Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 90349..90927 Replicon chromosome
Accession NZ_CP026648
Organism Vibrio cholerae O1 biovar El Tor strain HC1037

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag C4E16_RS14855 Protein ID WP_001180243.1
Coordinates 90349..90666 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag C4E16_RS14860 Protein ID WP_000557292.1
Coordinates 90685..90927 (-) Length 81 a.a.

Genomic Context

C4E16_RS14805C4E16_RS14810C4E16_RS14815C4E16_RS14820C4E16_RS14825C4E16_RS14830C4E16_RS14835C4E16_RS19435C4E16_RS19565C4E16_RS14865C4E16_RS14870C4E16_RS14875C4E16_RS14880C4E16_RS14885C4E16_RS14895C4E16_RS14900C4E16_RS19570C4E16_RS14915C4E16_RS19440C4E16_RS14855C4E16_RS14860
Location: 85540..85935 (396 bp)
Type: Others
Protein ID: WP_000046952.1
Location: 86238..86419 (182 bp)
Type: Others
Protein ID: Protein_125
Location: 86596..86991 (396 bp)
Type: Others
Protein ID: WP_000046953.1
Location: 87135..87671 (537 bp)
Type: Others
Protein ID: WP_000644491.1
Location: 87968..88147 (180 bp)
Type: Others
Protein ID: WP_001883039.1
Location: 88343..88768 (426 bp)
Type: Others
Protein ID: WP_000403014.1
Location: 88917..89264 (348 bp)
Type: Others
Protein ID: WP_000933409.1
Location: 89411..89704 (294 bp)
Type: Others
Protein ID: WP_125460920.1
Location: 90060..90155 (96 bp)
Type: Others
Protein ID: WP_001907607.1
Location: 91169..91678 (510 bp)
Type: Others
Protein ID: WP_000405987.1
Location: 91735..92388 (654 bp)
Type: Others
Protein ID: WP_000226874.1
Location: 92698..92916 (219 bp)
Type: Others
Protein ID: WP_001917086.1
Location: 93319..93552 (234 bp)
Type: Others
Protein ID: WP_032482776.1
Location: 93977..94157 (181 bp)
Type: Others
Protein ID: Protein_139
Location: 94424..94711 (288 bp)
Type: Others
Protein ID: WP_001162670.1
Location: 94722..95039 (318 bp)
Type: Others
Protein ID: WP_001232701.1
Location: 95036..95146 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 95323..95448 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 95464..95502 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 90349..90666 (318 bp)
Type: Toxin
Protein ID: WP_001180243.1
Location: 90685..90927 (243 bp)
Type: Antitoxin
Protein ID: WP_000557292.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
C4E16_RS1480585540..85935+396WP_000046952.1hypothetical protein-
C4E16_RS1481086238..86419+182Protein_125DUF645 family protein-
C4E16_RS1481586596..86991+396WP_000046953.1hypothetical protein-
C4E16_RS1482087135..87671+537WP_000644491.1nucleotidyltransferase family protein-
C4E16_RS1482587968..88147+180WP_001883039.1DUF645 family protein-
C4E16_RS1483088343..88768+426WP_000403014.1GNAT family N-acetyltransferase-
C4E16_RS1483588917..89264+348WP_000933409.1hypothetical protein-
C4E16_RS1943589411..89704+294WP_125460920.1hypothetical protein-
C4E16_RS1956590060..90155+96WP_001907607.1DUF645 family protein-
C4E16_RS1485590349..90666-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxinToxin
C4E16_RS1486090685..90927-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
C4E16_RS1486591169..91678+510WP_000405987.1GNAT family N-acetyltransferase-
C4E16_RS1487091735..92388+654WP_000226874.1hypothetical protein-
C4E16_RS1487592698..92916+219WP_001917086.1DUF3709 domain-containing protein-
C4E16_RS1488093319..93552+234WP_032482776.1DUF3709 domain-containing protein-
C4E16_RS1488593977..94157+181Protein_139DUF645 family protein-
C4E16_RS1489594424..94711+288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxin-
C4E16_RS1490094722..95039+318WP_001232701.1HigA family addiction module antidote protein-
C4E16_RS1957095036..95146+111WP_134814058.1DUF3265 domain-containing protein-
C4E16_RS1491595323..95448+126WP_001944767.1DUF645 family protein-
C4E16_RS1944095464..95502+39WP_106019119.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-31043..136234105191
insideIntegron--36123..13585899735


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T95381 WP_001180243.1 NZ_CP026648:c90666-90349 [Vibrio cholerae O1 biovar El Tor]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T95381 NZ_CP026648:c90666-90349 [Vibrio cholerae O1 biovar El Tor]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT95381 WP_000557292.1 NZ_CP026648:c90927-90685 [Vibrio cholerae O1 biovar El Tor]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT95381 NZ_CP026648:c90927-90685 [Vibrio cholerae O1 biovar El Tor]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0K9UJR8

Antitoxin

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Source
ID
Structure
AlphaFold DBQ7DCR7

References