45808

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 365256..365834 Replicon chromosome
Accession NZ_CP006948
Organism Vibrio cholerae O1 str. KW3

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag N900_RS15795 Protein ID WP_001180243.1
Coordinates 365256..365573 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag N900_RS15800 Protein ID WP_000557292.1
Coordinates 365592..365834 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N900_RS15760 360448..360843 + 396 WP_000046952.1 hypothetical protein -
N900_RS19550 361146..361327 + 182 Protein_347 DUF645 family protein -
N900_RS15765 361504..361899 + 396 WP_000046953.1 hypothetical protein -
N900_RS15770 362043..362579 + 537 WP_000644491.1 nucleotidyltransferase family protein -
N900_RS15780 362876..363055 + 180 WP_001883039.1 DUF645 family protein -
N900_RS15785 363251..363676 + 426 WP_000403014.1 GNAT family N-acetyltransferase -
N900_RS15790 363825..364172 + 348 WP_000933409.1 hypothetical protein -
N900_RS20185 364319..364612 + 294 WP_125460920.1 hypothetical protein -
N900_RS20350 364967..365062 + 96 WP_001907607.1 DUF645 family protein -
N900_RS15795 365256..365573 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N900_RS15800 365592..365834 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
N900_RS15805 366076..366585 + 510 WP_000405987.1 GNAT family N-acetyltransferase -
N900_RS15810 366642..367295 + 654 WP_000226874.1 hypothetical protein -
N900_RS15815 367605..367823 + 219 WP_001917086.1 DUF3709 domain-containing protein -
N900_RS19580 368226..368459 + 234 WP_032482776.1 DUF3709 domain-containing protein -
N900_RS15820 368884..369064 + 181 Protein_361 DUF645 family protein -
N900_RS15825 369331..369618 + 288 WP_001162670.1 type II toxin-antitoxin system RelE/ParE family toxin -
N900_RS15830 369629..369946 + 318 WP_001232701.1 HigA family addiction module antidote protein -
N900_RS20355 369943..370053 + 111 WP_134814058.1 DUF3265 domain-containing protein -
N900_RS20360 370230..370355 + 126 WP_001944767.1 DUF645 family protein -
N900_RS20365 370371..370409 + 39 WP_106019119.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304645..411088 106443
inside Integron - - 309725..410760 101035


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T45808 WP_001180243.1 NZ_CP006948:c365573-365256 [Vibrio cholerae O1 str. KW3]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T45808 NZ_CP006948:c365573-365256 [Vibrio cholerae O1 str. KW3]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT45808 WP_000557292.1 NZ_CP006948:c365834-365592 [Vibrio cholerae O1 str. KW3]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT45808 NZ_CP006948:c365834-365592 [Vibrio cholerae O1 str. KW3]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References