95381

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 90349..90927 Replicon chromosome
Accession NZ_CP026648
Organism Vibrio cholerae O1 biovar El Tor strain HC1037

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag C4E16_RS14855 Protein ID WP_001180243.1
Coordinates 90349..90666 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag C4E16_RS14860 Protein ID WP_000557292.1
Coordinates 90685..90927 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4E16_RS14805 85540..85935 + 396 WP_000046952.1 hypothetical protein -
C4E16_RS14810 86238..86419 + 182 Protein_125 DUF645 family protein -
C4E16_RS14815 86596..86991 + 396 WP_000046953.1 hypothetical protein -
C4E16_RS14820 87135..87671 + 537 WP_000644491.1 nucleotidyltransferase family protein -
C4E16_RS14825 87968..88147 + 180 WP_001883039.1 DUF645 family protein -
C4E16_RS14830 88343..88768 + 426 WP_000403014.1 GNAT family N-acetyltransferase -
C4E16_RS14835 88917..89264 + 348 WP_000933409.1 hypothetical protein -
C4E16_RS19435 89411..89704 + 294 WP_125460920.1 hypothetical protein -
C4E16_RS19565 90060..90155 + 96 WP_001907607.1 DUF645 family protein -
C4E16_RS14855 90349..90666 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C4E16_RS14860 90685..90927 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
C4E16_RS14865 91169..91678 + 510 WP_000405987.1 GNAT family N-acetyltransferase -
C4E16_RS14870 91735..92388 + 654 WP_000226874.1 hypothetical protein -
C4E16_RS14875 92698..92916 + 219 WP_001917086.1 DUF3709 domain-containing protein -
C4E16_RS14880 93319..93552 + 234 WP_032482776.1 DUF3709 domain-containing protein -
C4E16_RS14885 93977..94157 + 181 Protein_139 DUF645 family protein -
C4E16_RS14895 94424..94711 + 288 WP_001162670.1 type II toxin-antitoxin system RelE/ParE family toxin -
C4E16_RS14900 94722..95039 + 318 WP_001232701.1 HigA family addiction module antidote protein -
C4E16_RS19570 95036..95146 + 111 WP_134814058.1 DUF3265 domain-containing protein -
C4E16_RS14915 95323..95448 + 126 WP_001944767.1 DUF645 family protein -
C4E16_RS19440 95464..95502 + 39 WP_106019119.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 31043..136234 105191
inside Integron - - 36123..135858 99735


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T95381 WP_001180243.1 NZ_CP026648:c90666-90349 [Vibrio cholerae O1 biovar El Tor]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T95381 NZ_CP026648:c90666-90349 [Vibrio cholerae O1 biovar El Tor]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT95381 WP_000557292.1 NZ_CP026648:c90927-90685 [Vibrio cholerae O1 biovar El Tor]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT95381 NZ_CP026648:c90927-90685 [Vibrio cholerae O1 biovar El Tor]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References