Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 442434..443200 Replicon chromosome
Accession NZ_OW443148
Organism Vibrio cholerae strain CNRVC190243 isolate YE-NCPHL-19014-PI

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag OC617_RS16260 Protein ID WP_000982260.1
Coordinates 442434..442931 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag OC617_RS16265 Protein ID WP_000246253.1
Coordinates 442928..443200 (-) Length 91 a.a.

Genomic Context

OC617_RS16200OC617_RS16205OC617_RS16210OC617_RS16215OC617_RS16220OC617_RS16225OC617_RS16230OC617_RS16235OC617_RS16240OC617_RS16245OC617_RS16250OC617_RS16255OC617_RS16270OC617_RS16275OC617_RS16280OC617_RS16285OC617_RS16290OC617_RS16295OC617_RS16300OC617_RS16305OC617_RS16310OC617_RS16315OC617_RS16260OC617_RS16265
Location: 438296..438602 (307 bp)
Type: Others
Protein ID: Protein_462
Location: 438739..439137 (399 bp)
Type: Others
Protein ID: Protein_463
Location: 439261..439431 (171 bp)
Type: Others
Protein ID: WP_001080654.1
Location: 439431..439832 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 439835..439945 (111 bp)
Type: Others
Protein ID: WP_082798255.1
Location: 440020..440433 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 440647..440898 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 440888..441175 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 441303..441758 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 441815..441937 (123 bp)
Type: Others
Protein ID: Protein_471
Location: 442108..442232 (125 bp)
Type: Others
Protein ID: Protein_472
Location: 442349..442417 (69 bp)
Type: Others
Protein ID: Protein_473
Location: 443352..443414 (63 bp)
Type: Others
Protein ID: Protein_476
Location: 443431..444099 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 444251..444538 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 444679..445050 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 445273..445542 (270 bp)
Type: Others
Protein ID: WP_000179600.1
Location: 445539..446072 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 446082..446192 (111 bp)
Type: Others
Protein ID: WP_086010065.1
Location: 446274..446531 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 446519..446821 (303 bp)
Type: Others
Protein ID: WP_000229317.1
Location: 447055..447972 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 442434..442931 (498 bp)
Type: Toxin
Protein ID: WP_000982260.1
Location: 442928..443200 (273 bp)
Type: Antitoxin
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
OC617_RS16200 (CNRVC190243H_03177)438296..438602+307Protein_462CatB-related O-acetyltransferase-
OC617_RS16205438739..439137+399Protein_463GNAT family N-acetyltransferase-
OC617_RS16210439261..439431+171WP_001080654.1hypothetical protein-
OC617_RS16215 (CNRVC190243H_03179)439431..439832+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
OC617_RS16220439835..439945+111WP_082798255.1DUF3265 domain-containing protein-
OC617_RS16225 (CNRVC190243H_03180)440020..440433+414WP_000049417.1VOC family protein-
OC617_RS16230 (CNRVC190243H_03181)440647..440898+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
OC617_RS16235 (CNRVC190243H_03182)440888..441175+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
OC617_RS16240 (CNRVC190243H_03183)441303..441758+456WP_001245327.1GNAT family N-acetyltransferase-
OC617_RS16245441815..441937+123Protein_471acetyltransferase-
OC617_RS16250442108..442232+125Protein_472DUF645 family protein-
OC617_RS16255442349..442417+69Protein_473acetyltransferase-
OC617_RS16260 (CNRVC190243H_03184)442434..442931-498WP_000982260.1GNAT family N-acetyltransferaseToxin
OC617_RS16265 (CNRVC190243H_03185)442928..443200-273WP_000246253.1DUF1778 domain-containing proteinAntitoxin
OC617_RS16270443352..443414+63Protein_476acetyltransferase-
OC617_RS16275 (CNRVC190243H_03186)443431..444099+669WP_000043871.1hypothetical protein-
OC617_RS16280 (CNRVC190243H_03187)444251..444538+288WP_000426470.1hypothetical protein-
OC617_RS16285 (CNRVC190243H_03188)444679..445050+372WP_001164080.1MazG nucleotide pyrophosphohydrolase domain-containing protein-
OC617_RS16290 (CNRVC190243H_03189)445273..445542+270WP_000179600.1DUF1778 domain-containing protein-
OC617_RS16295 (CNRVC190243H_03190)445539..446072+534WP_000118351.1GNAT family N-acetyltransferase-
OC617_RS16300446082..446192+111WP_086010065.1DUF3265 domain-containing protein-
OC617_RS16305 (CNRVC190243H_03191)446274..446531+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
OC617_RS16310 (CNRVC190243H_03192)446519..446821+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxin-
OC617_RS16315 (CNRVC190243H_03193)447055..447972+918WP_000186333.1alpha/beta hydrolase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-349905..456410106505
insideIntegroncatB9-354985..456034101049
flankIS/Tn--437248..438228980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T295398 WP_000982260.1 NZ_OW443148:c442931-442434 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT295398 WP_000246253.1 NZ_OW443148:c443200-442928 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0KGB1

Antitoxin

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Source
ID
Structure
PDB1Y9B
AlphaFold DBA0A0F2IC79

References