KAF59_RS15385 (KAF59_15385) | 336515..336697 | + | 183 | WP_000923182.1 | DUF645 family protein | - |
| KAF59_RS15390 (KAF59_15390) | 336897..337370 | + | 474 | WP_001161076.1 | GrpB family protein | - |
| KAF59_RS15395 (KAF59_15395) | 337385..337477 | + | 93 | WP_014378730.1 | DUF3265 domain-containing protein | - |
| KAF59_RS15400 (KAF59_15400) | 337519..338145 | + | 627 | WP_000365424.1 | LysE family translocator | - |
| KAF59_RS15405 (KAF59_15405) | 338268..338966 | + | 699 | WP_001890502.1 | hypothetical protein | - |
| KAF59_RS15410 (KAF59_15410) | 338997..339086 | + | 90 | WP_072606010.1 | DUF3265 domain-containing protein | - |
| KAF59_RS15415 (KAF59_15415) | 339664..339843 | + | 180 | WP_001883058.1 | DUF645 family protein | - |
| KAF59_RS15420 (KAF59_15420) | 340057..340452 | + | 396 | WP_000870857.1 | DUF3465 domain-containing protein | - |
| KAF59_RS15425 (KAF59_15425) | 340580..340879 | - | 300 | WP_000802136.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| KAF59_RS15430 (KAF59_15430) | 340876..341118 | - | 243 | WP_001107719.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| KAF59_RS15435 (KAF59_15435) | 341347..341925 | + | 579 | WP_000110120.1 | hypothetical protein | - |
| KAF59_RS15440 (KAF59_15440) | 341947..342039 | + | 93 | WP_014164112.1 | DUF3265 domain-containing protein | - |
| KAF59_RS15445 (KAF59_15445) | 342463..343146 | + | 684 | WP_000877436.1 | hypothetical protein | - |
| KAF59_RS15450 (KAF59_15450) | 343360..343626 | + | 267 | WP_000937852.1 | hypothetical protein | - |
| KAF59_RS15455 (KAF59_15455) | 343781..344380 | + | 600 | WP_000429495.1 | DUF6338 family protein | - |
| KAF59_RS15460 (KAF59_15460) | 344661..345596 | + | 936 | WP_000051985.1 | restriction endonuclease | - |
| KAF59_RS15465 (KAF59_15465) | 345562..345702 | + | 141 | WP_001883049.1 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | catB9 | - | 306928..402189 | 95261 | |
| inside | Integron | catB9 | - | 312008..401813 | 89805 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 100 a.a. Molecular weight: 11589.29 Da Isoelectric Point: 9.9232
>T199002 WP_000802136.1 NZ_CP072850:c340879-340580 [Vibrio cholerae MO10]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA
Download Length: 300 bp
>T199002 NZ_CP097083:169683-170165 [Klebsiella pneumoniae]
GTGGGACGTATAACCGCGCCCGAGCCGTTATCCAGCGCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCACTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGAAGGGTACGA
AGAAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCTACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGTGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGCGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA
GTGGGACGTATAACCGCGCCCGAGCCGTTATCCAGCGCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCACTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGAAGGGTACGA
AGAAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCTACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGTGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGCGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8964.84 Da Isoelectric Point: 4.1677
>AT199002 WP_001107719.1 NZ_CP072850:c341118-340876 [Vibrio cholerae MO10]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR
Download Length: 243 bp
>AT199002 NZ_CP097083:169429-169695 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGTACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGATTCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGTACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGATTCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|