58222

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 376763..377322 Replicon chromosome
Accession NZ_CP013302
Organism Vibrio cholerae strain C5

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag ASZ80_RS16210 Protein ID WP_000578476.1
Coordinates 376763..377041 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag ASZ80_RS16215 Protein ID WP_000381183.1
Coordinates 377038..377322 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ80_RS16165 371841..372347 + 507 WP_000393074.1 hypothetical protein -
ASZ80_RS16170 372504..372890 + 387 WP_000703163.1 VOC family protein -
ASZ80_RS16175 373147..373350 + 204 WP_001911580.1 hypothetical protein -
ASZ80_RS16180 373545..373796 + 252 WP_001890111.1 TIGR03643 family protein -
ASZ80_RS16185 373769..373918 + 150 WP_071908333.1 DUF3265 domain-containing protein -
ASZ80_RS16190 374065..374490 + 426 WP_000415750.1 hypothetical protein -
ASZ80_RS16195 374696..375319 + 624 WP_000247070.1 DUF1349 domain-containing protein -
ASZ80_RS16200 375532..376011 + 480 WP_000009888.1 lecithin retinol acyltransferase family protein -
ASZ80_RS16205 376199..376612 + 414 WP_000049420.1 VOC family protein -
ASZ80_RS16210 376763..377041 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
ASZ80_RS16215 377038..377322 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
ASZ80_RS16225 377517..378032 + 516 WP_001201520.1 lipocalin family protein -
ASZ80_RS16230 378097..378693 + 597 WP_000255434.1 hypothetical protein -
ASZ80_RS16245 379085..379267 + 183 WP_000923182.1 DUF645 family protein -
ASZ80_RS16250 379467..379940 + 474 WP_001161076.1 GrpB family protein -
ASZ80_RS16255 379955..380047 + 93 WP_014378730.1 DUF3265 domain-containing protein -
ASZ80_RS16260 380089..380715 + 627 WP_000365424.1 LysE family translocator -
ASZ80_RS16265 380838..381536 + 699 WP_001890502.1 hypothetical protein -
ASZ80_RS16270 381546..381656 + 111 WP_079857360.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304694..469286 164592
inside Integron - - 309774..468910 159136


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T58222 WP_000578476.1 NZ_CP013302:c377041-376763 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T58222 NZ_CP013302:c377041-376763 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT58222 WP_000381183.1 NZ_CP013302:c377322-377038 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT58222 NZ_CP013302:c377322-377038 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9K2M8

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References