Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-GNAT
Location 914103..915196 Replicon chromosome
Accession NZ_LT992487
Organism Vibrio cholerae strain 4295STDY6534216

Toxin (Protein)


Gene name doc Uniprot ID Q9KMA2
Locus tag DG247_RS18500 Protein ID WP_000351248.1
Coordinates 914103..914504 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag DG247_RS18505 Protein ID WP_001047169.1
Coordinates 914504..915196 (-) Length 231 a.a.

Genomic Context

DG247_RS18455DG247_RS18460DG247_RS18515DG247_RS18445DG247_RS18450DG247_RS18470DG247_RS18475DG247_RS18480DG247_RS18485DG247_RS18490DG247_RS18495DG247_RS18500DG247_RS18505DG247_RS18510DG247_RS19670DG247_RS18520DG247_RS18525DG247_RS18530DG247_RS18540DG247_RS19800DG247_RS18560DG247_RS19805DG247_RS18565
Location: 910735..911007 (273 bp)
Type: Others
Protein ID: WP_000246253.1
Location: 911004..911501 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 915707..916687 (981 bp)
Type: Others
Protein ID: WP_000019370.1
Location: 909397..909684 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 909836..910504 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 911703..911855 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 912177..912632 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 912760..913047 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 913037..913288 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 913502..913915 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 913990..914133 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 914103..914504 (402 bp)
Type: Toxin
Protein ID: WP_000351248.1
Location: 914504..915196 (693 bp)
Type: Antitoxin
Protein ID: WP_001047169.1
Location: 915333..915639 (307 bp)
Type: Others
Protein ID: Protein_787
Location: 916812..916967 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 917135..917569 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 917706..918020 (315 bp)
Type: Others
Protein ID: WP_000071008.1
Location: 918007..918339 (333 bp)
Type: Others
Protein ID: WP_000843587.1
Location: 918680..918907 (228 bp)
Type: Others
Protein ID: WP_001894457.1
Location: 918856..918969 (114 bp)
Type: Others
Protein ID: WP_001889158.1
Location: 919135..919416 (282 bp)
Type: Others
Protein ID: WP_001894453.1
Location: 919365..919479 (115 bp)
Type: Others
Protein ID: Protein_796
Location: 919536..919913 (378 bp)
Type: Others
Protein ID: WP_000411109.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DG247_RS18445909397..909684-288WP_000426470.1hypothetical protein-
DG247_RS18450909836..910504-669WP_000043871.1hypothetical protein-
DG247_RS18455910735..911007+273WP_000246253.1DUF1778 domain-containing protein-
DG247_RS18460911004..911501+498WP_000982260.1GNAT family N-acetyltransferase-
DG247_RS18470911703..911855-153WP_001884520.1DUF645 family protein-
DG247_RS18475912177..912632-456WP_001245327.1GNAT family N-acetyltransferase-
DG247_RS18480912760..913047-288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
DG247_RS18485913037..913288-252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
DG247_RS18490913502..913915-414WP_000049417.1VOC family protein-
DG247_RS18495913990..914133-144WP_071908341.1DUF3265 domain-containing protein-
DG247_RS18500914103..914504-402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxinToxin
DG247_RS18505914504..915196-693WP_001047169.1GNAT family N-acetyltransferaseAntitoxin
DG247_RS18510915333..915639-307Protein_787CatB-related O-acetyltransferase-
DG247_RS18515915707..916687+981WP_000019370.1IS5-like element ISVch5 family transposase-
DG247_RS19670916812..916967-156WP_000751734.1hypothetical protein-
DG247_RS18520917135..917569-435WP_000256036.1GNAT family N-acetyltransferase-
DG247_RS18525917706..918020-315WP_000071008.1DNA-binding transcriptional regulator-
DG247_RS18530918007..918339-333WP_000843587.1type II toxin-antitoxin system RelE/ParE family toxin-
DG247_RS18540918680..918907-228WP_001894457.1DUF1289 domain-containing protein-
DG247_RS19800918856..918969-114WP_001889158.1hypothetical protein-
DG247_RS18560919135..919416-282WP_001894453.1DUF1289 domain-containing protein-
DG247_RS19805919365..919479-115Protein_796acetyltransferase-
DG247_RS18565919536..919913-378WP_000411109.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-897525..99449796972
insideIntegroncatB9-897901..98770989808
flankIS/Tn--915707..916687980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-132)

Antitoxin

GNAT domain

(36-153)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14608.71 Da        Isoelectric Point: 4.0128

>T294355 WP_000351248.1 NZ_LT992487:c914504-914103 [Vibrio cholerae]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL

Download         Length: 402 bp

Antitoxin


Download         Length: 231 a.a.        Molecular weight: 26352.73 Da        Isoelectric Point: 8.5633

>AT294355 WP_001047169.1 NZ_LT992487:c915196-914504 [Vibrio cholerae]
MNLEEFQESDFDLLIKWIDSDELNYLWGCPAYVFPLTYEQIHSHCSKAEVFPYLLKVKGRHAGFVELYKVTDEQYRICRV
FISNAYRGQGLSKSMLMLLIDKARLDFSATKLSLGVFEQNTVARKCYESLGFEVVMVVVIEFGGMRCQPLRRALCFLSRF
GAIIGLTFIDSRCDMNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM

Download         Length: 693 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0PN34

Antitoxin

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Source
ID
Structure
No matching records found

References