Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 376763..377322 Replicon chromosome
Accession NZ_CP013302
Organism Vibrio cholerae strain C5

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag ASZ80_RS16210 Protein ID WP_000578476.1
Coordinates 376763..377041 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag ASZ80_RS16215 Protein ID WP_000381183.1
Coordinates 377038..377322 (-) Length 95 a.a.

Genomic Context

ASZ80_RS16165ASZ80_RS16170ASZ80_RS16175ASZ80_RS16180ASZ80_RS16185ASZ80_RS16190ASZ80_RS16195ASZ80_RS16200ASZ80_RS16205ASZ80_RS16225ASZ80_RS16230ASZ80_RS16245ASZ80_RS16250ASZ80_RS16255ASZ80_RS16260ASZ80_RS16265ASZ80_RS16270ASZ80_RS16210ASZ80_RS16215
Location: 371841..372347 (507 bp)
Type: Others
Protein ID: WP_000393074.1
Location: 372504..372890 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 373147..373350 (204 bp)
Type: Others
Protein ID: WP_001911580.1
Location: 373545..373796 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 373769..373918 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 374065..374490 (426 bp)
Type: Others
Protein ID: WP_000415750.1
Location: 374696..375319 (624 bp)
Type: Others
Protein ID: WP_000247070.1
Location: 375532..376011 (480 bp)
Type: Others
Protein ID: WP_000009888.1
Location: 376199..376612 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 377517..378032 (516 bp)
Type: Others
Protein ID: WP_001201520.1
Location: 378097..378693 (597 bp)
Type: Others
Protein ID: WP_000255434.1
Location: 379085..379267 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 379467..379940 (474 bp)
Type: Others
Protein ID: WP_001161076.1
Location: 379955..380047 (93 bp)
Type: Others
Protein ID: WP_014378730.1
Location: 380089..380715 (627 bp)
Type: Others
Protein ID: WP_000365424.1
Location: 380838..381536 (699 bp)
Type: Others
Protein ID: WP_001890502.1
Location: 381546..381656 (111 bp)
Type: Others
Protein ID: WP_079857360.1
Location: 376763..377041 (279 bp)
Type: Toxin
Protein ID: WP_000578476.1
Location: 377038..377322 (285 bp)
Type: Antitoxin
Protein ID: WP_000381183.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ80_RS16165371841..372347+507WP_000393074.1hypothetical protein-
ASZ80_RS16170372504..372890+387WP_000703163.1VOC family protein-
ASZ80_RS16175373147..373350+204WP_001911580.1hypothetical protein-
ASZ80_RS16180373545..373796+252WP_001890111.1TIGR03643 family protein-
ASZ80_RS16185373769..373918+150WP_071908333.1DUF3265 domain-containing protein-
ASZ80_RS16190374065..374490+426WP_000415750.1hypothetical protein-
ASZ80_RS16195374696..375319+624WP_000247070.1DUF1349 domain-containing protein-
ASZ80_RS16200375532..376011+480WP_000009888.1lecithin retinol acyltransferase family protein-
ASZ80_RS16205376199..376612+414WP_000049420.1VOC family protein-
ASZ80_RS16210376763..377041-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
ASZ80_RS16215377038..377322-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
ASZ80_RS16225377517..378032+516WP_001201520.1lipocalin family protein-
ASZ80_RS16230378097..378693+597WP_000255434.1hypothetical protein-
ASZ80_RS16245379085..379267+183WP_000923182.1DUF645 family protein-
ASZ80_RS16250379467..379940+474WP_001161076.1GrpB family protein-
ASZ80_RS16255379955..380047+93WP_014378730.1DUF3265 domain-containing protein-
ASZ80_RS16260380089..380715+627WP_000365424.1LysE family translocator-
ASZ80_RS16265380838..381536+699WP_001890502.1hypothetical protein-
ASZ80_RS16270381546..381656+111WP_079857360.1DUF3265 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304694..469286164592
insideIntegron--309774..468910159136


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T58222 WP_000578476.1 NZ_CP013302:c377041-376763 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T58222 NZ_CP013302:c377041-376763 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT58222 WP_000381183.1 NZ_CP013302:c377322-377038 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT58222 NZ_CP013302:c377322-377038 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9K2M8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A067BL33

References