145883

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 323672..324250 Replicon chromosome
Accession NZ_CP047304
Organism Vibrio cholerae O1 biovar El Tor strain E7946

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag GTF74_RS15160 Protein ID WP_001180243.1
Coordinates 323672..323989 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag GTF74_RS15165 Protein ID WP_000557292.1
Coordinates 324008..324250 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTF74_RS15130 319196..319378 + 183 WP_000923340.1 DUF645 family protein -
GTF74_RS15135 319732..319914 + 183 WP_000923153.1 DUF645 family protein -
GTF74_RS15140 320109..320786 + 678 WP_000254617.1 HNH endonuclease -
GTF74_RS15145 320948..322156 + 1209 WP_000272282.1 deoxyguanosinetriphosphate triphosphohydrolase family protein -
GTF74_RS15150 322318..323022 + 705 WP_000087610.1 HNH endonuclease -
GTF74_RS15155 323180..323518 + 339 WP_000713853.1 hypothetical protein -
GTF74_RS15160 323672..323989 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GTF74_RS15165 324008..324250 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GTF74_RS15170 324494..324880 + 387 WP_001015867.1 NUDIX hydrolase -
GTF74_RS15175 324937..325050 + 114 WP_001900214.1 hypothetical protein -
GTF74_RS15180 324999..325280 + 282 WP_001894429.1 DUF1289 domain-containing protein -
GTF74_RS15185 325256..325414 - 159 WP_001886450.1 DUF1196 family protein -
GTF74_RS15190 325538..326074 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
GTF74_RS15195 326211..326726 + 516 WP_001201509.1 lipocalin family protein -
GTF74_RS15200 326876..327373 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
GTF74_RS15205 327370..327642 - 273 WP_000246253.1 DUF1778 domain-containing protein -
GTF74_RS15210 328035..328160 + 126 WP_001900195.1 DUF645 family protein -
GTF74_RS15215 328176..328214 + 39 WP_106019118.1 hypothetical protein -
GTF74_RS15220 328410..328856 + 447 WP_000006157.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 307032..436751 129719
inside Integron - - 312112..436375 124263


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T145883 WP_001180243.1 NZ_CP047304:c323989-323672 [Vibrio cholerae O1 biovar El Tor]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T145883 NZ_CP062705:4481575-4481835 [Escherichia coli O157:H7]
TTGAACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAATAAATTGAAATATCTTAT
GACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAGGTTCATGGAAAGGTTATC
GCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGATTTGAGAGAACTGGAACT
CACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT145883 WP_000557292.1 NZ_CP047304:c324250-324008 [Vibrio cholerae O1 biovar El Tor]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT145883 NZ_CP062705:4481296-4481556 [Escherichia coli O157:H7]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References