Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 365256..365834 Replicon chromosome
Accession NZ_CP006948
Organism Vibrio cholerae O1 str. KW3

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag N900_RS15795 Protein ID WP_001180243.1
Coordinates 365256..365573 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag N900_RS15800 Protein ID WP_000557292.1
Coordinates 365592..365834 (-) Length 81 a.a.

Genomic Context

N900_RS15760N900_RS19550N900_RS15765N900_RS15770N900_RS15780N900_RS15785N900_RS15790N900_RS20185N900_RS20350N900_RS15805N900_RS15810N900_RS15815N900_RS19580N900_RS15820N900_RS15825N900_RS15830N900_RS20355N900_RS20360N900_RS20365N900_RS15795N900_RS15800
Location: 360448..360843 (396 bp)
Type: Others
Protein ID: WP_000046952.1
Location: 361146..361327 (182 bp)
Type: Others
Protein ID: Protein_347
Location: 361504..361899 (396 bp)
Type: Others
Protein ID: WP_000046953.1
Location: 362043..362579 (537 bp)
Type: Others
Protein ID: WP_000644491.1
Location: 362876..363055 (180 bp)
Type: Others
Protein ID: WP_001883039.1
Location: 363251..363676 (426 bp)
Type: Others
Protein ID: WP_000403014.1
Location: 363825..364172 (348 bp)
Type: Others
Protein ID: WP_000933409.1
Location: 364319..364612 (294 bp)
Type: Others
Protein ID: WP_125460920.1
Location: 364967..365062 (96 bp)
Type: Others
Protein ID: WP_001907607.1
Location: 366076..366585 (510 bp)
Type: Others
Protein ID: WP_000405987.1
Location: 366642..367295 (654 bp)
Type: Others
Protein ID: WP_000226874.1
Location: 367605..367823 (219 bp)
Type: Others
Protein ID: WP_001917086.1
Location: 368226..368459 (234 bp)
Type: Others
Protein ID: WP_032482776.1
Location: 368884..369064 (181 bp)
Type: Others
Protein ID: Protein_361
Location: 369331..369618 (288 bp)
Type: Others
Protein ID: WP_001162670.1
Location: 369629..369946 (318 bp)
Type: Others
Protein ID: WP_001232701.1
Location: 369943..370053 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 370230..370355 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 370371..370409 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 365256..365573 (318 bp)
Type: Toxin
Protein ID: WP_001180243.1
Location: 365592..365834 (243 bp)
Type: Antitoxin
Protein ID: WP_000557292.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
N900_RS15760360448..360843+396WP_000046952.1hypothetical protein-
N900_RS19550361146..361327+182Protein_347DUF645 family protein-
N900_RS15765361504..361899+396WP_000046953.1hypothetical protein-
N900_RS15770362043..362579+537WP_000644491.1nucleotidyltransferase family protein-
N900_RS15780362876..363055+180WP_001883039.1DUF645 family protein-
N900_RS15785363251..363676+426WP_000403014.1GNAT family N-acetyltransferase-
N900_RS15790363825..364172+348WP_000933409.1hypothetical protein-
N900_RS20185364319..364612+294WP_125460920.1hypothetical protein-
N900_RS20350364967..365062+96WP_001907607.1DUF645 family protein-
N900_RS15795365256..365573-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxinToxin
N900_RS15800365592..365834-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
N900_RS15805366076..366585+510WP_000405987.1GNAT family N-acetyltransferase-
N900_RS15810366642..367295+654WP_000226874.1hypothetical protein-
N900_RS15815367605..367823+219WP_001917086.1DUF3709 domain-containing protein-
N900_RS19580368226..368459+234WP_032482776.1DUF3709 domain-containing protein-
N900_RS15820368884..369064+181Protein_361DUF645 family protein-
N900_RS15825369331..369618+288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxin-
N900_RS15830369629..369946+318WP_001232701.1HigA family addiction module antidote protein-
N900_RS20355369943..370053+111WP_134814058.1DUF3265 domain-containing protein-
N900_RS20360370230..370355+126WP_001944767.1DUF645 family protein-
N900_RS20365370371..370409+39WP_106019119.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304645..411088106443
insideIntegron--309725..410760101035


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T45808 WP_001180243.1 NZ_CP006948:c365573-365256 [Vibrio cholerae O1 str. KW3]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T45808 NZ_CP006948:c365573-365256 [Vibrio cholerae O1 str. KW3]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT45808 WP_000557292.1 NZ_CP006948:c365834-365592 [Vibrio cholerae O1 str. KW3]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT45808 NZ_CP006948:c365834-365592 [Vibrio cholerae O1 str. KW3]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0K9UJR8

Antitoxin

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Source
ID
Structure
AlphaFold DBQ7DCR7

References